Synapses Flashcards
1
Q
Describe a typical synapse (nts movement)
A
- pre-synaptic neuron is depolarised
- voltage-gated ca2+ channels open
- vesicles fuse with membrane
- nts released into synaptic cleft
- nts bind to receptors on post-synaptic neuron
- reuptake of remaining nts in synapse
2
Q
What are the 2 types of receptors?
A
- ionotropic: ligand-gated ion channels
- metabotropic: G protein coupled
3
Q
What are the cholinergic receptors?
A
- nicotinic ACh receptors (nAChRs): ionotropic
- muscarinic ACh receptors (mAChRs): metabotropic
4
Q
What are cholinergic receptors?
A
- receptors activated by nt acetylcholine, ACh binding
5
Q
What are the adrenergic receptors?
A
- alpha 1 and 2
- beta 1, 2 and 3
(all adrenoreceptors are metabotropic)
6
Q
What are adrenergic receptors?
A
- receptors activated by catecholamines binding
- catecholamines: adrenaline/epinephrine, noradrenaline/norepinephrine, dopamine
7
Q
Outline the human nervous system
A
- central nervous system | CNS
- peripheral nervous system | PNS
8
Q
Outline the CNS
A
- brain
- spinal cord
9
Q
Outline the PNS
A
- somatic nervous system
- autonomous nervous system
10
Q
Outline the autonomous nervous system
A
- sympathetic ns: fight/flight
- parasympathetic ns: rest+digest
- enteric ns: (tbc)
11
Q
Which type of receptors are used in the autonomous ns?
A
- sympathetic ns = adrenergic
- parasympathetic ns = cholinergic
