Sympatholytics

Question 1

Function

Answer 1

Prevent normal physiologic release of norepinephrine from post ganglionic sympathetic neurons

Question 2

Effects

Answer 2

Decrease of blood pressure due to inhibition of influence of sympathetic nervous system on heart and vessels

Question 3

Application of reserpine , mechanism

Answer 3

Arterial hypertension

Mechanism: blocks transport of norepinephrine to vesicles, causing its degradation by MAO and gradual depletion

Question 4

Side effects of reserpine

Answer 4

• bronchial constriction

- hypotension

Question 5

Application and mechanism of guanethidine

Answer 5

Severe arterial hypertension resistant to other drugs
Mechanism : concentrated in vesicles, replacing norepinephrine. Hence, causes gradual depletion of norepinephrine and also inhibits release of norepinephrine to synaptic cleft

Question 6

Side effects of guanethidine

Answer 6

• Orthostatic hypotension

- Diarrhea

Question 7

Application and mechanism of metyrosine

Answer 7

Pheochromocytoma

Mechanism: inhibits synthesis of norepinephrine.

Question 8

Side effects of metyrosine

Answer 8

• sedation
• depression
• disorientation
• diarrhea