Beta Adrenoceptor Blockers Flashcards
1
Q
Non selective beta adrenoceptor blockers
A
- propranolol
- timolol
- pindolol
2
Q
Selective beta 1 adrenoceptor blockers
A
- Metoprolol
- Atenolol
- Bisoprolol
- Esmolol
- Acebutolol
- Nebivolol
3
Q
Effects of blockade of beta 1 adrenoceptors
A
- decrease HR,contractility,automaticity
- decrease renin production leading to decrease in peptide angiotensin II due to decrease in cardiac output results in decreased blood pressure
4
Q
Effects of blockade of beta 2 adrenoceptors
A
- inhibition of glycogenolysis
- bronchial consitriction
- decrease of perpheral blood flow due to vascular constriction to skeletal muscles
- decrease tremors
- decrease intraocular pressure due to decreased intraocular fluid (used as eye drops in glaucoma)
5
Q
Application of beta adrenergic antagonists
A
- Arterial hypertension
- Ischemic heart disease (angina pectoris)
- Myocardial infarction
- Cardiac arrhythmia
- congestive heart failure
- glaucoma
- hyperthyroidism
- Migraine attacks
6
Q
Application of nebivolol
A
Arterial hypertension (endothelial NO vasodilator action)
7
Q
Application of propranolol
A
- inhibits transformation of throxine to more potent T3 hormone
- decrease incidence of migraine attacks
8
Q
Application of timolol
A
- glaucoma
- migraine attacks
9
Q
Advantages of metoprolol and bisoprolol
A
Lower possibility of side effects mediated by block of beta 2 adrenoceptors (bronchial constriction,disorders of blood flow, hypoglycemia)
10
Q
Application of pindolol and acebutolol
A
- beta blockers w intrinsic sympathomimetic activity ( partial agonists of beta adrenoceptors)
- less prominent influence on hear and cardiac output
11
Q
Adverse effects of beta adrenergic antagonists
A
- bradyarrhythmia
- atrioventricular block
-bronchial constriction
Impairment of blood flow in extremities ( cold extremities, claudation) - increased hypoglycemic episodes
