sympathetic receptors (alpha and beta)

Question 1

alpha 1:

Answer 1

stimulation leads to vascular smooth mm contraction–>
increased peripheral resistance
increased BP
mydriasis
increased bladder mm sphincter contraction

Question 2

alpha 2:

Answer 2

on beta cells of the pancreas, smooth mm

on presynaptic nerve inhibits NE release (negative feedback–NE binds alpha 2 causing decreased release of NE)

Question 3

Beta 1:

Answer 3

on heart (1 beta = 1 heart)
stimulation causes: tachycardia, increased lipolysis, increased myocardial contractility, increased renin release

Question 4

Beta 2:

Answer 4

on lungs (2 beta= 2 lungs)
stimulation causes: vasodilation, bronchodilation, increased lipolysis, increased insulin release, increased uterine tone, increased HR d/t decreased BP

Question 5

Which receptors are Gi receptors?

Answer 5

MAD 2’s

M2, alpha 2, D2

Question 6

Which receptors are Gq receptors?

Answer 6

QC’s HAVe 1 M&M

H1, alpha 1, V1, M1 and M3

Question 7

Which receptors are Gs receptors?

Answer 7

Beta 1 and 2, V2, D1, H2

Question 8

How does Gs GPCR work?

Answer 8

Activates adenylyl cyclase–>increased cAMP –>PKA

Question 9

How do Gq work?

Answer 9

Activates PLC–> breaks PIP2 into IP3 and DAG
IP3–> increases intracellular Ca2+
DAG–>activates PKC