Major Side Effects:

Question 1

Flushing:

Answer 1

vancomycin, niacin, adenosine, dihydropyridine CCB

Question 2

Coronary vasospasm

Answer 2

cocaine, amphetamines, triptans, ergotamine

Question 3

Dilated cardiomyopathies

Answer 3

doxorubicin, daunorubicin

Question 4

Torsades de pointes

Answer 4

Class III antiarrythmics (K+ channel blockers), Class IA antiarrythmics (Na channel blockers), macrolides, haloperidol, chloroquine, protease inhibitors

Question 5

Thrombocytopenia

Answer 5

heparin, cimetidine

Question 6

agranulocytosis

Answer 6

3 C’s : clozapine, carbamazepine, colchicine
Antithyroids: propylthiouracil, methimazole
Dapsone

Question 7

aplastic anemia

Answer 7

Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

Question 8

Gray baby syndrome

Answer 8

chloramphenicol

Question 9

Hemolysis in G6PD deficiency:

Answer 9

isoniazid, sulfonamides, primaquine, ASA (high dose), Ibuprofen, nitrofurantoin, dapsone, fava beans, naphthalene

Question 10

Thrombosis

Answer 10

OCPs

Question 11

Pulmonary fibrosis

Answer 11

bleomysin, busulfan, amiodarone

Question 12

Cough

Answer 12

ACE inhibitors

Question 13

Pseudomembranous colitis

Answer 13

Clindamycin, amoxicillin/ampicillin

Question 14

Hepatic necrosis

Answer 14

Halothane, Acetaminophen, valproic acid, Amanita phalloides (bug)

Question 15

Hepatitis

Answer 15

Isoniazid

Question 16

Tertiary adrenal insufficiency

Answer 16

glucocorticoid withdrawal

Question 17

gynecomastia

Answer 17

STACKED:
Spironolactone
THC (marijuana)
Alcohol (chronic)
Cimetidine
Ketoconazole
Estrogens
Digoxin

Question 18

Hot flashes

Answer 18

tamoxifen, clomiphene (SERMs)

Question 19

hypothyroidism

Answer 19

litium, sulfonamides, amiodarone

Question 20

Gout

Answer 20

diuretics (loop and thiazides), niacin, cyclosporine, pyrazinamide

Question 21

gingival hyperplasia

Answer 21

phenytoin, verapamil

Question 22

osteoporosis

Answer 22

corticosteroids, heparin

Question 23

photosensitivity

Answer 23

SAT for a photo:

sulfonamides, amiodarone, tetracyclines

Question 24

Stevens-Johnson Syndrome:

Answer 24

CLAPPPERS
Carbamazepine
Lamotrigine
Allopurinol
Phenytoin
Phenobarbital
Penicillin
Ethosuximide
RASH
Sulfa drugs

Question 25

Drug Induced Lupus

Answer 25

SHIPP
Sulfonamides
Hydralazine
Isoniazid
Phenytoin
Procainamide

Question 26

Tendinitis/Cartilage damage

Answer 26

Fluoroquinolones (hurt the bones)

Question 27

Interstitial nephritis

Answer 27

NSAIDs, furosemide, antibx

Question 28

diabetes insipidis

Answer 28

lithium, demeclocycline

Question 29

Fanconi Syndrome

Answer 29

Expired tetracycline

Question 30

Hemorrhagic cystitis

Answer 30

cyclophosphamide, Ifosfamide

Question 31

Parkinson-like syndrome

Answer 31

metaclopramide, antipsychotics, reserpine

Question 32

Cinchonism

Answer 32

quinidine, quinine

Question 33

Seizures

Answer 33

buproprion, imipenem/cilastatin, isoniazid, tramadol, metoclopramide, benzodiazepine/ETOH withdrawal

Question 34

Tardive dyskinesia

Answer 34

antipsychotics, metoclopramide

Question 35

Disulfiram-like reactions

Answer 35

metronidazole, certain cephalosporins, procarbazine, first gen. sulfonylureas, disulfiram

Question 36

Nephrotoxicity and neurotoxicity

Answer 36

aminoglycosides, cisplatin, polymixins

Question 37

nephrotoxicity and ototoxicity

Answer 37

aminoglycosides, vancomycin, loop diruetics, cisplatin

Question 38

anticholinergic effects

Answer 38

atropine, TCAs, H1 blockers, low-potency neuroleptics