Sympathetic, parasympathetic, dopamine, histamine and ADH receptors

Question 1

Mnemonic to remember Types of GPCRs for the major adrenergic, cholindergic, dopminergic, histamine and vasopressin receptors

Answer 1

qiss and qiq till your siq of having sqs

Question 2

Alpha 1 Receptor - G protein class, Major function

Answer 2

Gq - INCREASED 1) vascular muscle contractions 2) pupillary dilator muscle contraction (mydriasis) 3) intestinal and bladder sphincter muscle contraction

Question 3

Alpha 2 receptor

Answer 3

Gi - DECREASED 1) sympathetic outflow 2) insulin release 3) lipolysis INCREASED platelet aggregation

Question 4

Beta 1 receptor

Answer 4

Gs - INCREASED 1) heart rate 2) contractility 3) lipolysis 4) renin release

Question 5

Beta 2 receptor

Answer 5

Gs - Vasodilation, bronchodilation, ciliary muscle relaxation (i.e., less accommodation), INCREASED 1) heart rate 2) contractility 3) insulin release 4) aq humor production. DECREASED uterine tone (tocolysis)

Question 6

M1 receptor

Answer 6

Gq - CNS, enteric nervous system

Question 7

M2 receptor

Answer 7

Gi - DECREASED heart rate and contractility of atria

Question 8

M3 receptor

Answer 8

Gq - INCREASED 1) exocrine gland secretions (lacrimal, salviary, gastic acid) 2) bladder contraction 3) bronchoconstriction 4) pupillary sphincter muscle contraction (miosis) 5) ciliary muscle contraction (accommodation)

Question 9

D1 receptor

Answer 9

Gs - Renal vasculature smooth muscle relaxation

Question 10

D2 receptor

Answer 10

Gi - Modulates transmitter release, especially in braine

Question 11

H1 receptor

Answer 11

Gq - contraction of bronchioles, pruritis, pain, INCREASED 1) nasal and bronchial mucus production 2) vascular permeability

Question 12

H2 receptor

Answer 12

Gs - Increased gastric acid secretion

Question 13

V1 receptor

Answer 13

Gq - vascular smooth muscle contraction

Question 14

V2 receptor

Answer 14

Gs - Increase H2O permeability and reabsorption in collecting tubules

Question 15

Which GCPRs use the Gq pathway?

Answer 15

HAVe 1 M&M. H1, alpha1, V1, M1 and M3.
Gq => PLC => PIP2 converted to DAG and IP3. DAG => protein kinase C, IP3 increases intracellular Ca2+ concentration which leads to smooth muscle contraction

Question 16

Which GPCRs use the Gs pathway

Answer 16

beta1, beta2, D1, H2, V2. activate AC => convert ATP to cAMP => PKA => increases intracellular Ca2+ concentration in heart leading to contractility and also INHIBITS myosin light chain kinase

Question 17

Which GPCRs use the Gi pathyway

Answer 17

MAD2s = M2, alpha2, D2. inhibit AC