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CPPS 304 > Sympathetic Nervous System > Flashcards

Sympathetic Nervous System Flashcards

1
Q

What compounds can mimick sympathetic effects?

A
  • Andregenic Receptor Agonists (Direct Acting)
  • Norephinephrine Uptake Blockers (indirect Acting)
  • Monoamine Oxidase and COMT inhibitors (Indirect)
  • NE releasing agents (indirect)

MO and COMT inhibitors delay breakdown of NE, E, Dopamine

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2
Q

What compounds can block sympathetic effects?

A

Andregenic Receptor Antagonists

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3
Q

Explain NE termination at the synapse.

A
NE is taken back to Presynaptic Nerve Terminal Alpha 1 receptor is Andregenic Alpha 2 is Presynaptic Negatvie Feedback (Anti-andregenic)
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4
Q

What type of receptors can Epinephrine Activate?

A

Equal Activation at all subtypes - Alpha and Beta.

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5
Q

What type of receptors can NE activate?

A

Can activate Alpha and Beta 1 receptors. Little effect on B2. NE not a good bronchodilater.

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6
Q

What receptors can Dopamine Activate?

A

Activates Cardiac B1 receptors.

Can activate kidney dopamine receptors causing increase in blood flow

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7
Q

What are the main sympathetic receptors in the heart and what are the effects produces from stimulation and blocking of these receptors?

A

B1 - 80 Percent
B2 - 20 Percent

Stimulation of both produce same effects

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8
Q

What is a therapeutic use of Beta and Selective Beta 1 Agonists on the heart?

A
  • To treat cardiogenic shock and stimulate contractility.
  • Used for Allergic Reactions: Epiephrine (Increase contracility, constricts and dilates vessels to maintain BP, bronchodilation, removal of mediators from mast cells.
  • To treat Resistant Heart Failure - B1 Agonist (Not first choice)

Adverse Effect: Arrythmias (Overstimulation)

Should Not Use: Patients with cardiac conditions.

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9
Q

What is the therapeutic use of Beta and Beta 1 blockers on the heart?

A

Most Widely used drugs for cardiovascular conditons.

Used to treat hypertension, cardiac arrythmias, congestive heart failure etc.** Decrease Atrioventricular Conduction, Decrease Contractility. **

Adverse Effects: Can Cause Bradycardia or Heart Block

Should Not Use: Patients who have Conduction Defects involving the AV Node

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10
Q

What are the sympathetic receptors for Blood vessels and what is the effect of the stimulation and blocking of these receptors?

A

A1 however some vessels(skeletal muscle vessels) have beta 2 receptors which produce vasodilation.

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11
Q

What are the therapeutic uses for alpha 1 agonists for blood vessels?

A

Used to treat hypotension. Produce local vaoconstriction. Treat Nasal Decongestion (Constricts Mucosal Vessels)

Adverse Effects: Reflex Bradycardia (triggers baro-reflex)

Should Not Use: With Patients with Arrythmias of Vascular Conditions.

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12
Q

What are the therapeutic uses of Alpha 1 blockers for blood vessels?

A

**Used to treat hypertension. **

Adverse Effect: Reflex Tachycardia (increased blood pressure triggers the Baro - reflex) - Due to Vasodilation of B2 vessels.

Remember: Skeletal muscle, pulmonary, abdominal viscera, renal and coronary vessels have β2
receptors which cause VASODILATION and decrease vessel resistance. E.g. epinephrine will
dilate these vessels, NE will not (little B2 activity)

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13
Q

What is the therapeutic use of Alpha 2 agonist in blood vessels?

A

Alpha 2 is presynaptic - prevents release of NE from nerve terminal through negative feeback inhibition.

**Used to treat hypertension **- A2 agonist has anti sympathetic effect.

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14
Q

What is the therapeutic use of Beta blockers in blood vessels?

A

**Prevents vasodilation of blood vessels where these receptors are present.
***
Non selective beta blockers used for glaucoma because they reduce secretion of ciliary body.

No such thing as selective Beta 2 blocker yet

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15
Q

What is the dominant tone of the kidney?

A

Sympathetic

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16
Q

What is the sympathetic receptors in the kdiney and what are the effects from stimulation and blocking of these receptors.

A

B1

17
Q

What are the therapeutic uses of Beta blockers and B1 blockers on the Kidney?

A

Decrease renin-angiotensin aldosterone activity redcuing blood pressure.

18
Q

What are the sympathetic receptors in the Urinary Bladder and what are the effects from the stimulation and blocking of these receptors?

A

B3 (Not significant), A1 (Internal Sphincter)

19
Q

What are the therapeutic uses of Alpha 1 blockers for the Urinary bladder?

A

To treat difficulty emptying the bladder of benign prostatic hyperplasia.

Almost always treatment of first choice

20
Q

What are the sympathetic receptors of the GI Tract and what is the effect of stimulation and blocking of these receptors?

A

A1, A2, B1, B2

Very Little sympathetic effect compared to parasympathetic.
21
Q

What are the sympathetic receptors of salivary glands and what are the effects from stimulation and blocking of these receptors?

A

A1

Sympathetic Effect is very mild.
22
Q

What is the dominant tone of the Liver?

A

Sympathetic

23
Q

What are the sympathetic receptors in the liver and what effect to they have from the stimulation and blocking of these receptors.

A

B2

**Stimulation of B2 by epinephrine causes Glycogenolysis and gluconeogenesis. **

24
Q

What is the clinical relevance of Non selective B blockers in the liver?

A

Type 1 diabetic patients on insulin ar eprone to develop hypoglycemia and coma as a serious side effect of insulin. Sympathetic system is activated during hypoglycemia and helps release glucose to correct the coma.

Non Selective Beta Blockers block this.

Should not give non selective B blockers to Type 1 Diabetics.

25
Q

What are the sympathetic receptors in tracheal and bronchial smooth muscle and what are the affects from the stimulation and blocking of these receptors?

A

B2

26
Q

What are the therapeutic uses of B2 agonists on bronchial smooth muscle and glands?

A

Used to treat asthma and COPD following anaphylactic reaction. First choice of treatment however desensitization upon frequent repeated use.

Adverse Effect: Can cause tachycardia and cardiac arrythmias.

27
Q

What are the therapeutic uses of Non selective Beta blockers on bronchial smooth muscle?

A

No selective B2 blockers.
No Therapeutic Uses

Adverse Effects: In people with asthma or COPD - can cause severe bronchoconstriction.

Should Not Use:Non Selective B Blockers should not be given to people with asthma and COPD

28
Q

What is the dominant tone in the uterus?

A

Sympathetic Innervation

29
Q

What are the sympathetic receptors in the uterus and what happens when receptor is stimulated?

A

B2

Relaxation of Uterine Smooth Muscle

30
Q

What are the therapeutic uses of B2 agonists in the Uterus.

A

Use SABA’s - Short Acting Beta 2 Agonists to prevent premature labour.

Should Not Use: Oral B2 Agonists - Great risk of cardiovascular adverse effects in the mother and baby.

Has to be given parenteral SABAS for a a max of 48 hr.

31
Q

Explain the sympathetic affect in the eyes.

A
As well as the B2 effect for Glaucoma.
32
Q

What are some other uses for andregenic drugs?

A

CNS stimulants used to treat ADHD and narcolepsy and as an anorectic to redice appetite and treat obesity

Phophylactic to prevent migraine headache.

CPPS 304 (11 decks)

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