Switching On And Maintaining A Fuel Supply Flashcards
0
Q
Which hormones are counter regulatory to insulin?
A
Glucagon
Adrenaline
Cortisol
Growth hormone
1
Q
What are the actions of insulin?
A
Increase glucose uptake in muscle, fat or liver Decrease lipolysis Decrease amine acid release from muscle Decrease gluconeogenesis in liver Decrease ketogenesis in liver
2
Q
What are the substrates of gluconeogenesis?
A
Lactate
Pyruvate
Alanine (from muscle stores)
Glycerol (from fat stores)
3
Q
What is the substrate for ketogenesis?
A
Fatty acids
4
Q
What does the beta oxidation of fatty acids inside the mitochondrion produce?
A
Acetyl coA
5
Q
What causes interuterine growth restriction?
A
High demands Low stores Immature gluconeogenic pathways Starved in utero Didn't get a chance to lay down stores
6
Q
What causes neonatal hypoglycaemia?
A
Glycogen storage disease (usually type 1)
MCAD (medium chain acetyl coA dehydrogenase deficiency)
7
Q
What causes glycogen storage disease (type 1)?
A
Deficiency of glucose 6 phosphatase
Hypoglycaemia and lactic acidosis in newborn
Hepatomegaly in older child
