Sweatman Pulm. Overview Flashcards
major med types for Chronic Obstructive Lung Disease
BRONCHODILATORS*
Beta Agonists
&
Anticholinergic agents
other drug classes for pulm tx
inhaled glucocorticoids inhaled antibiotics airway secretion modifying agents inhaled vasodilators aerosolized opiates
Advantages of Inhaltion route
> Far more permeable to small molecules than any other portal
low efflux/metabolism–> clean delivery
no undesired metabolites as in hepatic
fastest delivery other than IV (invasives)
physical barrier to inhalation delivery
epithelium of airway
Thick in trachea thin in alveoli
adverse effect of inhaled steroids
- ->opportunistic infections in the mouth when the steroid diminishes the immune system locally when deposited in the oral cavity
- ->can decay tooth enamel integrity from the acid
what determines the rate of drug absorptions
- Lipiphillicity
- charge
- size (MW)
Small hydrophillic compounds diffusion
100-1000D–> ionization dominates
Above 100-1000 D
MW factors in along with lipiphillicty and charge
ideal molecule for absorption
small, lipid, uncharged…moves well, with little interaction with the native proteins and lipid means it can move transcellularly
Inflamamtour lung conditions
Asthma COPD Allergic Rhinitis Restrictive Lung diseases PAH
INfectious Lung DIseases
Tuberculosis
Pneumonia (Viral, Fungal, Viral)
neoplastic disease of the lung
NON-small cells lung cnacer
Small cell lung cancer (carcinoid-tumorlettes) NEUROENDOCRINE
tx for Upper Resp Tract COditions
mucolytics
vasoconstrcitors
Drugs acting the CNS to combat cough
antihistamines
tx’s for lung (lower airway disease)
asthma and COPD (obstructive)
Restrictive (fibrosis)
Pulmonary Artery Hypertension
Whats unique about mucolytics
never enter the body, simply break up the muchous so the elevator can move it better
