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Pulmonology > Pathology: Lung Cancer genetic/immunostain Markers > Flashcards

Pathology: Lung Cancer genetic/immunostain Markers Flashcards

1
Q

targetted therapy for EGFR

A

erlotinib

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2
Q

targeted therapy for ALK

A

crizotinib

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3
Q

egfr-dependent pathway is found in

A

non-smokers

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4
Q

KRAS dependent pathway found in

A

smokers

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5
Q

name the five types of adenocarcinoma

A 
acinar--> most common
papillary
micropapillary bad prognisis
lepidic (AIS--> good )
solid (bad prognosis)
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6
Q

cancer most likely to cavitate

A

Squamous cell carcinoma

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7
Q

profile of adeno carcinoma

A

CK 7+
Napsin A+
TTFi +

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8
Q

profile of squamous cell carcinoma

A

CD 5/6 +
p40+
p63+

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9
Q

contraindicated in squamous cell carcinoma

A

bevacizumab

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10
Q

most likely cancer to cause paraneoplastic syndrom

A

small cell

  1. cushing’s
  2. SIADH
  3. eaton-lambert syndrome
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11
Q

most likley to cause hypercalcemia

A

squamous cell

PTHRp

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12
Q

syndrome seen with carcinoid tumors

A

carcinoid syndrome

  1. flushing
  2. diarrhea
  3. cyanosis
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13
Q

pembertons sign seen with

A

small cell

facial flushingand distended head/nek veins upon raising both arms

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14
Q

cancer most associated with smoking

A

small cell carcinoma

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15
Q

medastinal lympahdenopathy out of proportion to lung lesion

A

SMall cell

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16
Q

cavitation more likley to be

A

squamous cell

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17
Q

non-smoker most likley to be

A

adenocarcinoma

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18
Q

“lepidic” growth pattern

A

adenocacinoma in situ
“formerly bronchioloalveolar carcinoma”
–> not invasive and great prognosis

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19
Q

two types of adenocarcinoma in situ of lung

A
  1. mucinoud and 2. non mucinous
20
Q

NON-Mucinous AIS prominent in

A

smokers

21
Q

mucinous AIS promenent in

A

smokers

22
Q

stage I and 2

A

small enough to be removed

23
Q

stage 3

A

involvement of structure unable to be surgically removed wihtout distant mets

24
Q

stage 4

A

structures unable to be surgically removed and with distant mets

25
Q

non-mucinous more likley to arise from ____ cells

A

terminal respiratory unit cells CLARA cells and TIIP’s

26
Q

radiographic sign for non-mucinous

A

groud glass–> Single Nodule

27
Q

better prognosis AIS subtype

A

NON-mucinous–> more often Sxlly resectable

28
Q

Non-mucinous profile

A

EGFR +
TTFI+
CK 20-
TTFI -

29
Q

Mucinous more promient in

A

non-smokers

30
Q

radiographic signs of

A

pneumonia pattern–> multifocal nodules

31
Q

AIS with worse prognosis

A

Mucinous sub type–> usually not surgically resctable

32
Q

mucinous profile

A

CK 20+
KRAS +
TTFI -
EGFR -

33
Q

chromogrammin + types

A

Small cell carcinoma

Carcinoid

34
Q

centrally located lesaions that cause cough and or hemoptysis

A

SCLC

Squamous cell

35
Q

most common to cause hemoptysis

A

Squamous cell–> because most likely to cavittate

36
Q

brain mets wiht unidentified source

A
  1. Lung– unidentified lesion

2. breast second most common

37
Q

tx of small cell lung carcinoma

A

never surgically resectable–> go directly to cytotoxic chemotherapy

38
Q

markers for primary lung tumor

A

CK 7+
TTF1 +
CK 20-
cdx2-

39
Q

Colon primary markers

A

ck 20+

cdx2+

40
Q

breast primary markers

A

ck7+ only

41
Q

kidneys markers

A

negative for all four

ck7 cdx2 ttf1, ck20

42
Q

mesothelioma marker

A

p67

43
Q

smoking and asbestos exposure increase risk of ____ x 5 fold

A

bronchogenic lung cancer only

44
Q

pt’s with asbestos exposure more likely to get_____

A

lung cancer over mesothelioma

45
Q

profile of mesothelioma

A

WT1
CK 5/6
d2-40
calretin

46
Q

genetic mishap in mesothelioma

A

homozygous deltion of CDKn2A/INK4a

Pulmonology (10 decks)

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