Suspension Theory Flashcards

1
Q

Suspension

A

A suspension is a dispersion of solid particles of a material in a liquid medium + is cloudy

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2
Q

The particles in a suspension generally have a higher density than the

A

Liquid medium + will settle over time, giving rise to dose homogeneity issues

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3
Q

Surface

A

A surface is an interface between 2 phases, where one phase is a solid

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4
Q

Properties of a surface

A

Surfaces behave differently to the bulk material
Nearly everything happens at the surfaces - even though they are a small % of the whole
All interfacial phenomena apply

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5
Q

Surface science

A

The study of surface phenomena
=> Properties of surfaces of bulk material
=> Interactions with fluids
=> Interactions with other surfaces

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6
Q

Suspension

A

A “suspension” is a dispersion of a solid material (the dispersed phase) in a fluid ( the continuous phase)

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7
Q

Colloid

A

A suspension where the particles are in the size range up to approx. 1 micro metre
=> Some very large molecules (eg DNA) behave like colloids

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8
Q

Colloid science

A

The study of colloids
=> Interactions:
Particle/ particle and particle / medium

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9
Q

Suspension doseability is vital

A

Each dose must contain the correct amount of drug
Each dose must be exactly the same
Particles should not interact
Particles should not sediment or cake

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10
Q

Particle behaviour in suspensions. Facts to consider

A
Charge on the particle surface
Electrical double layer
DVLO theory 
Sedimentation kinetics 
Surface wettability 
Effect of added materials
Physicochemical nature of solid material, eg solubility
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