Surgery - Urology Flashcards

1
Q

Testicular torsion

  • Cause
  • Typical presentation
A

Cause:
Often triggered by activity, cause twisting of spermatic cord
Bell-Clapper deformity: fixation between testicle and tunica vaginalis absent, testicles lie horizontally, prone to torsion

acute rapid onset of unilateral testicular pain
abdominal pain and vomiting
swollen testicles
Retraction of testicles 
Absent cremasteric reflex
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2
Q

Management of testicular torsion

Is imaging necessary?

A

UROLOGICAL EMERGENCY

Nil by mouth, in preparation for surgery
Analgesia as required
Surgical exploration of the scrotum**
Orchiopexy (correcting the position of the testicles and fixing them in place)
Orchidectomy (removing the testicle) if the surgery is delayed or there is necrosis

scrotal ultrasound can confirm the diagnosis, but delay surgery is contraindicated

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3
Q

Characteristic imaging sign of testicular torsion

A

Ultrasound can show the whirlpool sign, a spiral appearance to the spermatic cord and blood vessels.

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4
Q

Causes of epididymo-orchitis

A
Causes
Escherichia coli (E. coli)
Chlamydia trachomatis
Neisseria gonorrhoea
Mumps

(Think of mumps in patients with parotid gland swelling and orchitis. Mumps can also cause pancreatitis)

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5
Q

Typical presentation of epididymo-orchitis

A

over minutes to hours, with unilateral:

Testicular pain
Dragging or heavy sensation
Swelling 
Tenderness on palpation
Urethral discharge (should make you think of chlamydia or gonorrhoea)

Systemic symptoms such as fever and potentially sepsis

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6
Q

Investigations for epidydymo-orchitis

A

Urine microscopy, culture and sensitivity (MC&S)

Chlamydia and gonorrhoea NAAT testing on a first pass urine

Charcoal swab of purulent urethral discharge for gonorrhoea culture and sensitivities

Saliva swap for PCR testing for mumps
Serum antibodies for mumps

Ultrasound may be used to assess for torsion or tumours

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7
Q

Management of epidydymo-orchitis

A

Analgesia
Supportive underwear
Reduce physical activity
Abstain from intercourse

Antiobiotics:
Ofloxacin*/Levofloxacin / ciprofloxacin
Doxycycline
Co-amoxiclav

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8
Q

Complications of epidydymo-orchitis

A
Chronic pain
Chronic epididymitis
Testicular atrophy
Sub-fertility or infertility
Scrotal abscess
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9
Q

Prostatitis:

- Typical presentation

A

Pelvic pain, which may affect the perineum, testicles, scrotum, penis, rectum, groin, lower back or suprapubic area

Lower urinary tract symptoms, such as dysuria, hesitancy, frequency and retention

Sexual dysfunction, such as erectile dysfunction, pain on ejaculation and haematospermia (blood in the semen)

Pain with bowel movements

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10
Q

Investigations for prostatitis

A

Urine dipstick testing can confirm evidence of infection.

Urine microscopy, culture and sensitivities (MC&S) can identify the causative organism and the antibiotic sensitivities.

Chlamydia and gonorrhoea NAAT testing on a first pass urine, if sexually transmitted infection is considered.

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11
Q

Management of acute prostatitis

A

Hospital admission for systemically unwell or septic patients (for bloods, blood cultures and IV antibiotics)

Oral antibiotics, typically for 2-4 weeks (e.g., ciprofloxacin, ofloxacin or trimethoprim)

Analgesia (paracetamol or NSAIDs)

Laxatives for pain during bowel movements

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12
Q

Management of chronic prostatitis

A

Alpha-blockers (e.g., tamsulosin) relax smooth muscle, with rapid improvement in symptoms

Analgesia (paracetamol or NSAIDs)

Psychological treatment, where indicated (e.g., cognitive behavioural therapy and / or antidepressants)

Antibiotics if less than 6 months of symptoms or a history of infection (e.g., trimethoprim or doxycycline for 4-6 weeks)

Laxatives for pain during bowel movements

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13
Q

Complications of chronic prostatitis

A

Sepsis
Prostate abscess (may be felt as a fluctuant mass and requires surgical drainage)
Acute urinary retention

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14
Q

List lower urinary tract symptoms (LUTS)

A

Hesitancy – difficult starting and maintaining the flow of urine

Urgency – a sudden pressing urge to pass urine
Frequency – needing to pass urine often, usually with small amounts
Intermittency – flow that starts, stops and varies in rate
Straining to pass urine

Weak flow
Terminal dribbling – dribbling after finishing urination
Incomplete emptying – not being able to fully empty the bladder, with chronic retention

Nocturia – having to wake to pass urine multiple times at night

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15
Q

5 assessments for LUTS

A

Digital rectal examination (prostate exam) to assess the size, shape and characteristics of the prostate

Abdominal examination to assess for a palpable bladder and other abnormalities

Urinary frequency volume chart, recording 3 days of fluid intake and output

Urine dipstick to assess for infection, haematuria (e.g., due to bladder cancer) and other pathology

Prostate-specific antigen (PSA) for prostate cancer, depending on the patient preference

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16
Q

Causes of raised PSA

A
Prostate cancer
Benign prostatic hyperplasia
Prostatitis
Urinary tract infections
Vigorous exercise (notably cycling)
Recent ejaculation or prostate stimulation
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17
Q

Describe cancerous prostate on palpation

A

cancerous prostate may feel firm/hard, asymmetrical, craggy or irregular, with loss of the central sulcus

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18
Q

Medical treatment of BPH

A

Alpha-blockers (e.g., tamsulosin) relax smooth muscle, with rapid improvement in symptoms

5-alpha reductase inhibitors (e.g., finasteride) gradually reduce the size of the prostate

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19
Q

Surgical treatment for BPH

A

Transurethral resection of the prostate (TURP) **

Transurethral electrovaporisation of the prostate (TEVAP/TUVP)

Holmium laser enucleation of the prostate (HoLEP)
Open prostatectomy via an abdominal or perineal incision

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20
Q

5 types of urinary catheters

A

Intermittent catheters – simple catheters used to drain urine, then immediately removed

Foley catheter (two-way catheter) – the “standard” catheter with an inflatable balloon to hold it in place

Coudé tip catheter – has a curved tip to help navigate it past an obstruction during insertion

Three-way catheter – has three tubes used for inflating the balloon, injecting irrigation and drainage

Suprapubic catheters

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21
Q

Indications for urinary catheter insertion

A

Urinary retention due to a lower urinary tract obstruction (e.g., enlarged prostate)

Neurogenic bladder (e.g., intermittent self-catheterisation in multiple sclerosis)

Surgery (during and after)

Output monitoring in acutely unwell patients (e.g., sepsis or intensive care)

Bladder irrigation (e.g., to wash out blood clots in the bladder)

Delivery of medications (e.g., chemotherapy to treat bladder cancer)

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22
Q

Obstructive uropathy

- Upper urinary tract causes

A

Kidney stones
Tumours pressing on the ureters
Ureter strictures (due to scar tissue narrowing the tube)
Retroperitoneal fibrosis (the development of scar tissue in the retroperitoneal space)
Bladder cancer (blocking the ureteral openings to the bladder)
Ureterocele (ballooning of the most distal portion of the ureter – this is usually congenital)

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23
Q

Obstructive uropathy

- Lower urinary tract causes

A

Benign prostatic hyperplasia (benign enlarged prostate)
Prostate cancer
Bladder cancer (blocking the neck of the bladder)
Urethral strictures (due to scar tissue)
Neurogenic bladder

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24
Q

Obstructive uropathy

- functional causes

A

Neurogenic bladder:

Multiple sclerosis
Diabetes
Stroke
Parkinson’s disease
Brain or spinal cord injury
Spina bifida
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25
Q

Management of obstructive uropathy

A

Nephrostomy

Urethral/ suprapubic catheter

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26
Q

Complications of obstructive uropathy

A

Pain
Acute kidney injury (post-renal)
Chronic kidney disease
Infection (from bacteria tracking up urinary tract into areas of stagnated urine)
Hydronephrosis (swelling of the renal pelvis and calyces in the kidney)
Urinary retention and bladder distention
Overflow incontinence of urine

27
Q

Treatment of hydronephrosis

A

Percutaneous nephrostomy – inserting a tube through the skin and kidney into the ureter, under radiological guidance

Antegrade ureteric stent – inserting a stent through the kidney into the ureter, under radiological guidance

28
Q

Risk factors of prostate cancer

Symptoms

A
Increasing age
Family history
Black African or Caribbean origin
Tall stature
Anabolic steroids 
Symptoms:
LUTS
Haematuria
Erectile dysfunction 
Symptoms of advanced disease or metastasis (e.g., weight loss, bone pain or cauda equina syndrome)
29
Q

Options for prostate biopsy

A

Transrectal ultrasound-guided biopsy (TRUS)

Transperineal biopsy

30
Q

Histological grading system for prostate cancer

A

Gleason score will be made up of two numbers added together for the total score (for example, 3 + 4 = 7):

The first number is the grade of the most prevalent pattern in the biopsy
The second number is the grade of the second most prevalent pattern in the biopsy

A Gleason score of:
6 is considered low risk
7 is intermediate risk (3 + 4 is lower risk than 4 + 3)
8 or above is deemed to be high risk

31
Q

Treatment options for prostate cancer

A

Surveillance or watchful waiting in early prostate cancer
External beam radiotherapy directed at the prostate
Brachytherapy ( implanting radioactive metal “seeds” into the prostate)
Hormone therapy
Surgery - Radical prostatectomy

32
Q

Hormone therapy options for prostate cancer

A

Androgen-receptor blockers such as bicalutamide

GnRH agonists such as goserelin (Zoladex) or leuprorelin (Prostap)

Bilateral orchidectomy to remove the testicles (rarely used)

33
Q

Ddx of scrotal lump

A
Hydrocele
Varicocele
Epididymal cyst
Testicular cancer
Epididymo-orchitis
Inguinal hernia
Testicular torsion
34
Q

Causes of hydrocele

A

idiopathic, with no apparent cause, or secondary to:

Testicular cancer
Testicular torsion
Epididymo-orchitis
Trauma

35
Q

Causes of varicocele

A

Swollen pampiniform plexus due to:

Obstruction in left testicular vein (e.g. by RCC)
Incompetent valves in testicular vein

36
Q

Complications of varicoceles

A

impaired fertility

testicular atrophy

37
Q

Typical presentation of varicoceles

A

Throbbing/dull pain or discomfort, worse on standing
A dragging sensation
Sub-fertility or infertility

Examination findings are:
A scrotal mass that feels like a “bag of worms”
- More prominent on standing
- Disappears when lying down
Asymmetry in testicular size if the varicocele has affected the growth of the testicle

38
Q

Investigations for varicoceles

A

Ultrasound with Doppler imaging can be used to confirm the diagnosis
Semen analysis if there are concerns about fertility
Hormonal tests (e.g., FSH and testosterone) if there are concerns about function

39
Q

Epididymal cyst

- Presentation

A
Soft, round lump 
Typically at the top of the testicle
Associated with the epididymis
Separate from the testicle
May be able to transilluminate large cysts (appearing separate from the testicle)
40
Q

3 main types of testicular cancers

A

Seminoma
Non-seminomas (mostly teratomas)
Leydig cell tumor (gynaecomastia)

41
Q

Investigations for testicular cancer

A

Scrotal ultrasound

Tumour markers for testicular cancer are:
Alpha-fetoprotein – may be raised in teratomas (not in pure seminomas)
Beta-hCG – may be raised in both teratomas and seminomas

staging CT scan - Royal Marsden Staging system (extent of metastasis)

42
Q

Management of testicular cancer

A

Surgery to remove the affected testicle (radical orchidectomy) with prosthesis

Chemo and radiotherapy

Sperm banking

43
Q

Lower UTI presentation

A
Dysuria (pain, stinging or burning when passing urine)
Suprapubic pain or discomfort
Frequency
Urgency
Incontinence
Haematuria
Cloudy or foul smelling urine
44
Q

Pyelonephritis symptoms

A

Fever
Loin/back pain
Nausea/vomiting
Renal angle tenderness on examination

45
Q

Investigation for UTI

A

Dipstick: nitrites, leukocyte esterase, RBC

MSU for culture and sensitivity testing

46
Q

Typical pathogens causing UTI

A

E.coli***

Klebsiella pneumoniae (gram-negative anaerobic rod)
Enterococcus
Pseudomonas aeruginosa
Staphylococcus saprophyticus

Candida albicans (fungal)

47
Q

Antibiotics for lower UTI

A

Trimethoprim (often associated with high rates of bacterial resistance)
Nitrofurantoin (avoided in patients with an eGFR <45)

Pivmecillinam
Amoxicillin
Cefalexin

48
Q

Interstitial cystitis

  • Presentation
  • Investigation
A

typical presentation is more than 6 weeks of:

  • Suprapubic pain, worse with a full bladder and often relieved by emptying the bladder
  • Frequency of urination
  • Urgency of urination

IX:
- Hunner lesions and granulations (tiny bleeds) seen during cystoscopy
- Urinalysis for urinary tract infections
- Swabs for sexually transmitted infections
- Cystoscopy for bladder cancer
Prostate examination for prostatitis, hypertrophy or cancer

49
Q

Bladder cancer

  • Major risk factors
  • Histological types
  • Presentation
A

Risk factors:

  • Aromatic amines in dye and rubber and cigarettes
  • Schistosomiasis

Histological types:
Transitional cell carcinoma (90%)
Squamous cell carcinoma (5% – higher in areas of schistosomiasis)
Rarer causes are adenocarcinoma (2%), sarcoma and small-cell carcinoma

Painless haematuria

50
Q

Investigation for bladder cancer

A

Cystoscopy under GA or LA

TNM staging with CT

51
Q

Treatment options for bladder cancer

A
Transurethral resection of bladder tumour (TURBT)
Intravesical chemotherapy (chemotherapy given into the bladder through a catheter) 

Intravesical Bacillus Calmette-Guérin (BCG) (BCG vaccine into bladder to stimulate immune attack of cancer)

Radical cystectomy with ileal conduit*** or Ureterosigmoidostomy (ureters connect to sigmoid colon)

52
Q

5 types of kidney stones

A

Calcium oxalate (more common)
Calcium phosphate
Uric acid – these are not visible on x-ray
Struvite – produced by bacteria, therefore, associated with infection
Cystine – associated with cystinuria, an autosomal recessive disease

53
Q

Renal stone presentation

A

Unilateral loin to groin pain that can be excruciating (“worse than childbirth”)
Colicky (fluctuating in severity) as the stone moves and settles

Haematuria
Nausea or vomiting
Reduced urine output
Symptoms of sepsis, if infection is present

54
Q

Investigation for renal stones

A

Urine dipstick for exclusion of haematuria and infection

Blood test: serum calcium

Abdominal X-ray

Non-contrast CT KUB

Ultrasound KUB

55
Q

Cause of calcium renal stones and associated symptoms

A

Calcium supplements
Hyperparathyroidism
Cancer: Myeloma, breast or lung cancer with PTHrP

56
Q

Management of renal stones

A

NSAID: Intramusclular diclofenac
Antiemetics
Antibiotics
Tamsulosin - spontaneous passage

Extracorporeal shock wave lithotripsy (ESWL)
Ureteroscopy and laser lithotripsy
Percutaneous nephrolithotomy (PCNL) under GA

57
Q

Lifestyle modifications for calcium and uric acid renal stones

A

calcium stones – reduce the intake of oxalate-rich foods (e.g., spinach, beetroot, nuts, rhubarb and black tea)

uric acid stones – reduce the intake of purine-rich foods (e.g., kidney, liver, anchovies, sardines and spinach)

Increase oral fluid intake (2.5 – 3 litres per day)

Add fresh lemon juice to water (citric acid binds to urinary calcium reducing the formation of stones)

Avoid carbonated drinks (cola drinks contain phosphoric acid, which promotes calcium oxalate formation)

Reduce dietary salt intake (less than 6g per day)

Maintain a normal calcium intake (low dietary calcium might increase the risk of kidney stones)

58
Q

Risk factors for RCC

A
Smoking
Obesity
Hypertension
End-stage renal failure
Von Hippel-Lindau Disease
Tuberous sclerosis
59
Q

Presentation of RCC

A

classic triad of presentation is haematuria, flank pain and a palpable mass

Non-specific symptoms of cancer (e.g., weight loss, fatigue, anorexia, night sweats)

60
Q

Paraneoplastic syndrome associated with RCC

A

Polycythaemia – due to secretion of unregulated erythropoietin
Hypercalcaemia – due to secretion of a hormone that mimics the action of parathyroid hormone
Hypertension – due to various factors, including increased renin secretion, polycythaemia and physical compression
Stauffer’s syndrome – abnormal liver function tests (raised ALT, AST, ALP and bilirubin) without liver metastasis

61
Q

Surgical options for RCC

A
Partial nephrectomy (removing part of the kidney)
Radical nephrectomy (removing the entire kidney plus the surrounding tissue, lymph nodes and possibly the adrenal gland)
  • Arterial embolisation
  • Percutaneous cryotherapy
  • Radiofrequency ablation
62
Q

Immunosuppressants for kidney transplant

A

life-long immunosuppression to reduce the risk of transplant rejection. The usual regime is:

Tacrolimus
Mycophenolate
Prednisolone

Or Cyclosporine
Sirolimus
Azathioprine

63
Q

Complications of immunosuppressants for kidney transplant

A
  • Immunosuppressants often cause seborrhoeic warts and skin cancers (look for scars from skin cancer removal)
  • Tacrolimus causes a tremor
  • Cyclosporine causes gum hypertrophy
  • Steroids cause features of Cushing’s syndrome
General:
Ischaemic heart disease
Type 2 diabetes (steroids)
Infections 
Non-Hodgkin lymphoma
Skin cancer (particularly squamous cell carcinoma)