Surgery - General Surgery (Abdomen) Flashcards

1
Q

Causes of Generalised abdominal pain

A

Peritonitis
Ruptured abdominal aortic aneurysm
Intestinal obstruction
Ischaemic colitis

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2
Q

Causes of RUQ pain

A

Biliary colic
Acute cholecystitis
Acute cholangitis

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3
Q

Causes of epigastric pain

A

Acute gastritis
Peptic ulcer disease
Pancreatitis
Ruptured abdominal aortic aneurysm

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4
Q

Causes of central abdominal pain

A

Ruptured abdominal aortic aneurysm
Intestinal obstruction
Ischaemic colitis
Early stages of appendicitis

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5
Q

Causes of right iliac fossa pain

A
Acute appendicitis
Ectopic pregnancy
Ruptured ovarian cyst
Ovarian torsion
Meckel’s diverticulitis
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6
Q

Causes of left iliac fossa pain

A

Diverticulitis
Ectopic pregnancy
Ruptured ovarian cyst
Ovarian torsion

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7
Q

Causes of suprapubic pain

A

Lower urinary tract infection
Acute urinary retention
Pelvic inflammatory disease
Prostatitis

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8
Q

Causes of loin to groin pain

A
Renal colic (kidney stones)
Ruptured abdominal aortic aneurysm
Pyelonephritis
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9
Q

Causes of Testicular pain

A

Testicular torsion

Epididymo-orchitis

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10
Q

Causes of peritonitis

A

Spontaneous bacterial peritonitis (ascites, liver disease)

Generalised peritonitis (abdominal organ perforation)

Localised peritonitis (underlying organ inflammation)

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11
Q

Investigations for acute abdomen

A
CBC
Urea and electrolytes 
LFTR
CRP 
Amylase 
INR 
Lactate 
Arterial blood gas 
Blood culture
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12
Q

Imaging for acute abdomen

A

Abdominal X-ray: bowel obstruction
Chest X-ray: air under diaphragm for intra-abdominal perforation/ pneumoperitoneum
Ultrasound: gallstones, biliary duct dilatation and gynaecological pathology
CT abdomen: acute abdomen and determine correct management

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13
Q

Initial management of acute abdomen

A
Nil by mouth 
NG tube 
IV resuscitation 
IV antibiotic coverage 
Analgesia 

Venous thromboembolism risk assessment

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14
Q

Define McBurney’s point

A

area one third of the distance from the anterior superior iliac spine (ASIS) to the umbilicus.

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15
Q

Classical features of appendicitis

A

Loss of appetite (anorexia)
Nausea and vomiting
Rovsing’s sign (palpation of the left iliac fossa causes pain in the RIF)
Guarding on abdominal palpation
Peritonitis: Rebound tenderness in the RIF, Percussion tenderness

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16
Q

Ddx of acute appendicitis

A

Ovarian Cysts - pelvic and iliac fossa pain
Meckel’s Diverticulum - malformation of the distal ileum, inflamed, rupture or cause a volvulus or intussusception
Mesenteric Adenitis - inflamed abdominal lymph nodes, preceding URTI acute
Appendix Mass

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17
Q

Management of acute appendicitis

A

Open Appendicectomy

Laparoscopic appendectomy

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18
Q

Complications of appendectomy

A

Bleeding, infection, pain and scars
Damage to bowel, bladder or other organs

Anaesthetic risks
Venous thromboembolism (deep vein thrombosis or pulmonary embolism)
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19
Q

Causes of IO

A

Adhesions (small bowel)
Hernias (small bowel)
Malignancy (large bowel)

Volvulus (large bowel)
Diverticular disease
Strictures (e.g., secondary to Crohn’s disease)
Intussusception

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20
Q

Causes of intestinal adhesion

A

Abdominal or pelvic surgery (particularly open surgery)
Peritonitis
Abdominal or pelvic infections (e.g., pelvic inflammatory disease)
Endometriosis

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21
Q

Causes of closed-loop obstruction

A

Adhesion
Hernia
Volvulus
Ileocaecal valve competency

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22
Q

Presentation of IO

A

Vomiting (particularly green bilious vomiting)
Abdominal distention
Diffuse abdominal pain
Absolute constipation and lack of flatulence
“Tinkling” bowel sounds may be heard in early bowel obstruction

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23
Q

Upper limits of normal bowel diameter

A

3 cm small bowel
6 cm colon
9 cm caecum

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24
Q

Distinguish small and large bowel on X-ray

A

Valvulae conniventes and central - small bowel

Haustration and peripheral - large bowel

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25
Complications of IO
Hypovolaemic shock due to fluid stuck in the bowel rather than the intravascular space (third-spacing) Bowel ischaemia Bowel perforation Sepsis
26
Initial management of IO
Nil by mouth IV fluid resuscitation NG tube with free drainage Abdominal x-ray Erect chest x-ray Contrast abdominal CT scan
27
Surgical intervention for IO
Conservative management as first instance in stable patients with obstruction secondary to adhesions or volvulus Exploratory surgery in patients with an unclear underlying cause Adhesiolysis to treat adhesions Hernia repair Emergency resection of the obstructing tumour
28
Causes of ileus
Injury to the bowel Handling of the bowel during surgery Inflammation or infection in, or nearby, the bowel (e.g., peritonitis, appendicitis, pancreatitis or pneumonia) Electrolyte imbalance (e.g., hypokalaemia or hyponatraemia)
29
S/S of ileus
Vomiting (particularly green bilious vomiting) Abdominal distention Diffuse abdominal pain Absolute constipation and lack of flatulence Absent bowel sounds (as opposed to the “tinkling” bowel sounds of mechanical obstruction)
30
Management of ileus
Nil by mouth or limited sips of water NG tube if vomiting IV fluids to prevent dehydration and correct the electrolyte imbalances Mobilisation to helps stimulate peristalsis Total parenteral nutrition (TPN) may be required whilst waiting for the bowel to regain function
31
2 major types of volvulus
Sigmoid volvulus | Caecal volvulus
32
Major cause of sigmoid volvulus
chronic constipation and lengthening of the mesentery attached to the sigmoid colon. The sigmoid colon becomes overloaded with faeces, causing it to sink downwards causing a twist.
33
Risk factors for volvulus
``` Neuropsychiatric disorders (e.g., Parkinson’s) Nursing home residents Chronic constipation High fibre diet Pregnancy Adhesions ```
34
Presentation of volvulus
Vomiting (particularly green bilious vomiting) Abdominal distention Diffuse abdominal pain Absolute constipation and lack of flatulence
35
Imaging for volvulus
Abdominal x-ray can show the “coffee bean” sign in sigmoid volvulus contrast CT scan for Dx
36
Management for volvulus
Laparotomy (open abdominal surgery) Hartmann’s procedure for sigmoid volvulus (removal of the rectosigmoid colon and formation of a colostomy) Ileocaecal resection or right hemicolectomy for caecal volvulus
37
Complications of hernias
Incarceration of bowel > obstruction and strangulation of the hernia Obstruction > vomiting, generalised abdominal pain and absolute constipation Strangulation > ischemic bowel
38
General management of abdominal wall hernias
Conservative management: hernia has a wide neck (low risk of complications) Tension-free repair (surgery): mesh over the defect in the abdominal wall, sutured to the muscles and tissues on either side of the defect, tissues grow into the mesh Tension repair (surgery): surgical operation to suture the muscles and tissue on either side of the defect back together
39
Ddx for lump in the inguinal region
``` Femoral hernia Lymph node Saphena varix (dilation of saphenous vein at junction with femoral vein in groin) Femoral aneurysm Abscess Undescended / ectopic testes Kidney transplant ```
40
Direct inguinal hernia: - Location, boundaries - Reducibility
Hesselbach’s triangle: (RIP mnemonic): R – Rectus abdominis muscle – medial border I – Inferior epigastric vessels – superior / lateral border P – Poupart’s ligament (inguinal ligament) – inferior border Pressure over the deep inguinal ring will not stop the herniation
41
Femoral hernia | - Explain the high risk of bowel complications (incarceration, obstruction, strangulation)
Involves herniation of bowel content through femoral canal Opening of femoral ring is narrow, and femoral canal is long and narrow
42
Boundaries of femoral canal
Boundaries of the femoral canal (FLIP mnemonic): F – Femoral vein laterally L – Lacunar ligament medially I – Inguinal ligament anteriorly P – Pectineal ligament posteriorly
43
Boundaries of femoral triangle
SAIL mnemonic: S – Sartorius – lateral border A – Adductor longus – medial border IL – Inguinal Ligament – superior border
44
Contents of the femoral canal
NAVY-C mnemonic ``` N – Femoral Nerve A – Femoral Artery V – Femoral Vein Y – Y-fronts C – Femoral Canal (containing lymphatic vessels and nodes) ```
45
Spigelian hernia | - Location
Spigelian hernia occurs between the lateral border of the rectus abdominis muscle and the linea semilunaris. At the site of the spigelian fascia, which is an aponeurosis between the muscles of the abdominal wall
46
Cause of diastasis recti
widening of the linea alba, the connective tissue that separates the rectus abdominis muscle congenital (in newborns) weakness in the connective tissue, for example following pregnancy or in obese patients
47
Obturator hernia - Location - Causes - Presentation
through the obturator foramen at the bottom of the pelvis defect in the pelvic floor and are more common in women, particularly in older age, after multiple pregnancies and vaginal deliveries may present with irritation to the obturator nerve: Howship–Romberg sign: pain extending from the inner thigh to the knee when the hip is internally rotated
48
Hiatus hernia presentation
Hiatus hernias present with dyspepsia (indigestion), with symptoms of: ``` Heartburn Acid reflux Reflux of food Burping Bloating Halitosis (bad breath) ```
49
Repair of hiatus hernia
laparoscopic fundoplication tying the fundus of the stomach around the lower oesophagus to narrow the lower oesophageal sphincter
50
Risk factors for haemorrhoids
pregnancy, obesity, increased age and increased intra-abdominal pressure (e.g., weightlifting or chronic coughing), constipation
51
4 degrees of haemorrhoids
1st degree: no prolapse 2nd degree: prolapse when straining and return on relaxing 3rd degree: prolapse when straining, do not return on relaxing, but can be pushed back 4th degree: prolapsed permanently
52
Symptoms of haemorrhoids
onstipation and straining. painless, bright red bleeding, typically on the toilet tissue or seen after opening the bowels. The blood is not mixed with the stool Sore / itchy anus Feeling a lump around or inside the anus
53
Examination for 2 types of haemorrhoids
External (prolapsed) haemorrhoids are visible on inspection as swellings covered in mucosa Internal haemorrhoids may be felt on a PR exam Prolapse if the patient is asked to “bear down” during inspection
54
Ddx of rectal bleeding
``` Haemorrhoids Anal fissures Diverticulosis Inflammatory bowel disease Colorectal cancer ```
55
Topical treatment of haemorrhoifs
``` Anusol (contains chemicals to shrink the haemorrhoids – “astringents”) Anusol HC (also contains hydrocortisone – only used short term) Germoloids cream (contains lidocaine – a local anaesthetic) Proctosedyl ointment (contains cinchocaine and hydrocortisone – short term only) ```
56
Non-surgical treatment of haemorrhoids
Rubber band ligation (fitting a tight rubber band around the base of the haemorrhoid to cut off the blood supply) Injection sclerotherapy (injection of phenol oil into the haemorrhoid to cause sclerosis and atrophy) Infra-red coagulation (infra-red light is applied to damage the blood supply) Bipolar diathermy (electrical current applied directly to the haemorrhoid to destroy it)
57
Surgical options for haemorrhoid
Haemorrhoidal artery ligation - involves using a proctoscope to identify the blood vessel that supplies the haemorrhoids and suturing it to cut off the blood supply. Haemorrhoidectomy - involves excising the haemorrhoid. Removing the anal cushions may result in faecal incontinence. Stapled haemorrhoidectomy - involves using a special device that excises a ring of haemorrhoid tissue at the same time as adding a circle of staples in the anal canal. The staples remain in place long-term.
58
1 complication of haemorrhoids | Presentation
Thrombosed Haemorrhoids caused by strangulation at the base of the haemorrhoid, resulting in thrombosis appear as purplish, very tender, swollen lumps around the anus.
59
Define diverticulum, diverticulosis, diverticulitis
diverticulum (plural diverticula) is a pouch or pocket in the bowel wall Diverticulosis refers to the presence of diverticula, without inflammation or infection. Diverticulitis refers to inflammation and infection of diverticula
60
Risk factors of diverticulosis
increased age. Low fibre diets, obesity and the use of NSAIDs
61
Typical presentation of diverticulosis | Management
Presentation: lower left abdominal pain, constipation or rectal bleeding Mx: increased fibre in the diet and bulk-forming laxatives, weight loss
62
Presentation of acute diverticulitis
Pain and tenderness in the left iliac fossa / lower left abdomen Fever Diarrhoea Nausea and vomiting Rectal bleeding Palpable abdominal mass (if an abscess has formed)
63
Complications of acute diverticulitis
Perforation Peritonitis Peridiverticular abscess Large haemorrhage requiring blood transfusions Fistula (e.g., between the colon and the bladder or vagina) Ileus / obstruction
64
Define foregut, midgut and hindgut blood supply
The foregut includes the stomach and part of the duodenum, biliary system, liver, pancreas and spleen. This is supplied by the coeliac artery. The midgut is from the distal part of the duodenum to the first half of the transverse colon. This is supplied by the superior mesenteric artery. The hindgut is from the second half of the transverse colon to the rectum. This is supplied by the inferior mesenteric artery.
65
Chronic mesenteric ischaemia - cause - typical triad of presentation - Diagnosis
Cause: narrowing of the mesenteric blood vessels by atherosclerosis - Central colicky abdominal pain after eating (starting around 30 minutes after eating and lasting 1-2 hours) - Weight loss (due to food avoidance, as this causes pain) - Abdominal bruit may be heard on auscultation Diagnosis is by CT angiography.
66
Risk factors for Chronic mesenteric ischaemia
``` Increased age Family history Smoking Diabetes Hypertension Raised cholesterol ```
67
Surgical Management of chronic mesenteric ischaemia
``` Endovascular procedures first-line (i.e. percutaneous mesenteric artery stenting) Open surgery (i.e endarterectomy, re-implantation or bypass grafting) ```
68
Acute mesenteric ischaemia - Cause - Presentation - Complication - Diagnosis
rapid blockage in blood flow through the superior mesenteric artery, thrombus or embolus acute, non-specific abdominal pain shock, peritonitis and sepsis, necrosis of the bowel tissue and perforation, metabolic acidosis and raised lactate Contrast CT is the diagnostic test
69
Risk factors for CRC
Family history of bowel cancer Familial adenomatous polyposis (FAP) Hereditary nonpolyposis colorectal cancer (HNPCC), Inflammatory bowel disease (Crohn’s or ulcerative colitis) ``` Increased age Diet (high in red and processed meat and low in fibre) Obesity and sedentary lifestyle Smoking Alcohol ```
70
Red flag signs for CRC
Change in bowel habit (usually to more loose and frequent stools) Unexplained weight loss Rectal bleeding Unexplained abdominal pain Iron deficiency anaemia (microcytic anaemia with low ferritin) Abdominal or rectal mass on examination
71
Screening test for CRC
Faecal immunochemical tests (FIT)
72
Investigations for CRC
Colonoscopy is the gold standard Sigmoidoscopy (for rectal bleeding only presentation) CT colonography Staging CT scan involves a full CT thorax, abdomen and pelvis (CT TAP) - metastasis Carcinoembryonic antigen (CEA) - tumour marker
73
Surgical treatment options for CRC
Open or Laparoscopic
74
5 types of colon resection
Right hemicolectomy - removal of the caecum, ascending and proximal transverse colon. Left hemicolectomy - removal of the distal transverse and descending colon. High anterior resection - removing the sigmoid colon (may be called a sigmoid colectomy). Low anterior resection - removing the sigmoid colon and upper rectum but sparing the lower rectum and anus. Abdomino-perineal resection (APR) - removing the rectum and anus (plus or minus the sigmoid colon) and suturing over the anus
75
Complication of bowel surgery
``` Bleeding, infection and pain Damage to nerves, bladder, ureter or bowel Post-operative ileus Anaesthetic risks Laparoscopic surgery converted during the operation to open surgery (laparotomy) Leakage or failure of the anastomosis Requirement for a stoma Failure to remove the tumour Change in bowel habit Venous thromboembolism (DVT and PE) Incisional hernias Intra-abdominal adhesions ```
76
4 types of stoma, compare function and differences
Colostomy - LIF, flush to skin, solid stool Ileostomy - RIF, sprouted, liquid stool Gastrostomy (PEG) - feeding directly into stomach Urostomy - RIF, ileal conduit, after cystectomy
77
Surgeries that precede end ileostomy/ end colostomy
End colostomies are permanent after resection of abdomino-perineal resection (APR) - entire rectum and anus removed End ileostomies are permanent after a panproctocolectomy (total colectomy with removal of the large bowel, rectum and anus)
78
Function of loop colostomy/ loop ileostomy
temporary stoma used to allow a distal portion of the bowel and anastomosis to heal after surgery “covering” or “defunctioning” loop colostomy or ileostomy, as they allow faeces to bypass the distal, healing portion of bowel until healed and ready to restart normal function.
79
Complications of stomas
Psycho-social impact Local skin irritation Parastomal hernia Loss of bowel length leading to high output, dehydration and malnutrition Constipation (colostomies) Stenosis Obstruction Retraction (sinking into the skin) Prolapse (telescoping of bowel through hernia site) Bleeding Granulomas causing raised red lumps around the stoma
80
Risk factor for gallstones
F – Fat F – Fair F – Female F – Forty
81
Typical presentation of gallstones
biliary colic Severe, colicky epigastric or right upper quadrant pain Often triggered by meals (particularly high fat meals) Lasting between 30 minutes and 8 hours May be associated with nausea and vomiting
82
Complications of gallstones
Acute cholecystitis Acute cholangitis Obstructive jaundice (if the stone blocks the ducts) Pancreatitis
83
Investigations and treatment for gallstones
Ultrasound (first-line) - diagnostic only A magnetic resonance cholangio-pancreatography (MRCP) - diagnostic only endoscopic retrograde cholangio-pancreatography (ERCP) - diagnostic and therapeutic Cholecystectomy (open or laproscopic) - therapeutic only
84
Complications of ERCP
Excessive bleeding Cholangitis (infection in the bile ducts) Pancreatitis
85
Procedures performed through ERCP
Inject contrast and take x-rays to visualise the biliary system and diagnose pathology (e.g., stones or strictures) Perform a sphincterotomy on the sphincter of Oddi if it is dysfunctional (blocking flow) Clear stones from the ducts Insert stents to improve bile duct drainage (e.g., with strictures or tumours) Take biopsies of tumours
86
Complications of cholecystectomy?
Bleeding, infection, pain and scars Damage to the bile duct including leakage and strictures Stones left in the bile duct Damage to the bowel, blood vessels or other organs Anaesthetic risks Venous thromboembolism (deep vein thrombosis or pulmonary embolism) Post-cholecystectomy syndrome
87
Define post-cholecystectomy syndrome
Symptoms after cholecystectomy, may be attributed to changes in the bile flow after removal of the gallbladder ``` Diarrhoea Indigestion Epigastric or right upper quadrant pain and discomfort Nausea Intolerance of fatty foods Flatulence ```
88
Acute cholecystitis - Causes (2) - Typical presentation
gallstones (calculous cholecystitis) - 95% acalculous cholecystitis - functional disability due to TPN or long fasting periods right upper quadrant (RUQ). This may radiate to the right shoulder. Fever Nausea Vomiting Tachycardia (fast heart rate) and tachypnoea (raised respiratory rate) Right upper quadrant tenderness Murphy’s sign Raised inflammatory markers and white blood cells
89
Specific sign for acute cholecystitis
Murphy’s sign is suggestive of acute cholecystitis: - Place a hand in RUQ and apply pressure - Ask the patient to take a deep breath in - The gallbladder will move downwards during inspiration and come in contact with your hand - Stimulation of the inflamed gallbladder results in acute pain and sudden stopping of inspiration
90
Investigations for acute cholecystitis
1) abdominal ultrasound scan: Thickened gallbladder wall Stones or sludge in gallbladder Fluid around the gallbladder 2) Magnetic resonance cholangiopancreatography (MRCP)
91
Management of acute cholecystitis
``` Conservative management involves: Nil by mouth IV fluids Antibiotics (as per local guidelines) NG tube if required for vomiting ``` Endoscopic retrograde cholangio-pancreatography (ERCP) Cholecystectomy
92
Complications of acute cholecystitis
Sepsis Gallbladder empyema Gangrenous gallbladder Perforation
93
2 main causes of acute cholangitis Common pathogens (3)
Obstruction in the bile ducts Infection introduced during an ERCP procedure Escherichia coli Klebsiella species Enterococcus species
94
Triad of symptoms for acute cholangitis
Right upper quadrant pain Fever Jaundice (raised bilirubin)
95
Acute management and initial investigations of acute cholangitis
1) Acute management of sepsis and acute abdomen, including: Nil by mouth IV fluids Blood cultures IV antibiotics (as per local guidelines) Involvement of seniors and potentially HDU or ICU 2) Imaging to diagnose common bile duct (CBD) stones and cholangitis Magnetic resonance cholangio-pancreatography (MRCP) Endoscopic ultrasound
96
Treatment of acute cholangitis
endoscopic retrograde cholangio-pancreatography (ERCP): contrast, stone removal, balloon dilatation, stenting, biopsy Percutaneous transhepatic cholangiogram (PTC) involves radiologically guided insertion of a drain through the skin and liver, into the bile ducts
97
Cholangiocarcinoma - Histological type - Location (most common) - Risk factors
adenocarcinomas inside the liver (intrahepatic ducts) or outside the liver (extrahepatic ducts) most common site is in the perihilar region Ulcerative colitis Primary sclerosing cholangitis Liver flukes (a parasitic infection)
98
Presentation of cholangiocarcinoma
Obstructive jaundice: Pale stools Dark urine Generalised itching Unexplained weight loss Right upper quadrant pain Palpable gallbladder (swelling due to an obstruction in the duct distal to the gallbladder) Hepatomegaly
99
Explain courvoisier's law
palpable gallbladder along with jaundice is unlikely to be gallstones. The cause is usually cholangiocarcinoma or pancreatic head cancer.
100
Investigations for cholangiocarcinoma
Diagnosis is based on imaging (CT or MRI) plus histology from a biopsy. Staging CT scan involves a full CT thorax, abdomen and pelvis (CT TAP) CA 19-9 (carbohydrate antigen) is a tumour marker that may be raised in cholangiocarcinoma. It is also raised in pancreatic cancer Magnetic resonance cholangio-pancreatography (MRCP) Endoscopic retrograde cholangio-pancreatography (ERCP)
101
Management of cholangiocarcinoma
Stents inserted to relieve the biliary obstruction Surgery to improve symptoms (e.g., bypassing the biliary obstruction) Palliative chemotherapy Palliative radiotherapy End of life care with symptom control
102
Pancreatic cancer | - Typical presentation
``` - Painless obstructive jaundice: Yellow skin and sclera Pale stools Dark urine Generalised itching ``` - other presenting features: Non-specific upper abdominal or back pain Unintentional weight loss Palpable mass in the epigastric region Change in bowel habit Nausea or vomiting New‑onset diabetes or worsening of type 2 diabetes
103
Trousseau’s sign of malignancy?
refers to migratory thrombophlebitis as a sign of malignancy, particularly pancreatic adenocarcinoma
104
Investigations for pancreatic cancer
imaging (usually CT scan) plus histology Staging CT scan involves a full CT thorax, abdomen and pelvis (CT TAP) CA 19-9 (carbohydrate antigen) Magnetic resonance cholangio-pancreatography (MRCP) Endoscopic retrograde cholangio-pancreatography (ERCP) Biopsy under US or CTG
105
Management of pancreatic cancer (4 types of surgical treatment)
Total pancreatectomy Distal pancreatectomy Pylorus-preserving pancreaticoduodenectomy (PPPD) (modified Whipple procedure) Radical pancreaticoduodenectomy (Whipple procedure)
106
Palliative treatment for pancreatic cancer
Stents inserted to relieve the biliary obstruction Surgery to improve symptoms (e.g., bypassing the biliary obstruction) Palliative chemotherapy (to improve symptoms and extend life) Palliative radiotherapy (to improve symptoms and extend life) End of life care with symptom control
107
Describe extent of organ removal in whipple procedure
Whipple procedure (pancreaticoduodenectomy) ``` Head of the pancreas Pylorus of the stomach Duodenum Gallbladder Bile duct Relevant lymph nodes ```
108
Describe modified whipple procedure
pylorus-preserving pancreaticoduodenectomy (PPPD). ``` Removing: Head of the pancreas Duodenum Gallbladder Bile duct Relevant lymph nodes ```
109
3 most common causes of acute pancreatitis
Gallstones (bile reflux back into pancreas) Alcohol (direct toxicity) Post-ERCP ``` Others: S – Steroids T – Trauma A – Autoimmune M – Mumps ```
110
Typical presentation of acute pancreatitis
``` Severe epigastric pain Radiating through to the back Associated vomiting Abdominal tenderness Systemically unwell (e.g., low-grade fever and tachycardia) ```
111
Investigations for acute pancreatitis
``` - Glasgow score: FBC (for white cell count) U&E (for urea) LFT (for transaminases and albumin) Calcium ABG (for PaO2 and blood glucose) ``` - Severity: serum amylase 3x upper limit of normal CRP Ultrasound CT abdomen for complications (such as necrosis, abscesses and fluid collections)
112
Criteria for Glasgow score
PANCREAS mnemonic (1 point for each answer): ``` P – Pa02 < 8 KPa A – Age > 55 N – Neutrophils (WBC > 15) C – Calcium < 2 R – uRea >16 E – Enzymes (LDH > 600 or AST/ALT >200) A – Albumin < 32 S – Sugar (Glucose >10) ```
113
Management of acute pancreatitis
Management involves: Initial resuscitation (ABCDE approach) IV fluids Nil by mouth Analgesia Careful monitoring Treatment of gallstones in gallstone pancreatitis (ERCP / cholecystectomy) Antibiotics if there is evidence of a specific infection (e.g., abscess or infected necrotic area) Treatment of complications (e.g., endoscopic or percutaneous drainage of large collections)
114
Complications of acute pancreatitis
``` Necrosis of the pancreas Infection in a necrotic area Abscess formation Acute peripancreatic fluid collections Pseudocysts (collections of pancreatic juice) can develop 4 weeks after acute pancreatitis Chronic pancreatitis ```
115
Complications of chronic pancreatitis
``` Chronic epigastric pain lack of pancreatic enzymes Loss of insulin, leading to diabetes strictures resulting in obstruction of pancreatic juice and bile pseudocysts or abscesses ```
116
Management of chronic pancreatitis
Abstinence from alcohol and smoking Analgesia Replacement pancreatic enzymes (Creon) Subcutaneous insulin regimes ERCP with stenting Surgery for complications (chronic pain, biliary obstruction, abscess...)
117
Contraindication for liver transplant
Significant co-morbidities (e.g., severe kidney, lung or heart disease) Current illicit drug use Continuing alcohol misuse (generally 6 months of abstinence is required) Untreated HIV Current or previous cancer (except certain liver cancers)