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Surgery > Surgery - Pre and Post Op Care, Electrolytes > Flashcards

Surgery - Pre and Post Op Care, Electrolytes Flashcards

1
Q

How to decrease risk of surgical site infections

A

Hair removal w/ clippers (not razors)

Warm room temperature (will have more blood flow to skin)

Tight blood flucose control

Abx ppx

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2
Q

Common causes of post-op fever and the days of these causes

A

5Ws = wind, water, walking, wound, wonder drugs

1-2 d = Atelectasis (#1), PNA

3-5 d = UTI

4-6 d = DVT

5-7d = wound infection

> 7d = medications (drug fever)

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3
Q

Most common cause of post-op drug fever

A

Anticonvulsants

TMP/SMX

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4
Q

How much isotonic fluid do you give per amount of blood lost?

A

3 mL!

If lose 500 mL blood, give 500 x 3 = 1500 mL isotonic fluid (NS or LR)

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5
Q

normal urine output

A

0.5-1 mL/ kg / hr

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6
Q

Most common cause of fever in immediate post op period

2nd most common?

A

1 - Atelectasis

2 - UTI

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7
Q

Preop characteristics of pts likely to experience postop ischemia after noncardiac surgery

A
  1. JVD - tx w ACEi, Bblockers, digitalis, diuretics
  2. MI in last 6 mo (< 6% after 6 mo, 40% within 3 mo)
>70yo
Mitral regurg / aortic stenosis
> 5 PVC / min
Tortuous or calcified aorta
EF < 35%
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8
Q

Perioperative stroke results…

A

mortality after post op stroke is high

NOT related to hx of multiple strokes or poststroke TIAs

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9
Q

Transfusions of blood through

  • hypotonic solutions
  • ringers lactate

what happens?

A

Hypotonic (D5W / NS)
- swelling of erythrocytes and lysis

Ringers lactate
- has Ca and causes clotting in IV line –> PE can happen

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10
Q

How long after cig abstinence do you get improvement in postop respiratory morbidity?

A

6-8 weeks

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11
Q

Preop hepatic risk - predictors of mortality

A 
Bilirubin
Serum albumin
PT 
Ascites
Encephalopathy
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12
Q

Tx malignant hyperthermia

A

T > 104

Quickly finish surgery
Stop anesthesia
Hyperventilate w/ 100% O2
\+ IV dantrolene
alkalinize urine to prevent myoglobin precipitation
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13
Q

When do you see bacteremia post op?

Tx?

A

30-45 mins after

BCx x 3
Start empiric abx

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14
Q

When do you get periop MI?

A

within 1st 2-3 days post op

Trend troponins

Greater mortality than non-surgery induced MI

Tx directed at complications (no tPA)

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15
Q

Pulmonary embolus findings

A

Tachycardia (1st sign)

SOB
Diaphoretic

ABG

  • hypoxemia
  • hypogapnia
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16
Q

1st thing suspect when post op pt gets confused and disoriented?

Other things?

A

1 = Hypoxia ; Can be 2/2 sepsis

Others:
ARDS
DTs
Hyponatremia
Hypernatremia
Ammonium intoxication (in cirrhotic pts)
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17
Q

AKI FeNa of:

  • prerenal
  • renal
  • postrenal
A

Prerenal < 1

Renal > 2

Postrenal > 2

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18
Q

AKI BUN/Cr of:

  • prerenal
  • renal
  • postrenal
A

Prerenal >20

Renal 15

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19
Q

What can paralytic ileus be prolonged by?

A

Hypokalemia

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20
Q

Tx early post op obstruction

A
  • Occurring within 30 days of open operation
  • Management is conservative and most resolve spontaneously
  • Will not go in early on b/c collagen deposition is happening to fix the cuts made during surgery and that will be very hard to get through. Go back in about 6 weeks is safe
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21
Q

Risk of wound dehiscence

A

Dehiscence is fascia is not properly sewn together

Can get evisceration –> skin opens up and all ab contents flow out

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22
Q

Factors assoc w / failure of fistula to heal

A

FRIEND

Foreign body in wound
Radiation damage to area
Infection or inflammatory bowel disease
Epithelialization of fistulous tract
Neoplasm
Distal bowel obstruction
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23
Q

Wound healing process

A

Inflammation - Proliferation - Remodeling

Inflammatory

  • rapid influx of neutrophils
  • then monocytes to phagocytose debris and bacteria and secrete TNF, TGF, PDGF, FGF

Proliferation

  • angiogenesis + collagen formation
  • fibroblasts enter @ day 3 to lay down collagen
  • type 3 collagen (elastic fibrils) predominates
  • replaced by type 1 collagen (rigid)

Remodeling
- collagen deposition and degradation reach steady state at ~ 1yr

1) Collagen
- needs to be crosslinked by fibroblasts
- fibroblasts also contract w/ SM elements called myofibroblasts –> can result in contractures

2) Growth factors
- PDGF
- neutrophils
- macrophages
- TGF-B
- Epithelial growth factor

24
Q

When do you need perioperative abx?

A

Contaminated

Clean-contaminated wounds

25
Epithelialization vs wound contraction
Epithelialization responsible for healing of closed incision (usually w/in 48 hrs after incision) Wound contraction is primary method of closure in open wounds - can cause 90% reduction in size of open wound but varies if tight skin adherence is present (eg in leg) - fibroblasts proliferate becoming myofibroblasts and contract wound - bacteria colonization does not harm process
26
Wound healing cytokines
Injury: platelets release -- - ADP - TXA - TGF - PDGF Macrophages release - - IL1 - FGF - TGF - EGF - Plasminogen activator inhibitor Collagen synthesis initiated and progresses upon stimulation by IL-1 TNF TGF
27
Tx hypernatremia
- Volume repletion so that vol is corrected fast but tonicity is slower to correct - use D5 1/2 NS
28
Tx hyponatremia
If due to SIADH, water restriction Otherwise, use 3% saline or Ringer lactate
29
Tx hypokalemia
IV K @ 10 mEq/h (try not to exceed)
30
Causes of hyperkalemia
Renal dysfunction Acidemia Tumor lysis
31
Tx hyperkalemia
C BIG K CaCl2 (cell membrane stabilization) Bicarb Beta agonist Insulin (insulin and glucose are the fastest - give glucose too to avoid hypoglycemia) D50 (glucose) Kayexalate Dialysis is ultimate therapy
32
What med for hyperkalemia counteracts myocardial effects of K w/o reducing serum K level?
Calcium gluconate
33
Hypocalcemia - symptoms - patho phys
"CATS go numb"- Convulsions, Arrhythmias (QT prolongation), Tetany and numbness/parasthesias in hands, feet, around mouth and lips The neuromuscular symptoms of hypocalcemia are caused by decreased interaction of calcium with sodium channels. Since calcium blocks sodium channels and inhibits depolarization of nerve and muscle fibers, diminished calcium lowers the threshold for depolarization
34
Tx hypercalcemia
Hyper Ca results in osmotic diuresis making hyper Ca worse 1) rehydrate w/ normal saline 2) furosemide for Ca diuresis if volume overload 3) + bisphosphonates longterm 4) Tx underlying cause Only need to manage immediately severe hypercalcemia. Mild and moderate is treated only if symptomatic
35
When see SEVERE hypermagnesemia? What's the earliest clinical indication of hyperMg?
- Advanced renal failure treated w/ Mg- antacids - OBs +MgSO4 for preeclampsia Loss of deep tendon reflexes - docs give pts MgSO4 until see this
36
Hypermagnesemia clinical findings
``` HypoTN (arteriolar relaxing) Paralysis Resp depression Changes in Mental status N/V ```
37
Hypomagnesemia clinical findings
Like hypo Ca BUT get torsades! ``` Paresthesia Hyperreflexia Muscle spasm Tetany K wasting by kidney functional hypoPTH --> lowers serum Ca ``` Happens in malnourished pts, pts w/ large GI fluid losses
38
How to rapidly differentiate hypo Ca vs. hypo Mg
EKG
39
Why do we give D5 1/2 NS + KCl to patients? How do you calculate how much maintenance fluid to give someone?
Prevent ketosis with glucose! 1/2 Normal saline is hypoosmotic fluid and is maintenance fluid to make it isoosmotic with D5 ``` Calculating maintenance fluid: 4-2-1 1st 10 kg --> give 4 cc/kg/hr Next 10 kg --> give 2 cc/kg/hr Remainder of weight --> give 1 cc/kg/hr ``` Trick for hourly maintenance = 40 + weight (kg)
40
Laproscopic surgery | - risks
- CO2 used in laparoscopy b/c better solubility in blood so less risk of gas embolism. Also noncombustible Risks for pneumoperitoneum: o CO2 embolus in pulmonary artery o HypoTN 2/2 compression of IVC
41
Insulin-dep Diabetic pt pre-op
Check glucose AM of surgery - better to be slightly increased glucose If gluc > 250 --> + 2/3 AM dose of NPH + reg insulin If gluc < 250 --> + 1/2 AM dose Make sure glucose is below 250 mg/dL preop - delay if not so
42
Hypercalcemia causes
``` Hyper PTH mets to bone Multiple myeloma Hyper TH sarcoidosis Vit A intoxication Thiazides RCC SCC of lung (PTrH) Hypocalciuric hypercalcemia ```
43
Secretion of parathyroid hormone is controlled chiefly by
serum [Ca2+] through negative feedback. Calcium-sensing receptors located on parathyroid cells are activated when [Ca2+] is low. Gq receptors!!!! PIP
44
hypercalcemia symptoms
``` Nausea vomiting dehydration lethargy confusion kidney stones (#1) cardiac effects - HTN, LVH, calcification of valves Peptic ulcers Pancreatitis ```
45
Tx hypovolemic hypernatremia - mild - severe
Mild: D5W + 1/2 NS Severe: NS, then switch to 1/2 NS
46
CEntral pontine myleinolysis consequence of
hyponatremia corrected too fast
47
Correct hypernatremia too fast...
Cerebral edema
48
Tx euvolemic or hypervolemic hypernatremia
D5W IV free water may cause RBC lysis b/c osmotic shock
49
S/E loop diuretics
Hypokalemia Metabolic alkalosis Prerenal renal failure
50
Changes in calcium binding w/ pH
Alkalosis (increase pH) --> more albumin binds calcium, therefore less free calcium Free calcium is the only active form!
51
When can you start heparin/dvt ppx on a post op patient without increased risk of bleeding?
48-72 hrs after operation is safe if they are hemodynamically stable
52
Pt NPO for a while + receiving broad spectrum abx. Starts to bleed from IV site. PT and PTT prolonged. What happened?
Vit K deficiency No food --> no vit K intake Abx --> get rid of bacteria --> no make Vit K PT will usually be more elevated than PTT
53
Meds causing hyperkalemia
``` Beta blockers ACE inhibitors, ARBs Digitalis Cyclosporine Heparin NSAIDs Succinylcholine TMP/SMX ```
54
Causing hypokalemia
Alkalosis Insulin Beta agonist
55
S/E TMP
Hyperkalemia INhibit renal tubular Cr secretion (artificial increase in serum Cr)
56
Tx TCA overdose
Bicarb - shortens QRS interval TCA od usually has CNS depression, hypoTN, hyperthermia, and anticholinergic effects (dilated pupils, dry flushed skin, intestinal ileus)

Surgery (12 decks)

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