Surgery - Breast Flashcards

1
Q

US for breast best to detect masses of what size?

A

> 1cm in diameter

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2
Q

Acute mastitis

  • causes
  • description
  • tx
A

Usually due to S. aureus. It is a cellulitis (vs breast abscess needing drainage)

Need to r/o breast cancer!

Dicloxacillin
Cephalosporins

Cont breast feeding as can dec progression of mastitis to breast abscess

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3
Q

Mammo guidelines

A
  • Should start at age 40

- DO NOT DO before 20 (breast too dense) or lactation (all is milk)

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4
Q

Fibroadenoma

  • description
  • management
A

Young women (< 35 yo)
Firm, mobile, rubbery mass
Increase size/tenderness with menstruation

FNA
Sonogram
OPTIONAL removal

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5
Q

Giant juvenile fibroadenomas

  • description
  • management
A

Young adults
Rapid growth

YES remove
To avoid deformity and distortion of breast

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6
Q

Cystosarcoma phyllodes

  • description
  • management
A

30-50 yo
LARGE bulky mass that is mobile and arises from lobular tissue
Most benign, but can turn malignant

Core or incisional bx
YES remove

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7
Q

Fibrocystic disease

  • description
  • management
A
30s-40s
Tender + grow w/ menstrual cycle
Usually not increase risk of carcionma
Diff histo types:
- fibrosis
- cystic
- sclerosing adenosis (microcalcificatiosn on mammo)
- epithelial hyperplasia

Mammo if no dominant or persistent mass
If persistent mass –> aspiration (not FNA)
If aspiration doesn’t disappear –> formal bx needed

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8
Q

Intraductal papilloma

  • description
  • management
A

Young women
Grows in lactiferous ducts
No increased cancer risk
Bloody nipple discharge

Mammogram to ID other lesions – will not show papilloma b/c too tiny
Galactogram (dx and for surgery resection)

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9
Q

Breast abscess

  • description
  • management
A

In lactating women

I & D
Bx of abscess wall

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10
Q

Treatment for breast cancer during pregnancy

A

No radiation
No chemo in 1st trimester
OK to keep pregnancy

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11
Q

DCIS

  • description
  • management
A

Can’t mets
Usually looks like microcalcifications on mammo
comedo has highest malignant potential

Diffuse lesions: Total simple mastectomy + Sentinel node bx

1 lesion: Lumpectomy + radiation

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12
Q

Breast cancer – resectable
- what do you do?

How about if not resectable?

A

Resectable:
Lumpectomy + axillary sampling + postop rad
Modified radical mastectomy + axillary sampling (sentinel lymph nodes)

Not resectable:
Chemo

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13
Q

Breast Cancer mets

  • where does it go?
  • dx?
  • Tx?
A

Brain

<3 vertebral pedicles

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14
Q

Tx breast cancer in premenopausal? postmen?

A

Pre = tamoxifen

Post = anastrozole

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15
Q

Breast Cancer stage I

A

Tumor ≤ 2cm in diam
(-) mets
(-) nodes

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16
Q

Breast Cancer stage IIA

A

Tumor ≤ 2cm in diam + mobile axillary nodes
OR
Tumor 2-5 cm in diam, (-) nodes

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17
Q

Breast Cancer stage IIB

A

Tumor 2-5cm in diam + mobile axillary nodes
OR
Tumor > 5 cm, (-) nodes

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18
Q

Breast Cancer stage IIIA

A

Tumor > 5cm + mobile axillary nodes
OR
Any size + fixed axillary nodes, (-) mets

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19
Q

Breast Cancer stage IIIB

A
Peau d’orange       OR
Chest wall invasion/fixation       OR
Inflammatory cancer      OR
Breast skin ulceration     OR
Breast skin satellite mets    OR
Any tumor + ipsilateral internal mammary lymph nodes
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20
Q

Breast Cancer stage IIIC

A

Any size tumor, (-) mets

+ supraclavicular, infraclavicular, or internal mammary lymph nodes

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21
Q

Breast Cancer stage IV

A
Distant mets (including ipsilateral supraclavicular nodes)
-	Loves: lymph nodes, lung/pleura, liver, bones, brain
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22
Q

Metastatic breast cancer to bone - test to dx?

A

MRI

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23
Q

Mammo results w/ strong correlation with breast cancer

A

(1) breast calcifications that are
(a) smaller than 2 mm,
(b) punctate, microlinear, or branching,
(c) clustered along ducts or concentrated in clusters >5 calcifications per square centimeter;

(2) stellate-shaped lesions;
(3) masses with ill-defined borders or nodular contours;
(4) solitary dominant masses that are significantly larger than any other mass in either breast; and
(5) areas of increased noneffacing tissue density or distorted breast architecture.

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24
Q

What do breast cysts look like on mammo?

How do you confirm the nature of theses cysts?

A

Round, well-circumscribed densities

Confirm w/ breast US

25
Breast cyst suspicion - what do you do?
Aspirate and cytologic exam of cyst fluid If lesions don't disappear w/ aspiration ---> excise
26
BRCA 1 and 2 - associations
BRCA 1 - breast + ovarian BRCA 2 - breast
27
Breast cancer screening for non-high risk pts
Monthly breast self exam @20 Mammo @ 40 q 1-2 yrs until 50 Mammo @ 50 q 1 year
28
Breast cancer screening for high risk pts
Initial mammo at 30 q 1-2 yrs until 40 | Mammo @ 40 q 1 year
29
Diffuse + multicentric DCIS - tx?
Simple masectomy w/ or w/o reconstruction
30
Small breast lesion - cancer - tx?
Wide excision + Radiotherapy
31
LCIS - chance to develop into invasive cancer over 20 years?
15-20% It is incidental finding in histopath It is a malignant disease marker
32
Tx LCIS
close observation Exam + mammo q 6 months for the next several years
33
What things are essential to est in breast cancer?
Dx Completely eradicate primary tumor Determine if lymph node involvement Determine if mets present
34
Arterial supply to breast Venous return
Internal mammary Lateral thoracic artery Veins: - axillary - internal mammary veins
35
What is a modified radical mastectomy
Remove - breast tissue - skin - axillary lymph nodes Spares - pec major
36
Simple masectomy
Removes: - breast tissue - nipple-areolar complex - skin
37
Borders of the breast for masectomy
``` Superior - clavicle Inferior - inframammary fold Medial - sternum Lateral - latissimus dorsi Posterior - pec major ```
38
Borders of axilla
Superior - axillary v Posterior - Long thoracic N Lateral - latissius dorsi Medial - pec minor
39
Levels of axillary lymph nodes
1 - lateral to pec minor 2 - deep to pec minor 3 - medial to pec minor higher level of involvement, worse prognosis
40
How do you evaluate sentinel node?
INject blue vital dye or Technetium - 99 labeled sulfur colloid around primary tumor - will go to axillary lymph nodes Gammaprobe will ID radiotracer
41
Contraindications to reconstructiton after mastectomies
Primary lesions involving chest wall Extensive local or regional disease Stage 3 or 4 cancer
42
Tx Stage 0, 1 (< 1cm) stage tumors
Lumpectomy axillary sampling Radiation
43
Tx Stage 1 w/ larger tumors (1-2 cm)
Lumpectomy axillary sampling post-op radiation adjuvant therapy (based on ER status and menopause)
44
Tx Stage 2 cancer
Lumpectomy axillary sampling post-op radiation adjuvant therapy (based on ER status and menopause) OR modified radical masectomy
45
Development of coma in pt w/ hx of breast cancer - what should you be suscpicious abotu?
Hyperacalcemia!!!
46
Who gets offered chemotherapy?
Stage 2 or greater they ahve a 33-44% risk of recurrence of disease at 20 years w/ locoregional control only Usually do" - 5-FU/doxorubicin/cyclophosphamide - Taxol - trastuzumab
47
How long do you give antiestrogen therapy for pts w/ ER or PR + tumors?
5 years
48
What are the benefits of neoadjuvant therapy? Does it make a difference?
This is chemo before surgery Improvements in breast conservation rate + better cosmetic results NO shown survival difference
49
Tamoxifen s/e
uterine cancer
50
DCIS vs invasive ductal - what is difference?
Both from ductal hyperplasia But DCIS is without basement membrane penetration Both are more likely to be unilateral breast (vs bilateral in lobular)
51
Paget's disease
Eczematous patches on nipple Usually has undelrying DCIS
52
Reasons for gynecomastia in men
Hyperestogenism - cirrhosis - testicular tumor - puberty Kleinfelter's ``` Drugs: SDCAK Spironolactome Digitalis Cimetidine Alcohol Ketoconazole ``` Steroids
53
Tx inflammatory carcinoma of breast
Chemo first Then radiation + masectomy
54
Causes of bloody nipple discharge Next step
Intraductal papilloma Ductal ectasia Carcionma --> B/l mammo + US
55
Ddx of nipple discharge (all kinds)
``` Pregnancy Infections (mastitis/abscess) Pituitary adenoma Meds (metoclopramide, TCAs, OCPs) Hypothyroidism Fibrocystic changes Intraductal papilloma (usually unilateral) Diffuse papillomatosis (serous discharge, increased risk of cancer) Carcionma ``` Can use ductogram for some to figure out if the etiology is in duct!
56
How do you tell if there is a bit of blood in a discharge?
Hemoccult test
57
When can you do a ductogram?
ONLY if they have active discharge IF abnormal, need surgical bx If normal, may suggest underlying carcionma
58
Most common factor increasing risk of breast cancer
having 1 or more 1st degree relatives who have had breast cancer
59
Atypical ductal hyperplasia - characteristics - management
Hyperplasia of ducts of lobules Looks like DCIS Assoc cancer risk is 4-5x higher Management: - core bx --> shows atypical ductal hyperplasia --> needle loc + excision