Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Hem/Onc > Surface Markers and Translocations > Flashcards

Surface Markers and Translocations Flashcards

1
Q

t(9;22)

A

B-ALL, poor prognosis, seen in adults (“Adults are more likely to “Phall”)
and CML
ABL (9) –> BCR (22) Philadelphia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

t(12;21)

A

B-ALL, good prognosis, seen in adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

t(8;14)

A

Burkitt Lymphoma

cMyc (8) –> IgH (14)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

t(11;14)

A

Mantle Cell Lymphoma (G1–>S)

Cyclin D or CCND1 (11) –> IgH (14)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

t(14;18)

A 
Follicular Lymphoma (B cells)
BCl2 (18) --> IgH (14)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

B-ALL gene mutation (children bad prognosis)

A

t(9;22)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

B-ALL, gene mutation (adults, good prognosis)

A

t(12;21)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Burkitt Lymphoma gene mutaiton

A

t(8;14)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Mantle Cell Lymphoma gene mutation

A

t(11;14)

Cyclin D or CCND1 (11) –> IgH (14)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Follicular Lymphoma (B cells) gene mutation

A

t(14;18)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

CD16 association

A

Fc Receptor on neutrophils. Decreased levels are a sign of “left shift” or release of immature cells in neutrophilic leukocytosis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CD10, CD19, CD20, CD22 association

A

(And Tdt+) = B-ALL, the most common type of ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CD2 through CD8 association

A

(and TdT+) = T-ALL

CD10 negative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MPO+ exists on…

A

Myeloblasts (upregulated in AML)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Tdt+ exists on…

A

Lymphoblasts (Upregulated in ALL)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Increased IL-5 production associated with…

A

Eosinophelia, sign of allergic reaction, associated with Hodgkin Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Basophilia associated with…

A

Associated with CML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Fc Receptor on neutrophils associated with what marker?

A

CD16

Decreased levels are a sign of “left shift” or release of immature cells in neutrophilic leukocytosis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

B-ALL surface marker

A

CD10, CD19, CD20, CD22, Tdt+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

T-ALL surface marker

A

CD2 through CD8, Tdt+, CD10 NEGATIVE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Myeloblasts (upregulated in AML) surface marker

A

MPO+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Lymphoblasts (Upregulated in ALL) surface marker

23
Q

Associated with CML…

A

Basophilia

24
Q

t(15;17)

A

Acute promyelocytic Leukeia (an AML)
Retinoic acid receptor (17) –> 15
RAR disruption blocks maturation and promyelocytes (blasts) accumulate
- Auer Rods increase risk of DIC by activating coag. cascade
- Treated with ATRA, vit.A derivative
- may lead to ATRA syndrome

25
Acute promyelocytic Leukeia mutation
t(15;17) Acute promyelocytic Leukeia (an AML) Retinoic acid receptor (17) --> 15 RAR disruption blocks maturation and promyelocytes (blasts) accumulate - Auer Rods increase risk of DIC by activating coag. cascade. - Treated with ATRA, vit.A derivative - may lead to ATRA syndrome
26
Gum Swelling association
AML, specifically Acute monocytic leukemia | Proliferation of monoblasts, lack MPO usually
27
Associated w Down's Syndrome before age 5
AML, specifically acute megakaryoblastic leukemia | Proliferation of megakaryoblasts, lack MPO
28
Acute monocytic leukemia gene mutation
t(9;11), t(11;19), del (11q)
29
CLL surface marker
CD5 (normally a T cell marker) CD20 coexpression
30
CD5 and CD20 coexpression association
Chronic Lymphocytic Leukemia (CLL)
31
smudge cells association
CLL
32
TRAP+ association
TRAP = Tartrate-resistant acid phosphatase | TRAP+ cells seen in Hairy Cell Leukemia (B cells)
33
Marker for Hairy Cell Leukemia
TRAP = Tartrate-resistant acid phosphatase | TRAP+ cells seen in Hairy Cell Leukemia (B cells)
34
Richter Transformation
Transformation of chronic lymphocytic leukemia to diffuse large B-cell lymphoma, marked clinically by enlarging lymph node or spleen
35
Pautrier microabscesses definition and disease
Aggregates of neoplastic cells in epidermis, a skin rash that occurs in Mycosis Fungoides.
36
HTLV-1 Association
Adult T-cell leukemia/Lymphoma (ATLL) associated with HTLV-1 (human T-cell lymphoma-1) -rash, LA, HSM, lytic bone lesions and hypercalcemia
37
Red pulp enlargement association
Hairy cell leukemia
38
Sezary syndrome
occurs in mycosis fungoides when neoplastic mature CD4+ T cells have infiltrated skin and spread to blood. Characteristic lymphocytes with cerebriform nuclei are seen on blood smear (sezary cells).
39
H. Pylori Gastritis association
Marginal Zone Lymphoma
40
Maltoma
Marginal zone lymphoma in mucosal sites, subtype of marginal zone lymphoma
41
"Owl-eyed nuclei"
Large B cells with multilobed nuclei and prominent nuclei, CD15 and CD30 positive, called Reed Sternberg cells and seen in Hodgkin Lymphoma
42
Reed Sternberg Cells
"Owl-eye nuclei" Large B cells with multilobed nuclei and prominent nuclei, CD15 and CD30 positive, called Reed Sternberg cells and seen in Hodgkin Lymphoma
43
High IL-6 Association
Multiple myeloma (stimulates plasma cell growth and immunoglobulin production)
44
"punched-out" skeletal lesions
Multiple myeloma; lytic punched out skeletal lesions seen due to neoplastic plasma cells activating the RANK receptor on osteoclasts, leading to bone destruction. Note: Also seen in Adult T cell leukemia/lymphoma, BUT WITH RASH!
45
AML Cell Surface Markers
CD13, CD33, glycophorin M6 and platelet antigens M7
46
AML Subtype Mo
minimally differentiated
47
AML Subtype M1
myeloblastic, minimal maturation
48
AML Subtype M2
myeloblastic, granulocytic maturation - t(8;21)
49
AML Subtype M3
Acute Promyelocytic leukemia t(15;17)
50
AML Subtype M4
acute myelomonocytic leukemia - inv(16) - eosinophillic
51
AML Subtype M5
acute monocytic leukemia - del(11q), t(9;11), t(11;19) - proliferation of monoblasts, lack MPO, infiltrate gums
52
AML Subtype M6
Acute erythroid leukemia - have features of RBC's, PAS+
53
AML Subtype M7
Acute megakaryoblastic leukemia - t(1;22) - proliferation of megakaryoblasts, lack MPO, assoc. w downsyndrome (arrises before age 5)

Hem/Onc (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions