Surface markers

Question 1

CD2

Answer 1

1) T cell adhesion molecule (LFA2).

2) NK cells

Question 2

CD3

Answer 2

Signal transduction with TCR

Question 3

CD8

Answer 3

CTLs for binding MHC Class 1

Question 4

CD14

Answer 4

Macrophage LPS receptoe

Question 5

CD16

Answer 5

NK, Macrophage, and Neutrophils for opsonization via ADCC

Question 6

CD18

Answer 6

Leukocyte adhesion molecule (mutated in leukocyte adhesion deficiency)

Question 7

CD19

Answer 7

Not on plasma cells. B cell coreceptor with CD21 for activation

Question 8

CD20

Answer 8

Most B cells

Question 9

CD21

Answer 9

Mature B cells only.

1) Coreceptor with CD19
2) Receptor for EBV
3) Binds C3d (which enhances B cell response).

Question 10

CD25

Answer 10

Thelper cells and T regs have CD25 as alpha chain of IL-2 receptor

Question 11

CD28

Answer 11

T cell costimulatory molecule for B7 on APCs.

Question 12

CD34

Answer 12

HSC, used for adhesion.

Question 13

CD40

Answer 13

B cells use to bind CD40L on T cells.

Question 14

CD56

Answer 14

Nk Cells

Question 15

CD152

Answer 15

CTLA-4 on Activated T cells. Completes with CD28 for B7 binding.

CTLA4 and CD28 are both present on T cells.

Question 16

CTL markers

Effector mechanisms

Answer 16

CD2 (LFA2 T cell and NK cell adhesion molecule)
CD3 (signal transduction with TCR)
CD8 (coreceptor with MHC)
TCR (binds antigens)

Kills with perforin, granzymes, cytokines (TNF-B, IFN-y)

Question 17

NK cell markers

Effector mechanisms

Answer 17

CD2 (LFA2 T cell and NK cell adhesion molecule)
CD16 (Present on NK, Neutrophil and macrophage for opsonization and ADCC)
CD56 (NK cell specific adhesion molecule)

Kills with perforin, granzymes, cytokines (TNF-B, IFN-y)

Question 18

Macrophage markers

Effector mechanisms

Answer 18

CD14 and CD16

TNFa, enzymes, NO, O2 radicals