Suppositories Calc Lectures

Question 1

What are three calculations that may be necessary?

Answer 1

Pre-calibration of the mold
Density factor (displacement value)
Double casting

Question 2

Displacement of base as a function of density?

Answer 2

Same density as the base, it will displace an equivalent weight of the base
If its greater or small than the base, it will displace a proporptional weight of the base

Question 3

Define density factor

Answer 3

Used to determine how much of a base will be displaced by a drug

Question 4

Density factor equals?

Answer 4

Weight of drug divided by weight of drug displaced

Question 5

Double casting method?

Answer 5

Mix all of the drug with a portion of the base and use the mixture to partially fill each of the suppository mold cavities
Use plain base to overfill each cavity
Let cool, then remove excess base from top of mold
Remove suppositories, remelt and recast to evenly distribute the drug