SUPERFICIAL FUNGAL INFECTIONS Flashcards

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1
Q

Outline the 3 genera of Dermatophytic fungi causing tinea infections

A

Trichophyton
Microsporum
Epidermophyton

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2
Q

Why are dermatophtes restricted to the non viable skin?

A

because most are unable to grow at 37°C

or in the presence of sebum.

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3
Q

Which dermatophtes affects the hair?

A

Trichophyton and Microsporum

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4
Q

Which dermatophtes affects the nails?

A

Trichophyton and Epidermophyton

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5
Q

The inflammation caused by Dermatophytes is due to what?

A

Due to metabolic products of the fungus or to delayed hypersensitivity

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6
Q

How are ringworm infections transmitted?

A

by DIRECT CONTACT with materials (e.g. infected scales, hairs), animals, or soils

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7
Q

Classify Dermatophytes according to habitat

A

Zoophilic
Anthropophilic
Geophilic
Personal items e.g FOMITES

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8
Q

Outline the anthropophilic species

A
T. rubrum
T. tonsurans
T. violaceum
T. schoenleinii
M. Aoudouinii
M. Ferrugineum
Epidermophyton floccosum
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9
Q

Outline the zoophilic species

A

T. Mentagrophytea
T. Equinum
M. Canis

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10
Q

Outline the Geophilic specie

A

Microsporum gypseum

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11
Q

Dermatophyte have a worldwide distribution and reproduce asexually (T/F)

A

False.
Although they have a worldwide distribution, they reproduce sexually producing ASCOSPORE hence belong to the genus ARTHRODERMA

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12
Q

Tinea infections occur only in susceptible individuals (T/F)

A

True

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13
Q

Most dermatophytes initiate disease by their invasion of dead keratin with their branching, septate hyphae. (T/F)

A

False

It’s ALL Dermatophytes

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14
Q

Itemize 3 exogenous keratolytic enzymes produced by dermatophytes

A

Acid proteinases
elastase
keratinases

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15
Q

What is known as a Dermatophytid or Trichophytid?

A

A hypersensitivity reaction to a very active fungal infection due to the fungi itself or it’s products

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16
Q

What predisposes the host to chronic or recurrent dermatophyte infection?

A

the LACK OF OR A DEFECTIVE cell-mediated immunity/delayed hypersensitivity /inflamtory response

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17
Q

Describe in details what you expect to see on a KOH MOUNT preparation of a tinea infection

A

translucent branching, rod-shaped filaments (hyphae) of uniform width with lines of separation (septa) spanning the width and appearing at irregular intervals.

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18
Q

If the infection was actually due to candida what would you expect to see on KOH MOUNT preparation?

A

Elongated yeast forms(pseudohyphae) without true septations

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19
Q

What other investigations would you use to confirm the diagnosis of a tinea infection?

A

CULTURE

WOOD’S LIGHT EXAMINATION

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20
Q

Why is it important to do a culture? And name 2 types of agar used?

A

It’s used to identify the species of dermatophytes.
Mycosel agar
Sabouraud agar

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21
Q

All of the dermatophytes capable of invading hair will induce fluorescence (T/F)

A

False

Its only some

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22
Q

Mention the genus of Dermatophytes capable of being identified under Wood’s light?

A

Microsporum

Trichophyton

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23
Q

What colour do Microsporum and T. schoenleinni appear on wood’s light?

A

Microsporum - GREENISH YELLOW

T. schoenleinii - PALER GREEN

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24
Q

The wood’s light is an essential tool in the management of the patients in areas where favus infections are prevalent

A

True

And Microsporum too

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25
Q

Which zoophilic Dermatophypte commonly causes Tinea capitis?

A

Microsporum canis

Commonly found in cats and dogs

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26
Q

Itemize 3 factors that predispose children to Tinea capitis

A

Poor hygeine
Prolonged moist skin
Minor skin or scalp trauma

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27
Q

Which of the tinea infections may be seen as an epidemic

A

Tinea capitis

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28
Q

Ringworm infection of the body, trunk or extremities is called? And is commonly caused by what genus?

A

Tinea corporis

Trichophyton

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29
Q

Fungal infection of the feet/athlete’s foot is k no own as what? And what genus commonly causes this?

A

Tinea pedis
Epidermophyton floccosum
Trichophyton sp

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30
Q

What factors predispose individuals to Tinea pedis

A

Poor hygiene

Prolonged wearing of tennis shoes

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31
Q

Ringworm infections around the bearded area is know as

A

Tinea barbae

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32
Q

Ringworm infection of the face but not including infection of the bearded area is know as

A

Tinea faciei

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33
Q

Ringworm infection of the nail bed is known as? It’s otherwise called? What organism causes it?

A

Tinea unguium
Onychomycosis
Trichophyton spp

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34
Q

What age group are more predisposed to Tinea capitis

A

children between 3-7 years of age

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35
Q

What clinical signs accompany tinea capitis?

A

cervical or occipital lymphoadenopathy

alopecia

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36
Q

Itemize 5 clinical types of tinea capitis

A
Non-inflammatory black dot pattern
Inflammatory tinea capitis(KERION)
Seborrhoeic dermatitis like (GREY PATCH TYPE) 
Pustular type
Favus
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37
Q

One or multiple inflamed boggy red tender areas of alopecia with pustules on and/or in surrounding skin.

A

KERION(honey-comb)

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38
Q

Mowed wheat field appearance of the scalp

A

Seborrhoeic dermatitis like(GREY PATCHY TYPE)

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39
Q

Extensive hair loss with atrophy, scarring and so called scutula

A

FAVUS

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40
Q

What does SCUTULA mean?

A

Yellow adherent crusts present on the scalp

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41
Q

What genus is commonly isolated from the “grey patch” type of tinea capitis

A

Microsporum canis

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42
Q

What genus is commonly isolated from the “black-dot” variant of tinea capitis?

A

Trichophyton tonsurans

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43
Q

What clinical type of tinea capitis results in SCARRING ALOPECIA if not treated promptly?

A

Inflammatory tinea capitis(KERION)
FAVUS
The rest can cause non-scarring alooecia

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44
Q

What clinical type of tinea capitis occurs without scaling or significant hair loss.

A

PUSTULAR TYPE

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45
Q

What investigations would you want to do in a suspected case of Tinea capitis?

A

WOOD’S LIGHTexamination of Plucked hair
DIRECT MICROSCOPY in 10% KOH WET MOUNTof scales and hair
CULTURE in sabouraud dextrose agar/mycosel agar

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46
Q

What component of sabouraud dextrose agar/mycosel agar suppress saprophyte and bacterial growth?

A

cycloheximide and chloramphenicol

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47
Q

Treatment options for Tinea capitis is not always systemic. (T/F)

A

False

It’s always systemic!

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48
Q

Outline the treatment options of tinea capitis?

A

GRISEOFULVIN
15-25 mg/kg/day for 2 months

FLUCONAZOLE (Diflucan)
8 mg/kg once weekly for 4-16 weeks.

TERBINAFINE(Lamisil)
20-40 kg body weight: 125 mg daily 2-4 weeks >40 kg body weight: 250 mg daily 2-4 weeks.

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49
Q

Outline 3 side effects of Griseofulvin

A

Headache
GI upset
Photosensitivity
It is well absorbed after fatty meal.

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50
Q

What differentiates tinea barbae and Tinea capitis from bacteria Folliculitis clinically?

A

Like tinea capitis, the hairs are always infected and easily removed while The hair in bacterial folliculitis resist removal (or painful on removal).

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51
Q

What are the primary lesions seen in tinea barbae?

A

Follicular PAPULES
PUSTLES
NODULES

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52
Q

What are the secondary lesions seen in tinea barbae?

A

KERION

CRUSTS

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53
Q

What is tinea barbae commonly mistaken for?

A

Staph Aureus folliculitis

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54
Q

Tinea facialis is otherwise known as?

A

Epidermal dermatophytosis

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55
Q

Are tinea barbae lesions painful or painless?

A

Painful

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56
Q

What is the treatment for tinea barbae?

A

Same as tinea capitis!

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57
Q

Tinea corporis affects glaborous and non glaborous areas of the skin (T/F)

A

False

Affects glaborous areas only

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58
Q

What other tinea presentations have been found to accompany tinea corporis?

A

Tinea manuum

Tinea pedis

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59
Q

What is the most common organism causing Tinea corporis and dermatophytosis world wide?

A

Trichophyton rubrum

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60
Q

What are the anthropophilic species causing tinea corporis

A

Trichophyton rubrum

Epidermophyton floccosum

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61
Q

What are the zoophilic specie causing tinea corporis

A

Microsporum canis

Trichophyton mentagrophyte

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62
Q

What is the extremely rare geographic specie causing tinea corporis

A

Microsporum gypseum

63
Q

What is known as tinea corporis gladiatorum?

A

Tinea corporis due to Skin-to-skin contact among young children and older children participating in sports

64
Q

What is the classic presentation of tinea corporis?

A

it’s the subacute onset of a single (or few) well demarcated annular erythematous pruritic plaque(s) with a raised border and central clearing

65
Q

What are the primary lesions seen in the border

A

papular
vesicular
pustular

66
Q

What are polycyclic patterns? Under what condition can a patient present in this manner? How does this correlate with treatment?

A

Extensive and sever presentations characterized by multiple plaques which coalesce often into unusual paterns
Underlying immunodeficiency
Difficult to treat with topical therapy alone

67
Q

Outline the characteristic symptoms of tinea corporis?

A
"SPECC"
Scaling
Pruritus
Erythema
Central clearing 
Concentric rings
68
Q

What is tinea incognito

A

It’s a cortisone(OTC TOPICAL corticosteroid therapy) induced alteration in the characteristic morphological features or classic presentation of tinea infections

69
Q

What other medication has been implicated in tinea incognito?

A

topical calcineurin inhibitors (pimecrolimus )

70
Q

What are the features of tinea incognito?

A

Thinned skin
Reduce inflammation
Cortisone induced morphological changes
Altered morphology, well defined border may be absent
Groin, face, dorsum of the hand affectation

71
Q

Fungal infections of the skin show characteristic fluorescence on wood’s light (T/F)

A

False

Fungal infections of the SKIN do not flouresce

72
Q

What investigations would you want to do in a suspected case of tinea corporis?

A

Obtain Skin scrapings from the edge of the lesion
Direct microscopy
culture

73
Q

What are the treatment options for a confirmed case of tinea corporis?

A

TOPICAL ANTIFUNGALS
whitfield’s ointment
imidazole cream e.g. canestin

GRISEOFULVIN
10-15mg/kg/day in children

FLUCONAZOLE
150mg/wk 2-4wks

ITRACONAZOLE
100mg qd 2wks

TERBINAFINE
250mg /day 1-2wks

74
Q

What population group is Tinea cruris more commonly found?

A

Commonly seen in MEN

It’s rare in children

75
Q

What is the classic presentation of Tinea cruris?

A

A half moon shaped red brown plaque often pruritic which forms as a well-defined scaling, and sometimes a vesicular border, advances out of the crural fold onto the thigh.

76
Q

Mention 4 ways by which tinea cruris can be differentiated from candida infection of the groin clinically?

A
CANDIDA INFECTIONS
Scrotal involvement is common
Bilateral involvements is common
Typical fringe of scales at the border
Satellite papules and pustules seen
77
Q

Griseofulvin is routinely used in the treatment of tinea cruris (T/F)

A

False!

78
Q

What are the treatment options for a confirmed case of tinea cruris?

A
TOPICAL
Terbinafine 1% cream (Fungicidal, Lamisil) applied twice daily for 1 week.
ORAL
Fluconazole 
150 mg once weekly for 2-4 weeks.
Itraconazole 
100 mg twice daily for 1 week.
Terbinafine
250mg once daily for 1-2 weeks.
79
Q

What is the most common type of fungal infection in humans?

A

Tinea pedis(Athlete’s foot)

80
Q

Itemize the 3 organisms implicated in causing tinea pedis?

A

Trichophyton rubrum
Trichophyton mentagrophytes
Epidermophyton floccosum

81
Q

What is the most common and most stubborn organism causing tinea pedis

A

Trichophyton rubrum

82
Q

Mention 3 factors that promote relapse in tinea pedis infection

A

sharing of wash places e.g. in showers swimming pools

tight foot wears

83
Q

How does tinea pedis present clinically?

A

Classical ringworm infection
Interdigital tinea pedis (toe web infection)
Chronic scaly infection of the planter surface (hyperkeratotic or moccasin type of tinea pedis)
Acute vesicular tinea pedis

84
Q

The classic ringworm pattern of tinea pedis is restricted to just the Dorsum of the foot (T/F)

A

False

It can appear on any body surface

85
Q

Where is the most common site for interdigital tinea pedis?

A

The 4th toe web

86
Q

The moccasin type of tinea pedis commonly affects what body area?

A

The entire sole i.e PLANTAR SURFACE

87
Q

The hyperkeratotic type of tinea pedis is usually restricted to just the soles of the feet (T/F)

A

False

The hands may also be infected

88
Q

It is common to see both palms and soles infected simultaneously in hyperkeratotic type Tinea pedis infection (T/F)

A

False

It’s rare

89
Q

What is the usual pattern of moccasin type tinea pedis infection?

A

The pattern is infection of two feet and one hand or of two hands and one foot.

90
Q

What is the usual pathogen causing chronic scaly infection of the plantar surface?

A

Trichophyton rubrum

91
Q

Which clinical sub-type of tinea pedis is associated with a dermatophytid or Id rxn?

A

It’s the acute vesicular tinea pedis otherwise called Bullous sub-type

92
Q

Mr A presented with vesicular eruptions which appeared fused into bullae. Few days later a second wave of vesicles followed shortly in the same area and at distant sites such as his arm, chest, and along the sides of the fingers. He complained that they were really itchy. What would you expect to see on KOH mount prep obtained from the roof of these new itchy vesicles?

A

NOTHING!
These itchy sterile vesicles represent an allergic response to the fungus and are termed dermatophytid or id reaction.
They subside when the infection is controlled.

93
Q

Outline the primary lesions seen in Bullous sub type of tinea pedis

A

VESSICLES

BULLAE

94
Q

Outline the secondary lesions seen in Bullous sub type of tinea pedis

A

ERYTHEMA
FINES SCALES
EROSIONS
seen on plantar surface of foot

95
Q

How would you counsel a patient who has athlete’s foot?

A

Keep the space in-between the toes DRY and expose to air
wear cotton socks
Do not wear shoes that are too tight or hot.
Change socks daily as this will help prevent re-infection.

96
Q

What are the treatment options for a diagnosed case of athlete’s foot?

A

TOPICAL
Imidazole cream or Whitfield’s ointment twice daily until a week after symptoms have cleared. This usually takes a minimum of 4 weeks

ORAL
Griseofulvin
5-7mg/kg/day 6-12wks
Fluconazole
500mg once a wk for 3-4wks
97
Q

Tinea unguium is otherwise called

A

Onychomycosis

98
Q

Finger nails are more commonly affected than toe nails in tinea unguim(T/F)

A

False

Toe nails are more affected

99
Q

Tinea unguium is usually associated with what?

A

Tinea pedis

100
Q

Initial lesions of tinea unguium occur at the proximal end of the nail(T/F)

A

False

Begins at the distal end/free edge and spreads proximally

101
Q

Itemize 4 nail changes seen in onychomycosis?

A
Subungual hyperkeratosis
Onycholysis
Nail ridges/furrows
Brown or yellowish nail discolouration 
Lack of nail lustre and friability
102
Q

Fingernail lesions are usually accompanied with what?

A

with a chronic Trichophyton rubrum infection of the skin of the hands.

103
Q

Mention 2 investigations to be done in a patient with tinea unguium?

A

SCRAPING of subungual keratinized debris

NAIL CLIPPINGS for direct microscopy and culture

104
Q

Mention 3 treatment options for onychomycosis?

A

Thickened toenails softened using Whitfield’s ointment and then thinned with a file

griseofulvin 1g daily until the affected nails have grown out completely

Nail extraction under local anaesthetics and adequate griseofulvin cover

105
Q

How long should Griseofulvin be used for finger nails?

A

6-8 months

106
Q

How long should Griseofulvin be used for toe nails?

A

12-16 months

107
Q

Recurrence rarely occurs in tinea unguium infection (T/F)?

A

False

Recurrence is common

108
Q

Tinea of the Dorsum of the hand has the appearance of dry, diffuse keratolytic form of Tinea on the soles (T/F)?

A

False

It’s Tinea of the palm!

109
Q

Tinea of the dorsum of the hand has all the features of Tinea corporis (T/F)?

A

True

110
Q

Tinea manuum is frequently in association with Tinea pedis

A

True

111
Q

Treatment is the same as for Tinea unguium and recurrence is common (T/F)?

A

False

Treatment is the same as for Tinea pedis

112
Q

Mention 3 species of organisms causing Ptyriasis vesicolor?

A

Malassezia furfur
Malassezia restricta
Malassezia globosa

113
Q

Ptyriasis vesicolor may be caused by a Dermatophytic organism (T/F)?

A

False!

114
Q

Ptyriasis vesicolor may sometimes be infectious (T/F)?

A

False

It’s non-infectious

115
Q

What substance is released by the organism causing Ptyriasis vesicolor and how does it mediate it’s actions?

A

Azelaic acid

a competitive inhibitor of tyrosinase which inhibit the increase in pigment production by melanocytes

116
Q

The yeast form of malassezia is implicated in the pathogenesis of Ptyriasis vesicolor (T/F)?

A

False!

It’s the mycelia form(malassezia) not yeast(ptyrosporum)

117
Q

Itemize 5 predisposing factors to pityriasis veraicolor?

A
Heat
Moisture
Working in hot humid factories and occlusion of skin
Corticosteroid Creams (habitual use)
Immunosuppressive therapy
Malnutrition
Chronic debilitating pulmonary tuberculosis
Cushing’s syndrome
118
Q

What are the commonly affected areas in pityriasis vesicolor?

A

Face
Neck and Shoulders
Chest
Upper back

119
Q

Itemize 2 important investigations in the diagnosis of Pityriasis vesicolor?

A

DIRECT MICROSCOPY of skin scrapings examined in 10-30% KOH wet mount with slide stained with 1% methylene blue

WOOD’S LIGHT EXAMINATION

120
Q

What characteristics appearance is seen on KOH mount of pityriasis vesicolor?

A

short branched hyphae and spots (characteristic spaghetti and meat balls appearance)

121
Q

How does pityriasis vesicolor appear on Wood’s light examination?

A

yellow to white fluorescence

122
Q

Itemize 5 treatment options for pityriasis vesicolor?

A
Imidazole cream. (2-4 wks)
Selenium sulphide bath  (daily for 3wks)
Itraconazole      (200mg/day for 7 days) for stubborn and widespread infections
Fluconazole   (300/400mg single dose)
Ketoconazole  (300mg single dose)

Patient should be informed that after treatment it takes some time for the skin color to return to normal. Sunlight accelerates repigmentation.

123
Q

What is the most common organism causing candidiasis?

A

Candida albicans

124
Q

The organism causing candidiasis is a recognized commensals of the human GIT (T/F)?

A

True

125
Q

Itemize 6 predisposing factors to candidiasis?

A
Malnutrition
Pregnancy
Diabetes mellitus
obesity
Immunosuppressive therapy e.g cytotoxic drugs
Hot humid climates
126
Q

Candida albicans becomes pathogenic under what conditions?

A

pregnancy
DM
corticosteroid therapy
long term antibiotic therapy

127
Q

What is the Primary lesion in candidiasis?

A

Pustule

128
Q

Mention the 3 types of candidiasis?

A

Oral candidiasis
Chronic paronychia
Genital candidiasis

129
Q

In oral candidiasis the angle of the mouth is mostly affected (T/F)?

A

False!

It’s the Tongue that’s affected most

130
Q

Oral candidiasis can be gotten during birth in infants (T/F)?

A

True

131
Q

Genital candidiasis may be the first manifestation of HIV (T/F)?

A

False

It’s oropharyngeal candidiasis

132
Q

A recently identified yeast mostly identified in HIV patients is known as?

A

Candida dubliniensis

133
Q

What type of candidiasis also occurs in people with advanced stage cancer.

A

Oral candidiasis

The two most common species are C. albicans and C. glabrata

134
Q

What are the clinical features of oral candidiasis?

A

Whitish adherent patches (not easily removed) on an erythematous base
Angular stomatitis (peleche)
Red sores under dentures (denture sore mouth)
Long standing – hyperplasia and thickening of mucosa

135
Q

Mention 4 areas commonly affected in candida intertrigo?

A

groin
gluteal fold
under pendulous breast
interdigital clefts

136
Q

What are the xteristic lesions in candida intertrigo called?

A

Satellite lesions(papules)

137
Q

Poor hygiene is a known risk factor for intertrigous candidiasis (T/F)?

A

True

138
Q

Chronic paronychia is mostly bacterial (T/F)?

A

False

It’s Acute paronychia

139
Q

Candida paronychia usually presents as a Painless swelling around the nail (T/F)?

A

False

It’s painful

140
Q

Expression of greenish pus in chronic paronychia suggest what infection?

A

PSEUDOMAONAS

141
Q

Chronic paronychia is common in what group of people?

A

Wet workers e.g Dish washers

Finger sucking

142
Q

Candida vulvovaginitis is not sexually transmitted (T/F)?

A

False

Could be sexually transmitted

143
Q

A 35y/o woman complains of vaginal Itching and Creamy white, thick, scanty vaginal discharge. On examination a Swollen red labia with areas of maceration and erosion was seen with spread to the thighs and anus with discrete pustules around the edges of the lesion.
What’s the most likely diagnosis?
What are these discrete lesions called?

A

Candida vulvovaginitis

Satellite lesions

144
Q

Itemize 4 predisposing factors to candidia vulvovaginitis?

A

use of broad spectrum antibiotics
pregnancy
low vaginal pH and
diabetes mellitus

145
Q

Candida vulvovaginitis is a slightly uncommon condition in women (T/F)

A

False

It’s common

146
Q

Candida balanitis affects only uncircumcised penis (T/F)?

A

False

Can affect circumcised penis also

147
Q

Candida balanitis is gotten mainly due to poor hygiene (T/F)?

A

False

Sexual intercourse with an infected female

148
Q

A 25y/o man presents with Tender, red papules and pustules on the shaft and glans of his penis giving a pink circinate appearance. History is positive for unprotected sexual intercourse and there was also associated whitish discharge
What’s the most likely diagnosis?
What treatment options can be offered to this patient?

A

Candida balanitis

Application of fluconazole or clotrimazole bd for 7 days

149
Q

What are the components of chronic mucocutaneous candidiasis syndrome?

A

recurrent, persistent candidiasis of the skin, nails, and mucous membrane without disseminated candidiasis

150
Q

chronic mucocutaneous candidiasis syndrome is first recognized in what group of individuals?

A

Infants

151
Q

Mention 2 endocrine disorders associated with chronic mucocutaneous candidiasis?

A

hyperparathyroidism

Addison’s disease

152
Q

Mention 3 important investigations in the morning of chronic mucocutaneous candidiasis

A

KOH wet mount
Swabs from suspected areas should be sent for culture.
The urine should always be tested for sugar.
A detailed CMI (cell mediated immunity) work up should be done

153
Q

What are the treatment modalities for chronic mucocutaneous candidiasis?

A
Keep affected area dry
potassium permanganate solution
Any of the imidazole creams or powder
Vaginal tablets (pessaries)
Griseofulvine
Recurrent CMC can be treated with ketoconazole
Treat the underlying cause
154
Q

What drug is used in the treatment of recurrent chronic mucocutaneous candidiasis

A

Ketoconazole