Summer Final Exam Flashcards
Highest Occurence of recall
General surgery
Diagnostic criteria for PTSD
Both: a)person witnessed, experienced or was confronted with an event or events that involved actual or threatened death or serious injury or threat to physical integrity of self or others b) the person’s response involved intense fear, helplessness or horror
Of 26 patients with awareness in study ___ had no post-op sequelae
8
Percent of recall due to faulty anesthetic technique
70%
Percent of recall due to failure to check equipment
20%
Goals of satisfactory anesthetic
1) Adequate perfusion of all organ systems 2) unresponsive to noxious stimuli 3)no awareness or recall of events during procedure
Cortical Phenomenon
Consciousness (controlled by hypnotics)
Poor indicators of consciousness
Subcortical phenomenon: movement (cord reflex), hemodynamic response (brain stem)
Depth of anesthesia can be defined
by suppression of clinically relevant responses to noxious stimuli
Analgesic
Agent that relieves pain w/o loss of consciousness
Amnestic
agent that results in loss of memory of an event or time period
Hypnotic
an agent that produces drowsiness and acts to induce sleep or sleep like state
Sedative
an agent that allays excitement and produces a calm state
Muscle relaxant
an agent which blocks the transmission of nervous impulses to skeletal muscle, rendering patient paralyzed and unable to breathe or move
Tranquilizer
agent that quiets or calms patient w/o affecting clarity of consciousness
Anxiolytic
agent that relieves apprehension and fear, relief from anxiety
Most commonly used measurements for monitoring anesthetic depth
HR and BP
Explicit Knowledge
easily recalled and explained
Implicit knowledge
cannot consciously recall, influences our behavior
Tracheal intubation is about ___ as stimulating as skin inscision
twice
Most anesthesiologists rely on ___ to assess anesthetic depth
their clinical experience and the dose of anesthetic
Isolated arm method
Blood pressure cuff inflated high, patient is relaxed and anesthetized. Patient is told to squeeze. Some patients respond even though all other signs would indicate anesthetic depth
MAC that we typically use
ED50
Doses minimally larger than ED50
prevent movement
concentration response relation for inhaled anesthetics is steep
So, ED95 differed minimally from ED50
MAC is mediated at subcortical levels so..
Because the cortex is more sensitive MAC is at a higher concentration than is really needed. The concentration of anesthetic needed to cause unconsciousness is much lower
Factors that increase mac
Hyperthermia, hyperthyroidism, alcoholism, acute administration of dextroamphetamine, young age
No effect on MAC
duration of anesthesia, sex, metabolic acid-base status, hyper/hypocapnia, isovolemic anemia, HTN
Redheads require ___ more anesthesia on average than brunettes
20%
Work practices
Vigilance, fatigue management, seeking advice
For the intraoperative phase
Scan equipment regularly during each case, take care to avoid wrong drug admin., give adequate hypnotic drug where possible, minimize use of muscle relaxants, respond rapidly to suspected inadequate anesthesia, modulate OR behavior, consider using EEG based monitor
BIS
Bispectral Index system
Differential amplifier measures potential difference between electrodes 2 and 3. Electrode 1 is the ground (reference). Electrode 4 is used in noise reduction.
EEG
represents cortical electrical activity, continuous, responsive, noninvasive indicator of cerebral fxn
BIS XP
sensor with additional electrode (#4), electrosurgery resistant, enhanced detection of near suppression
Density Spectral Array (DSA)
graphical representation of EEG frequency differences between the 2 hemispheres
Derivation of BIS
30, 1 second epochs of frontal EEG, empirical technique is statistical multivariate regression, uses Entropy
Burst suppression ratio
extent of electrical silence (0 active 100 silent)
Relative alpha/beta ratio
8-13 Hz energy/ 13-30 Hz energy
Bicoherence of EEG
degree of phase coupling between individual waves
BIS range
0 to 100. 0 is unconscious, 100 is fully awake
SQI (signal quality index)
ranges from 0-100%. This is the % of good epochs in the last 60 that could be used for calculation of the BIS.
EMG
electrical power in the 70-110 Hz range (given in dB with trend and bar graph)
SR (suppression ratio)
% of epochs in past 63 seconds in which EEG signal is considered suppressed
SEF (Spectral edge frequency)
the frequency at which 95% of total power lies below and 5% lies above
BIS responds more ___ to an emergence than spectral edge frequency
rapidly
EMG signals
tend to increase BIS number artifactually
Hypothermia and ischemia
appear identical to deep sedation and decrease BIS number
BIS responds better to
Halogenated agents and propofol than to N2O and Ketamine
Prevention of implicit memory at BIS of
84-91
Awareness estimate
0.2-0.4% for elective and emergency surgery
BIS does NOT
predict movement or hemodynamic response
BIS index is designed
to measure the effect of hypnotic anesthetic drugs.
When patients move during surgery with a BIS below 60,
additional analgesia may suppress further movement
In BIS movement trials,
Small opioid doses DID blunt surgical responses, and large hypnotic doses DID NOT eliminate surgical responses
Hypothesis from BIS movement trials
Movement/autonomic responses correlate with analgesia and EEG changes correlate with hypnosis/consciousness
BIS must be used
in conjunction with traditional vital sign monitoring
Entropy
describes irregularity, complexity or unpredictability characteristics of a signal
When the patient is awake,
EEG is highly irregular and the amt of entropy is very high. As the pt goes into deeper planes of anesthesia, EEG will have a more regular pattern of wave forms which brings down entropy
State Entropy
cortical, steady and robust
Response Entropy
muscle, fast reacting
PSI
Patient State Index. 25-50 optimal hypnotic state for general anesthesia
Entropy range of 40-60
Clinically meaningful anesthesia with low probability of consciousness
For control-a-flo: Maintain vertical distance of ___ or greater from container fluid level to venipuncture device
75 cm (30”)
Infusion pump types
Peristaltic (rotary or linear), cassette, elastomeric reservoir, syringe
Cerulean blue clamp pump (linear peristaltic?)
+/- 5% accuracy
Bard Infus O.R.
Infusion: linear rate +/- 3% accuracy, Bolus: linear displacement +/-3%