Summary of influence of substituents on electrophilic substitution Flashcards
1
Q
NH2
A
v v activating
o/p directing
polysubstitution usual
2
Q
NR2
A
v v activating
o/p directing
polysubstitution usual
3
Q
OH
A
v activating
o/p directing
polysubstitution usual
4
Q
OR
A
v activating
o/p directing
polysubstitution usual
5
Q
NHCOR
A
activating
o/p directing
monosubstitution possible
6
Q
OCOR
A
activating
o/p directing
monosubstitution possible
7
Q
Ph (or Ar)
A
weakly activating
o/p directing
monosubstitution possible
8
Q
CH3 (or R)
A
weakly activating
o/p directing
monosubstitution possible
9
Q
H
A
standard case
orientation not applicable
mono substitution usual
10
Q
I
A
weakly deactivating
o/p directing
11
Q
Br
A
weakly deactivating
o/p directing
12
Q
Cl
A
weakly deactivating
o/p directing
13
Q
F
A
weakly deactivating
o/p directing
14
Q
CO2R
A
deactivating
m directing
15
Q
CO2H
A
deactivating
m directing
