Important functional group interconversions in aromatic systems Flashcards
1
Q
from NH2 –> F
A
i) HNO2 ii) BF4- / /\ (heat)
2
Q
from NH2 –> Cl
A
i) HNO2 ii) Cu2Cl2
Sandmeyer reaction
3
Q
from NH2 –> Br
A
i) HNO2 ii) Cu2Br2
Sandmeyer reaction
4
Q
from NH2 –> I
A
i) HNO2 ii) KI
5
Q
from CN –> Br
A
i) HNO2 ii) Cu2(CN)2
6
Q
from NH2 –> SR
A
i) HNO2 ii) NaSR
7
Q
from NH2 –> OH
A
i) HNO2 ii) H2O / /\ (heat)
8
Q
from NH2 –> N3
A
i) HNO2 ii) NaN3
9
Q
from NH2 –> NO2
A
- i) HNO2 ii) NaNO2
- CF3CO3H
oxidation
10
Q
from NH2 –> H
A
i) HNO2 ii) H3PO2
technically FGA/FGR
11
Q
from SO3H –> H
A
steam; or H20 / /\ (heat)
technically FGA/FGR
12
Q
from NO2 –> NH2
A
- Sn/ HCl; or H2/ Pd
reduces 2 or more groups - Na2S
reduces 1 of 2 groups
13
Q
from COCl –> CONR1R2
A
R1R2NH
technically C-N
14
Q
from COCl –> CO2R
A
ROH
technically C-O
15
Q
from CO2H –> CO2R
A
ROH / H+ / /\ (heat)
technically C-O
