Summary Flashcards
1
Q
Depression
A
Monoamine hypothesis: 5HT and NA
2
Q
Bipolar
A
5HT and NA
- lithium and mood stabilisers
3
Q
Schizophrenia
A
- Disturbed and hyperactive dopaminergic signal transduction
- DA D2 antagonist
4
Q
PD
A
- Loss of dopaminergic neurons in the SNpc
- Presence of lewy bodies (a-synuclein)
- Levadopa
5
Q
HD
A
> 36 trinucleotide repeats
- inclusion bodies
- tetrabenazine: chorea symptoms
6
Q
MND
A
- Genetic (recessive mutation)
- Excitotoxicity (loss of glial glutamate transporters -> excess glutamate)
- Oxidative stress (SOD-1 mutation)
- Riuzole: NMDA antagonist
7
Q
MS
A
- autoimmune demylinating disorder
- detection: MRI (detecting plaques in brain) and CSF (Increased igG and oligoclonal bands)
8
Q
AD
A
- Ameloid precursor protein: helps neuron grow/repair
- If bd with b-secretase -> insoluble -> ameloid beta -> sticks together -> beta ameloid plaques -> disrupt signalling and cause inflammation
- Neurofibrillary tangles inside neuron
- Cholinergic hypothesis: decrease in choline acetyltransferase (synthesis ACh)
- Treatment: achetylcholineserase inhibitors
9
Q
CTE
A
- Irregular depositions of hyperphosphorylated tau in superficial cortical layers at base of sulci and surrounding BVs
