Sulfonylureas and Meglitinides - Insulin Secretagogues Flashcards

1
Q

Sulfonylureas - Glipizide (Glucotrol), glyburide (Diabeta), glimepiride (Amaryl) MOA

A
  • stimulates an increase in secretion of insulin from beta cells
  • reduce glucose release from the liver
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2
Q

Sulfonylureas (Glucotrol, Diabeta, Amaryl) ADRs

A
  • Hypoglycemia
  • Weight gain
  • Agranulocytosis (rare)
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3
Q

Sulfonylureas Contraindications

A
  • Type 1 DM

- Sulfa allergy

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4
Q

Sulfonylureas (Glucotrol Diabeta, Amaryl) Pt education

A
  • take with food - if you skip a meal, skip dose
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5
Q

Megalitinides - Repaglinide (Prandin), nateglinide (Starlix) MOA “glinides”

A
  • increase insulin release from beta cells by closing potassium channels and opening calcium channels
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6
Q

Megalitinides ADRs

A
  • hypoglycemia
  • weight gain
  • URIs
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7
Q

Megalitinides (Prandin, Starlix) contraindications

A
  • Type 1 DM

- Avoid in pregnancy, lactation, and pediatrics

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8
Q

Megalitinides (prandin, starlix) patient education

A
  • take with food; no more than 30 minutes before a meal - hold if not eating
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