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pharm quiz 5 > Sulfonylureas > Flashcards

Sulfonylureas Flashcards

1
Q

3 second gen sulfonylureas
Guy Bride
Grizzly Guy
Gimme Gay Pride

A

Glyburide
Glibizide
Glimepiride

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2
Q

Major MOA

A

Increase insulin production from functioning beta cells

(via blocking potassium channels&raquo_space;> Inhibition causes depolarization of beta cell membrane, opening voltage gated Ca channels. Increased Ca influx stimulates insulin granule exocytosis)

*minor effect on increasing insulin sensitivity and decreasing hepatic glucose output(

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3
Q

Sulfonylureas lower A1C?

A

Yes - by 1-1.5%

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4
Q

Target patients for best response to sulfonylureas?

A

Newly diagnosed, high c-peptide

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5
Q

Safest 2nd gen sulfonylurea for patients with renal impairment?

A

Glipizide

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6
Q

Drug with highest incidence of hypoglycemia among 2nd gen sulfonylureas?

A

Glyburide

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7
Q

Common ADRs for sulfonylureas

A

Hypoglycemia

Weight gain

GI (N/V, Heartburn)

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8
Q

Contraindications

A

Elderly

DKA

Severe renal or liver disease

Hypoglycemia unawareness

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9
Q

Most preferred sulfonylureas?

A

Glipizide ER

Glimepiride

in combo w Metformin

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pharm quiz 5 (4 decks)

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