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Antimicrobial Drugs 3 - DNA synthesis inhibitors > Sulfonamides > Flashcards

Sulfonamides Flashcards

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Biology 101 flashcards
1
Q

Sulfonamides

A

sulfamethoxazole, sulfisoxazole, sulfadiazine

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2
Q

Mechanism

A

inhibit dihydropteorate synthase -> decrease hydrofolic acid in bacteria -> inhibit DNA synthesis

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3
Q

Drug interactions

A 
displaces other drugs from albumin (increases toxicity)
inhibits CYP (warfarin - vit K1 NOT given, need anticoagulation)
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4
Q

Adverse effects

A

skin rashes (stevens-johnson)
crystalluria
anemia

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5
Q

Use of sulfamethaoxazole/sulfisoxazole

A

Prevent or treat UTI

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6
Q

Use of Sulfisoxazole + erythromycin

A

otitis media (pediatrics)

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7
Q

Silver sulfadiazine ointment

A

burn patients/superficial skin infx

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8
Q

Contraindicated

A

Infants < 2 months, nursing or pregnant women
Causes kernicterus
OK in kids > 6 months

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Antimicrobial Drugs 3 - DNA synthesis inhibitors (3 decks)

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