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Antimicrobial Drugs 3 - DNA synthesis inhibitors > Fluoroquinolones > Flashcards

Fluoroquinolones Flashcards

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Biology 101 flashcards
1
Q

Fluoroquinolone drugs

A

Ciprofloxain, norofloxacin, levofloxacin

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2
Q

Mechanism

A

Inhibit DNA gyrase

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3
Q

Pharmacokinetics

A

chelate divalent and trivalent cations (do not give with dairy or antacids)
administered once a day

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4
Q

Drug interactions

A

Inhibits CYP (lots of caffeine -> seizures; inhibits warfarin metabolism)

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5
Q

Adverse reactions

A

CNS problems

Phototoxicity

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6
Q

Contraindicated

A

children under 18 years, pregnant or nursing women

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7
Q

Clinical uses

A

UTI and prostatitis (P. aeruginosa, Enterbacteriaceae)
Diarrhea & travelers diarrhea (shigella, camplobacter, salmonella, E. coli)
Sinusitis & bronchitis (pneumococci, H. influ)

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8
Q

Levofloxacin use

A

Community acquired pneumonia (cipro/noro NOT effective)

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Antimicrobial Drugs 3 - DNA synthesis inhibitors (3 decks)

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