substitution vs elimination Flashcards
strong acids should not appear in mechanisms under ____ conditions
basic
any acid whose pKa is < 0 will be a ____
strong acid
any base who’s conjugate acid has a pKa that is >14 will be a
strong base
why is there comp between E and Sn
because most nucleophiles can also act as bases
would it be Sn2 or E2 with a tertiary halogenoalkane
E2
what do we do if we have a secondary or primary halogenoalkane when deciding between Sn2 and E2
look at the strength of the nucleophile/base and the reaction temperature
reactions with strong nucleophiles prefer ___ (E2 or Sn2)
Sn2
what are 4 examples of strong nucleophiles
OH- , MeO- , NC-, I-
does a higher temperature prefer E2 or Sn2
E2 as the reaction rate increases more than in the Sn2
do strong bulky bases prefer E2 or Sn2
E2
does increasing the temp promote Sn1 or E1
E1
Sn2+E2 vs Sn1+E1 : a high concentration of a strong nucleophile/base will promote ___
Sn2+E2
we can assume a ____ concentration of attacking species is present unless it has been deliberately made dilute.
high
with good leaving groups ____
all reactions are feasible
with poor leaving groups ____
only Sn2+E2 reactions tend to be feasible.
better leaving groups tend to be ___
weaker bases
All the reaction do not occur unless the carbon atom bonded to the leaving group is ___
Sp3
Sn2+E2 vs Sn1+E1 : aprotic solvents tend to favour ____
2
Sn2+E2 vs Sn1+E1 : protic solvents tend to favour ____
1
what is an allyl carbon
a carbon which is next to a C=C.
If the leaving group is bonded to a primary allyl or benzyl carbon, then
both Sn2 and Sn1 reactions are feasible
alcohols can be converted to alkyl chlorides using ___ . what type of reaction is this?
SOCl2, Sn2 which happens twice
going down the halides does the leaving group ability increase or decrease?
increase
if we use ___ conditions, we can convert a poor leaving group into a good one
acidic
