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Essentials 1.3 Pharma-Explosion > Substance Use Disorders Drug List > Flashcards

Substance Use Disorders Drug List Flashcards

1
Q

Describe the MOA of Flumazenil

A

GABA-A/Benzodiazepine Antagonist

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2
Q

What is the indication for Flumazenil?

A

Overdose/Reversal of benzodiazepine ONLY in inpatient medical settings

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3
Q

How is Flumazenil administered?

A

IV

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4
Q

What is the Black Box Warning for Flumazenil?

A

Seizures

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5
Q

Describe the MOA of Disulfiram

A

Inhibits Aldehyde Dehydrogenase

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6
Q

How is Disulfiram administered?

A

Orally

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7
Q

Describe that clinical usage for Disulfiram

A

Aversion therapy allowing for relapse prevention/maintenance

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8
Q

What is the Black Box Warning for Disulfiram?

A

Should NEVER be used in the setting of alcohol intoxication or without full consent

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9
Q

Describe the clinical usage for Acamprosate

A

Relapse prevention/Maintenance

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10
Q

Describe the side effects of Acamprosate

A

GI & Diarrhea

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11
Q

Name 2 drugs used to treat alcohol withdrawal

A
  1. Chlordiazepoxide
  2. Diazepam
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12
Q

Describe the MOA of Chlordiazepoxide, Diazepam, & Lorazepam

A

GABA-A receptor agonists, increasing the frequency of Cl- channel opening

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13
Q

How are Chlordiazepoxide, Diazepam, & Lorazepam administered?

A

Orally, IM, & IV

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14
Q

What are the side effects associated with Chlordiazepoxide, Diazepam, & Lorazepam?

A

Increased risk of respiratory depression when combined with opioids

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15
Q

Describe the MOA of Phenobarbital

A

GABA-A receptor agonists, increasing the frequency of Cl- channel opening

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16
Q

How is Phenobarbital administered?

A

Orally, IM, & IV

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17
Q

Describe the MOA of Naloxone

A

Mu-Opioid Receptor Antagonist

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18
Q

When is Naltrexone contraindicated?

A

Liver Failure

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19
Q

Does Naltrexone have a black box warning, and if so, what is it?

A

Yes; Hepatotoxicity

20
Q

Name 4 ways Naloxone can be administered

A

IN, IM, SC, IV

21
Q

Is Naloxone short acting or long acting?

A

Short Acting

22
Q

What is the clinical usage for Naloxone

A

Opioid Overdose Reversal

23
Q

What is the MOA of Naltrexone

A

Mu-Opioid receptor Antagonist

24
Q

How are the 2 ways Naltrexone administered?

A
  1. PO
  2. IM (30 day depot injection)
25
Q

What is Naltrexone indicated for?

A

Opioid and alcohol relapse prevention.
NOT used for withdrawal!

26
Q

List 2 Partial Mu-Opioid Agonists

A
  1. Buprenorphine
  2. Buprenorphine + Naloxone
27
Q

What are Buprenorphine & Buprenorphine + Naloxone used for?

A

Opioid relapse prevention/ maintenance

28
Q

How are Buprenorphine & Buprenorphine + Naloxone administered?
List 3

A
  1. SL Tabs
  2. SL Film
  3. Extended Release Injection
29
Q

Is there a Black Box Warning for Buprenorphine, and if so, what is it?

A

Yes; Increased risk of respiratory depression when combined with alcohol/ BZD

30
Q

Describe the MOA of Methadone

A

Mu-Opioid Receptor Agonist

31
Q

Describe how Methadone is administered

A

Orally; Liquid

32
Q

Is there a Black Box Warning for Methadone, and if so, what is it?

A

Yes; Increased risk of respiratory depression when combined with alcohol/ BZD

33
Q

Describe the clinical usage of Methadone

A

Opioid relapse prevention/maintenance

34
Q

Describe the MOA of Clonidine

A

Alpha-2 Adrenergic Agonist

35
Q

What is a common side effect of Clonidine?

A

Hypotension

36
Q

Describe the clinical use for Clonidine

A

Manages symptoms of acute & post-acute opioid withdrawal

37
Q

How is Clonidine administered?

A

PO & Patch

38
Q

Describe the MOA of Nicotine Replacement

A

Nicotine receptor agonist

39
Q

List 3 ways Nicotine replacement can be administered

A
  1. Gum (Nicorette)
  2. Patch (Nicoderm)
  3. Lozenges
40
Q

Describe the MOA Bupropion

A

Norepinephrine - DA reuptake inhibition

41
Q

List how Bupropion is administered

42
Q

What is an additional indication for Bupropion?

A

Antidepressant

43
Q

Describe the MOA for Varenicline

A

Nicotinic receptor partial agonist

44
Q

List 4 side effects of Varenicline

A
  1. Nausea
  2. Vivid dreams
  3. Headaches
  4. Rash
45
Q

Is there a Black Box Warning for Varenicline, and if so, what is it?

A

Yes; Depression & Suicidality (Removed in 2016)

Essentials 1.3 Pharma-Explosion (5 decks)

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