Substance Use Disorders Flashcards
Substance Use Disorders
- Alcohol Use Disorder
- Sedative, Hypnotic, Anxiolytic Use Disorder
- Stimulant Use Disorder
- Inhalant Use Disorder
- Opioid Use Disorder
- Hallucinogen Use Disorder
- Cannabis Use Disorder
DSM-V Criterion for Substance Abuse Disorders
- Criterion 1: Larger amounts or longer period than intended
- Criterion 2: Persistent attempts to cut down
- Criterion 3: Much time obtaining substance, using or detoxing
- Criterion 4: Intense desire or “urge”
- Criterion 5: Inability to maintain role functions
- Criterion 6: Continues use despite interpersonal problems
- Criterion 7: Withdrawal/isolation
- Criterion 8: Hazardous activities while using
- Criterion 9: Use despite knowledge of physical/psychological harm
- Criterion 10: Tolerance
- Criterion 11: Withdrawal
Now, two or more of 11 criteria need to be present for a diagnosis of SUD-Mild. For SUD-Moderate, it’s four or more, and for SUD-Severe, it’s six or more.
SUD
Predisposing Factors
Biological Factors
Genetics- Research to date has led to the identification of several genes that seem to influence the risk of alcohol dependence
Biochemical-
• Products of alcohol metabolism interact with dopamine and serotonin to produce morphine-like substances
• Opiates, such as heroin, mimic natural opiate-like neurotransmitters such as endorphins
• Stimulants, such as cocaine, block the reuptake of dopamine, serotonin, and norepinephrine.
SUD:
Predisposing Factors
Psychological Factors
• Emotion- difficulty expressing emotions, substance may become a form of self-medication
• Personality- low self-esteem, depression, passivity, inability to relax or to delay gratification
Sociocultural Factors
• Social Learning- modeling, imitation, identification
• Cultural and Ethnic Influences- differences in how substance use is viewed, most notable differences are with alcohol
SUD:
Lifespan Considerations
- Half of U.S.12 and up are current drinkers
- 23% of that half are current binge drinkers
- 6.7% of that half use heavily
- In 2012, 24% of 12th graders had one binge drinking episode during previous two weeks
- In 2012, 24% of 12th graders binge drinking once during previous two weeks
Alcohol Use Disorder
- Depressant effect on CNS
- Most widely abused drug in the U.S.
- Alcoholism is number one health problem
- Third leading cause of preventable death
- Heavy drinking contributes to heart disease, cancer and stroke
Alcohol: Effects on the Body
• Peripheral Neuropathy/Alcoholic Myopathy • Wernicke Encephalopathy/Korsakoff’s Psychosis • Esophagitis/Gastritis • Pancreatitis/Alcoholic Hepatitis • Cirrhosis – Portal Hypertension – Ascites – Esophageal Varices – Hepatic Encephalopathy • Leukopenia/Thrombocytopenia
Possible Consequences of Drinking While Pregnant:
Fetal Alcohol Syndrome
Alcohol Intoxication
- Euphoria
- Disinhibition/Impulsivity
- Mood Lability/Depression
- Impaired Judgment/Attention
- Slurred Speech
- Incoordination/Unsteady Gait
- Nystagmus
- Flushed Face
Blood Alcohol Level (BAL)
• BAL can be measured by blood test,
breathalyzer or urine sample
• 0.08% or above is legally intoxicated
• 0.400% - 0.700% death is possible
Alcohol Withdrawal
DSM-V criteria
– Cessation of alcohol use that has been heavy and prolonged followed by 2 or more of the symptoms below:
• Autonomic hyperactivity (elevated Blood pressure, Elevated HR)
• Increased hand tremor
• Insomnia
• Nausea or vomiting
• Transient auditory, visual or tactile hallucinations
• Psychomotor agitation
• Anxiety
• Generalized tonic-clonic seizures
Medications Used for Alcohol Withdrawal
• Alcohol/Depressants
– Benzodiazepines (Substitution Therapy and taper off)
• Valium
• Librium
• Ativan (the benzodiazepine best tolerated by patients with advanced liver disease)
(Delirium Tremens DTs)
Peak: 2nd or 3rd day (48-72 hours) • Autonomic hyperactivity • Severe disturbance in sensorium • Perceptual disturbances • Fluctuating levels of consciousness • Delusions, agitated behavior, fever
Sedative, Hypnotic, and Anxiolytic Use Disorder
- CNS depressants
- Tranquilizing relief of anxiety to anesthesia, coma and even death
- Effects are additive with one another
- Combination of alcohol and any of these can be fatal
- Physiological and psychological addiction very similar to alcohol
- Cross-tolerance
- Cross-dependence
Sedative, Hypnotic, and Anxiolytic Drugs
• Barbiturates- short-term sleep, pre-anesthesia, seizures – Phenobarbital • Nonbarbiturate Hypnotics- mostly for sleep – Eszoplicone (Lunesta) – Zolpidem (Ambien) • Antianxiety Agents (Benzodiazepines) – Chlordiazepoxide (Librium) – Diazepam (Valium) – Lorazepam (Ativan) – Clonazepam (Klonopin) • Club Drugs (Illegal) – Flunitrazepam (Rohypnol) – Gamma hydroxybutyrate (GHB)
Sedative, Hypnotic or Anxiolytic Effects on the Body
- Barbiturates increase amount of sleep time in the dreaming phase
- Respiratory Depression
- Hypotension
- Decreased cardiac output
- May suppress renal function
- Can greatly decrease body temperature
- Initial increase in libido followed by decreased ability to function
Sedative, Hypnotic, Anxiolytic Intoxication and Withdrawal
- Intoxication: decreased inhibition, impulsivity, mood lability, impaired judgment/attention/memory, slurred speech, unsteady gait, nystagmus, stupor or coma
- Withdrawal: autonomic hyperactivity, hand tremor, nausea or vomiting, hallucinations, illusions, psychomotor agitation, anxiety, orthostatic hypotension or seizures
Stimulant Use Disorder
• In 2010, about 1.5 millions Americans were current cocaine users, highest use among ages18-25
• Effects on Body
– CNS- tremor, restlessness, anorexia, insomnia, agitation
– Cardiovascular/Pulmonary- increased HR and BP, cardiac arrhythmias, Cocaine intoxication can lead to MI due to these effects. Inhaled cocaine can cause pulmonary hemorrhage, chronic bronchiolitis, and pneumonia
– GI and Renal- constipation, various degrees of anorexia, difficulty urinating
Stimulant Drugs
• Amphetamines
– Methamphetamine (Desoxyn)
– Amphetamine + Dextroamphetamine (Adderall)
https://www.youtube.com/watch?v=evhM47sUIt0#action=share – Lisdexamfetamine Dimesylate (Vyvanse) • Synthetic Stimulants – Methylenedioxypyrovalerone (MDPV) “Bath Salts” • Nonamphetamine Stimulants – Benzphetamine (Didrex) – Methylphenidate (Ritalin) • Cocaine • Caffeine • Nicotine