substance use disorders

Question 1

management of alcohol intoxication

Answer 1

supportive treatment

Question 2

management of alcohol withdrawl

Answer 2

can be lethal
benzodiazepines

Question 3

medications for alcohol dependence

Answer 3

naltrexone- stop during relapse
contraindicated in liver failure
acamprosate: continue through relapse
can cause kidney stones
disulfiram: aversive therapy

Question 4

management of benzodiazepine overdose

Answer 4

flumazenil: competitive antagonist

Question 5

cannabinoid antagonist

Answer 5

Rimonabant

Question 6

PCP MOA

Answer 6

NMDA antagonist

Question 7

LSD MOA

Answer 7

5HT2A receptor agonist

Question 8

treatment for PCP intoxication

Answer 8

symptomatic
benzodiazepines
ammonium chloride or cranberry juice to acidify the urine

Question 9

Treatment of LSD intoxication

Answer 9

diazepam 20 mg PO
can try to talk down

Question 10

Inhalant MOA

Answer 10

direct releasers of dopamine in the nucleus accumbens

Question 11

inhalant intoxication treatment

Answer 11

symptomatic- should resolve on its own

Question 12

Opioid MOA

Answer 12

enkephalin released to mu receptor in VTA and NA

Question 13

opioid intoxication treatment

Answer 13

symptomatic
naloxone for overdose- will need many doses due to half life

Question 14

opioid withdrawal treatment

Answer 14

methadone: opioid agonist
buprenorphine: partial agonist

Question 15

stimulant MOA

Answer 15

release dopamine or block reuptake of dopamine

Question 16

Nicotine MOA

Answer 16

release dopamine in the VTA through alpha4beta2 and alpha7

Question 17

treatment for nicotine withdrawal

Answer 17

nicotine replacement therapy
bupropion: use nicotine replacement
varenicline: don’t use nicotine replacement

Question 18

what is special about varenicline

Answer 18

partial agonist
contraindication if suicidal ideation or mood instability