Substance Related and Addictive Disorders Flashcards
substance
- Any natural or synthesized product that has psychoactive properties.
- Acts primarily upon the central nervous system where it alters brain function. (crosses blood brain barrier)
- Acute/temporary changes in perceptions, thoughts, emotions, and behaviors.
Main Categories
!Depressants ! Stimulants ! Opioids ! Cannabis ! Hallucinogens ! Other drugs of abuse Inhalants Anabolic steroids Medications ! Gambling disorder -We look at "what things are being given up?"
only behavioral disorder
gambling
Substance Use Disorders in the USA
About 9% of all teens and adults in the U.S. display
substance use disorders
• Lowest rate among Asian Americans (3.5%)
• White Americans, Hispanic Americans, and African
Americans display rates between 9-10%
• Only 11% receive treatment from a mental health
professional
Immigration Paradox
Immigrants to the United States, relative to the native born, are less likely to initiate and develop substance use disorders.
- -The paradox is that, despite having disproportionately lower income and education levels, immigrants are often healthier than their native-born counterparts.
- immigration is stressful & this not only exists in substance abuse disorder but can be seen across other health aspects
The Criteria (within 12-month period)
- Taking the substance in larger amounts or for longer than intended
- Wanting to cut down or stop using the substance but not managing to
- Spending a lot of time getting, using, or recovering from use of the substance
- Cravings and urges to use the substance
- Not managing to do what you should at work, home or school, because of substance use
- Continuing to use, even when it causes problems in relationships
- Giving up important social, occupational or recreational activities because of substance use
- Using substances again and again, even when it puts you in danger
- Continuing to use, even when the you know you have a physical or psychological problem that could have been caused or made worse by the substance
- Tolerance
- Withdrawal
Severity
Depends on number of symptom criteria endorsed
Mild: 2-3 symptoms
Moderate: 4-5 symptoms
Severe: 6 or more symptoms
Addiction
you cannot be addicted to anything
-substance abuse can rob people of insight
#9» good example is depression
Tolerance
- Requires increasingly greater amounts of the drug
to experience same/desired effect.
OR - Markedly diminished effect with continued use of
same amount
Physiological reaction
-Examples»_space; cigarettes
Withdrawl
- Characteristic withdrawal syndrome for substance
- Same (or closely related) substance take to relieve
or avoid withdrawal
– Sometimes substance must be withdrawn gradually
– Symptoms tend to be the opposite of drug’s direct
effect on body
Specifiers
# In early remission: no criteria for > 3 months but 12 months (except craving) # In a controlled environment: access to substance restricted (ex. Jail)
Substance-Induced
" Intoxication " Withdrawal " Psychotic Disorder " Bipolar Disorder " Depressive Disorder " Anxiety Disorder " Sleep Disorder " Delirium " Neurocognitive " Sexual Dysfunction
DSM5 Criteria
Substance Use Disorder: addressed as a separate
use disorder (e.g., alcohol use disorder, stimulant
use disorder, etc.)
–Major change from DSM-IV to DSM5 was to remove
the criterion related to legal problems and to add
one related to substance craving
Depressants
Decrease CNS functioning
less neuronal firing (increases GABA and suppresses glutamate)
–Slurred speech, decreased motor functioning, memory impairments,
perceptual slowing, less inhibition
Alcohol use in the USA
24% of all people in the U.S. over the age of 11, most of them male,
binge-drink each month
• Nearly 7% of people over age the age of 11 binge-drink at least 5 times
each month
• Considered heavy drinkers, males outnumber females by more than 2:1
(around 8% to 4%)
-42% of college aged report binge drinking
Alcohol
•The first brain area affected is that which controls judgment and inhibition • Next affected are additional areas in the CNS, leaving the drinker even less able to make sound judgments, speak clearly, and remember well • Motor difficulties increase as drinking continues, and reaction times slow
Depressants: Alcohol
• The extent of the effect of alcohol is determined by
its concentration (proportion) in the blood
• A given amount of alcohol has a lesser effect on a
large person than on a small one
• Gender also affects blood alcohol concentration
• Women have less alcohol dehydrogenase, an enzyme
in the stomach that metabolizes alcohol before it
enters the blood
• Women become more intoxicated than men on equal
doses of alcohol
Difference in if you are a fast or slow metabolizer & big difference in gender
Slow metabolizer
for a certain substance is a protective factors
Asian countries
small alcohol abuse
except for South Korea b/c of culture
Alcohol Level of impairment
closely tied to the
concentration of ethyl alcohol in the blood:
–BAC = 0.06: Relaxation and comfort
– BAC = 0.09: Intoxication
–BAC > 0.55: Death
– Most people lose consciousness before they can drink this
much
Metabolic Tolerance
The liver reacts to greater
consumption of alcohol by producing more of the
enzyme (alcohol dehydrogenase) that metabolizes
alcohol. In chronic users, this can result in the
significantly faster metabolization of alcohol.
—-The increase in alcohol dehydrogenase (toxic) is one factor that leads to the destruction of the liver in chronic users.
Functional Tolerance
sway test standing on line
Mild alcohol withdrawal
occurs within 24 hours of last drink. tremulousness (shakes),
insomnia, anxiety, panic, twitching, sweating, raised blood pressure
and pulse, and stomach upset
(most people experience this)
moderate alcohol withdrawal
usually occurs 24-36 hours after the cessation of alcohol
intake. Intense anxiety, tremors, insomnia, seizures, hallucinations,
high blood pressure, racing pulse.
severe alcohol withdrawal
Delirium Tremens (D.T.s). More than 48 hours after a
cessation or decrease in alcohol consumption. Disorientation,
agitation, hallucinations, racing heart, rapid breathing, fever, irregular
heartbeat, blood pressure spikes, and intense sweating.
(had to be drunk for a very very long time)
Delirium Tremens
! Delirium, Hallucinations, Extreme, Fluctuations in Blood Pressure,
Grand mal seizures, Heart attacks!
Alcohol withdrawal
• When untreated about one person in five will die of
D.T.s. Some people refer to shakes as D.T.s but this
is inaccurate.
• Even mild or moderate withdrawal can be
dangerous for people with high blood pressure or
bad hearts.
• Withdrawal raises blood pressure ! danger of heart
attack or stroke. The longer and harder a person has
drunk alcohol–the more severe the withdrawal will be.
Alcohol subsiding
Nothing can lower BAC except time •The effects of alcohol subside only after alcohol is metabolized by the liver •The average rate of this metabolism is 25% of an ounce per hour •You can’t increase the speed of this process!
Alcohol culture
•People in countries who combine alcohol with meals (France) have lower alcohol-related substance disorders •Empty stomach results in rapid delivery of alcohol into blood stream. (more likely to black out) •Full stomach slows rate of absorption & more drinks needed to reach dangerous blood levels.
Passing out
•Colloquial term for syncope (loss of consciousness)
•Alcohol lowers blood pressure
•When sober, body constricts veins upon standing up
to increase blood pressure and prevent the person
from passing out as their blood falls due to gravity.
•After consuming 2-3 drinks, alcohol prevents the
blood vessels from constricting, and blood pressure
drops twice as much when the person stands up as it
would if they were sober.
Lose ability to compensate gag reflex while vomiting
Blacking out
Picture—
alcohol impacts the transfer from short term memory to long term memory
Blacking out once makes you more vulnerable to black out
black out a little or a lot
Hangover
• Vasopressin • Normally vasopressin repurposes water released by the kidneys back into the body. • Absence of vasopressin, that water is marked for the bladder and eliminated. • Alcohol also causes inflammation of the stomach lining, which can cause diarrhea -- another dehydrating condition. • Acetaldehyde toxicity
Sedative-Hypnotic Drugs
Sedative-hypnotic (anxiolytic) drugs produce
feelings of relaxation and drowsiness
• At low doses, they have a calming or sedative effect
• At high doses, they function as sleep inducers or
hypnotics
• Sedative-hypnotic drugs include barbituates and
benzodiazepines
Barbituates &
Benzodiazepines
•Barbituates (seconal, nembutal): sedative drugs prescribed for sleep (decrease in use post-1960)
•Benzos (valium, xanax, rohypnol): reduce anxiety
•less dangerous than barbituates but still carry significant addiction potential if used incorrectly.
•Intoxication symptoms similar to alcohol.
•High doses; diaphragm muscles relax so much that they
cause death by suffocation.
• OD on barbs common form of suicide
• Synergistic effect with alcohol
Barbituates
considered old school-easily overdosed & now used in lethal injections
intoxication agnosognia
lack of insight
Alcohol & Benzos
•Marilyn Monroe may have unintentionally killed herself with this combo • Heath Leger barbs, benzos, & pain killers • Whitney Houston xanax, cocaine • Medication “spellbinding:” individuals have no idea how badly they are being impaired
Benzodiazepine Withdrawal
• Overwhelming anxiety and panic, insomnia (far worse
than the individual has ever before experienced).
• Irritability ! uncontrollable anger & violence (at
extreme).
• Muscle spasms, painful feelings in the extremities,
painfully-heightened awareness of diminished mental
faculties, confusion, depression, suicidality, paranoia,
hallucinations
• Weeping, terror, negative looping thoughts (severe)
• Keep in mind CONTINUUM (mild, moderate, severe)
You have to wean off the benzos
Opioids
Pain relief, sedation,
euphoria, slowed breathing
opiate
any natural
chemical deriving from
opium poppy
opioid
all inclusive term for natural opiates, synthetic variations (heroin, methadone, oxycodone), & the comparable substances in brain
Morphius
God of Sleep