Substance/Medication-Induced Depressive Disorder

Question 1

Substance/Medication-Induced Depressive Disorder

Answer 1

A. A prominent and persistent disturbance in mood that predominated the clinical picture and is characterized by depressed mood or markedly diminished interest or pleasure in all, or almost all, activities.

B. There is evidence from the history, physical examination, or laboratory findings of both (1) and (2):

1) The symptoms of Criterion A developed during or soon after substance intoxication or withdrawal or after exposure to or withdrawal from a medication.
2) The involved substance/medication is capable of producing the symptoms in Criterion A.

C. The disturbance is not better explained by a depressive disorder that is not substance/medication-induced. Such evidence of an independent depressive disorder could include the following:
–The symptoms preceded the onset of the substance/medication use; the symptoms persist for a substantial period of time (e.g., about 1 month) after the cessation of acute withdrawal or severe intoxication; or there is other evidence suggesting the existence of an independent non-substance/medication induced depressive disorder (e.g., a history of recurrent nonsubstance/medication-related episodes)

D. The disturbance does not occur exclusively during the course of a delirium.

E. The disturbance causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

NOTE: This diagnosis should be made instead of a diagnosis of substance intoxication or substance withdrawal only when the symptoms in Criterion A predominate in the clinical picture and when they are sufficiently severe to warrant clinical attention.

Question 2

Substance/Medication-Induced Depressive Disorder Specifiers

Answer 2

With Mild Use Disorder
With Moderate or Severe Use Disorder
Without Use Disorder

Alcohol
Phencyclidine
Other Hallucinogen
Inhalant
Opioid
Sedative, Hypnotic, or Anxiolytic
Amphetamine-Type Substance (or Other Stimulant)
Cocaine
Other (or Unknown) Substance

–With Onset During Intoxication: If criteria are met for intoxication with the substance and the symptoms develop during intoxication
–With Onset During Withdrawal: If criteria are met for withdrawal from the substance and the symptoms develop during, or shortly after, withdrawal.
–With Onset After Medication Use: If symptoms developed at initiation of medication, with a change in use of medication, or during withdrawal of medication.