STUDY YAAAAAS Flashcards
Predialysis Energy: 30-35 kcal/kg dry weight PRO: 0.6-0.8 g/kg dry wt. FAT: 30% of kcal and 10% or less saturated Fluid: 500 mL/day + urine output
Dietary recommendations for Predialysis, Dialysis, Polycystic Kidney Disease (PKD)
- K: 4000 mg stages 2-3 and 2400 mg stages 4-5
- Vitamins: no vitamin A b/c @ toxicity risk
- Avoid high K foods like noni-juice and star fruit
Dietary recommendations for Predialysis, Dialysis, Polycystic Kidney Disease (PKD)
Dialysis PRO: 1.0-1.5 g PRO/kg dry wt. FAT: 30% of kcal and 10% or less saturated Fluid: 1000 mL/day + urine output *Prealbumin is always false high*
Dietary recommendations for Predialysis, Dialysis, Polycystic Kidney Disease (PKD)
Hereditary: Grape-like cysts and as cysts obstruct/occlude
Lost salt w/ high urine output — increase salt intake
Dietary recommendations for Predialysis, Dialysis, Polycystic Kidney Disease (PKD)
Treatment for Hypercalciuria
K+ wasting diuretic (thiazide diuretic)
Phos: restricted to 800-1600 mg/day
K: restrict to 1500-3000 mg/day (39 mg = 1 mEq)
Na: 2000 mg/day
Dialysis
1 mEq K =
39 mg
1 mEq Na =
23 mg of Na
Norvasc
Ca Channel blocker for high BP – NO ____________!
Norvasc and Rocaltrol: functions, etc.
NO GRAPEFRUIT!
Rocaltrol (calcitriol)
Active vitamin D (1,25 – Dihydroxycholecalciferol)
Binds to Ca and inc. absorption – hypercalcemia risk
Treats elevated iPTH in CKD pt.
Norvasc and Rocaltrol: functions, etc.
Wt. gain between dialysis treatments should NOT exceed 1-2 lbs/day
Common to see 2-4 lb gains from Mon-Wed and 3-5 lb gains over the weekend
Look at pre and post dialysis weight and interpret fluid status: good or bad?
Hectoral, Zemplar –> derivatives of Vit. D
High blood phosphorus and low blood Ca can stimulate body to produce iPTH
Sensipar – helps control hyperparathyroidism
More effective @ lowering iPTH than vit. D
Meds. used to treat elevated iPTH in CKD pt.
BUN and Creatinine – always high
Retinol Binding Protein (RBP) – carries vitamin A in blood, generally false high and not ideal marker
Look at albumin and changes overtime
Look at renal pt. lab value and make assessment of PRO status
Calcium channel blocker for high BP
No Grapefruit or Seville oranges
Pt. on Norvasc: if any food med. interactions
Management: maintain normal serum phosphorus, calcium, and parathyroid hormone levels
Parameter Target Range
Corrected total serum Ca = 8.4-9.5 mg/dl
Serum Phosphorus = 3.5-5.5 mg/dl
Ca x P = 22 mEq/L
Pt. on HD is @ risk for renal bone disorder (osteodystrophy): what tx plan to decrease risk?
Hyperphosphatemia Mgmt: severe = serum ___—___ mg/dL
If serum P is less than 7 mg/dL then Ca supp. may be used to bind P
avoid Ca supp. as long as possible b/c @ risk for soft tissue calcification
Pt. on HD is @ risk for renal bone disorder (osteodystrophy): what tx plan to decrease risk?
7-15
Decrease or avoid vit. D andCa
Hypercalcemia Mgmt:
________– Calcium-sensing Receptor (CaR) modulator , help control hyperparathyroidism
help control hyperparathyroidism
*Sensipar
Vitamin D Therapy – will help suppress iPTH and help normalize serum Ca
1,25 dihydroxy D3
Hectoral oral or IV (doxercalciferol) and Zemplar: vitamin D2
Pt. on HD is @ risk for renal bone disorder (osteodystrophy): what tx plan to decrease risk?
Parathyroidectomy – if all else fails to dec. iPTH, remove parathyroid
Calcific Uremic Arteriolopathy (calciphalaxis) – keep iPTH and Ca levels normal to prevent this
Pt. on HD is @ risk for renal bone disorder (osteodystrophy): what tx plan to decrease risk?
cardiac problems like arrhythmias, weakness, GI problems, death
Hyperkalemia
Hypoguesia, Hyposmia, poor appetite, rash, poor wound healing, immune and sexual dysfunction, poor growth in kids
Avoid laxatives w/ magnesium: Milk of Magnesia and Mineral Oil
Zinc deficiency
Muscular weakness, cardiac arrhythmias (irregular heart beat), high plasma TG
Carnitine deficiency
inc. iron absorption and serum ferritin is > **300mg/dL
Hereditary disorder where iron stores may reach 20-40 grams (N= 1-3 grams)
Hemochromatosis
S and S: cirrhosis, liver cancer, diabetes, bronze skin, cardiomyopathy, arrhythmias, heart failure, abdominal pain, arthritis
Hemochromatosis
Antioxidant –> anticancer, anti-diabetic, anti-atherosclerotic
Promotes muscle development, decrease fat deposition
May lower plasma TC, TG, and; improve utilization of FA by heart
Found in beef, lamb, turkey, and dairy fats
What is CLA? – Conjugate Linoleic Acid
Stanol ester –> blocks cholesterol absorption
2-3 g/day will lower LDL by 6-15%
What is Benecol? — Stanol Ester
Need 5-50 mg/day B6 supp.
Management of Wilson’s disease and Rheumatoid Arthritis
Penicillamine
Lose weight if obese, low fat diet
Limit alcohol and high glycemic index CHO
Dietary recommendations for pt. w/ Familiar Dislipidemia
combines 3 or more HIV drugs to dec. viral load
Take a multi-vitamin mineral supplement daily and avoid food borne illnesses
AIDS pt w/ different disorders of large or small bowel: what recommendations to make
“Highly Anti-Retroviral Therapy” (HAART) -
Due to hyperlipidemia:
Maintain IBW, 30% kcal from FAT, lower saturated, trans fats, and TG (simple sugars)
Increase physical activity
AIDS pt w/ different disorders of large or small bowel: what recommendations to make
“Highly Anti-Retroviral Therapy” (HAART) -
- Diarrhea*
- Severe small bowel disease – often parenteral nutrition required
- Partial small bowel disease – fat >20% kcals, low fiber/residue, lactose free, avoid caffeine; but rarely parenteral nutrition is required
- Large bowel problems – same as above
AIDS pt w/ different disorders of large or small bowel: what recommendations to make
Exercise and lose weight if obese Avoid elevated or low plasma TG Intake smaller amounts of alcohol Statins and Niacin Stop smoking Avoid androgenic and anabolic steroids Avoid beta andrengenic blocking agents
Ways to help elevate HDL
Statins lower CRP
Decreased by stop smoking, omega 3 FA, exercise, avoid android obesity, more sleep, reduce stress
Therapies to lower CRP
Ex. RA, lupus**, cancer, chronic infections, inflammatory bowel disease (IBD)
Diseases associated w/ being a cause of Anemia of Chronic Disease
Salt substitutes – Morton lite and cardia
Squash, noni juice and star fruit
Foods high in potassium
Retinol Binding Protein – carries vit. A and always elevated, causing a false high pre-albumin
Albumin – physiological stress and PRO malnutrition causes low albumin
Trying to assess hemodialysis pt. PRO status: pro and cons w/ looking at RBP vs. albumin
Cyclosporine
Hypomagnesmia, hyperkalemia, hyperlipidemia, increase BG, and hyperuricemia
Don’t take with grapefruit
Side effects of Cyclosporine, Mineral Oil, Cholestyramine, and Methotrexate
Mineral Oil
May reduce absorption of vitamin A,D,E,K, calcium, carotenoids, and phosphate
Side effects of Cyclosporine, Mineral Oil, Cholestyramine, and Methotrexate
Cholestyramine
Always mix the powder into liquid
Long term therapy – depletion of fat soluble vitamins so vit. A, D, E, K supp. recommended
Folic acid deficiency may occur and 5 mg supp. recommended
Side effects of Cyclosporine, Mineral Oil, Cholestyramine, and Methotrexate
Methotrexate
If chemotherapy agent – avoid folate
If taken for other disorders, folate supplement may be taken prophylactically
Side effects of Cyclosporine, Mineral Oil, Cholestyramine, and Methotrexate
This leads to exudative diarrhea - Inflammation of gut, excretion of blood, mucus, plasma proteins, and electrolytes
Pt. has Radiation Enteritis, and Ulcerative Colitis (UC): what kind of diarrhea would they have
Which antacid is most likely to cause diarrhea
Milk of Magnesia
Serum or plasma folate 100 mg FIGLU excretion*
Folate (B9) and Cobalamin (B12) anemia: lab test and abnormalities in complete blood count
Folate (B9)
- High Methamalonic Acid (MMA) > 3.5 mg*
* Schilling Test (B12 absorption) – deficient if less urine excretion*
Folate (B9) and Cobalamin (B12) anemia: lab test and abnormalities in complete blood count
Cobalamin (B12)
Levadopa
High PRO – decrease drug’s effectiveness, eat less PRO at night
B6 can convert L-dopa to dopamine outside the brain → lessening the effect
Possible interactions and things to avoid: LDOPA, Tetracycline, Nardil, and Isoniazid
Avoid high fortified foods (ex. cereal) and; supplements of B6 – don’t completely eliminate though
Don’t take with iron – absorption is decreased
Levadopa
Tetracycline
Calcium, iron, magnesium – form a chelate, reducing absorption of both the med and mineral
Should not be taken 3 hours before or 2 hrs. after – divalent or trivalent cations or Na bicarb.
Possible interactions and things to avoid: LDOPA, Tetracycline, Nardil, and Isoniazid
Can alter activity of folate, K, B6, B12, vit. C and K if longer than 2 weeks (may need supplement)
Taking 500 mg vit. C w/ drug may increase blood levels of med
Tetracycline
INH (Isoniazid)
Avoid Swiss/Cheshire cheese, tuna, skipjack, sardinella – histamine and tyramine containing foods
Interferes w/ B6 metabolism – interferes w/ PLP and excretion of both is increased
Possible interactionsand things to avoid: LDOPA, Tetracycline, Nardil, and Isoniazid
PLP is needed to convert tryptophan to Niacin**, so 200-400 mg/day of niacin – with pellegra
INH (Isoniazid)
MAOI’s Nardil
Avoid consumption of high tyramine*** foods
Cheese, smoked/pickled fish, non-fresh meat and liver, chianti and vermouth wine, broad beans, banana peels, meat extracts, yeast extract, dry sausage, sauerkraut, beer and ale
Possible interactions and things to avoid: LDOPA, Tetracycline, Nardil, and Isoniazid
Chron’s disease and ulcerative colitis; inflammation* of the bowel
Inflammatory Bowel Disease
Possible cause - bacterial overgrowth in the SI, hypermotility or abdominal brain gut connection exacerbated by stress
Irritable Bowel Syndrome (Spastic Colon)
Signs and Symptoms: gas, bloating, abdominal pain, cramps, spastic contractions, constipation and/or diarrhea, fecal incontinence, anxiety, back pain, mucous in stool
Irritable Bowel Syndrome (Spastic Colon)
For Hypertension:
2-3 servings/day of low fat dairy products - on the test it says 5 servings/day so it won’t be the answer
7-8 servings per day of whole grain
8-10 servings/day of fruit and vegetables
DASH diet: what it’s high and low in
Polyuria, polydipsia, or oliguria
Low plasma albumin – due to loss of PRO in urine
Look at pt. lab values, S and S: determine whether they have Nephrotic Syndrome, Carnitine deficiency, Polycystic kidney disease, and Acute Glomerulonephritis
Nephrotic Syndrome
Most common in kids 3-21 yrs. who have had beta hemolytic group A strep infection
Hematuria, albuminuria, azotemia, HTN, and edema
Look at pt. lab values, S and S: determine whether they have Nephrotic Syndrome, Carnitine deficiency, Polycystic kidney disease, and Acute Glomerulonephritis
Acute Glomerulonephritis
Hematuria, proteinuria, infection, and flank pain
Look at pt. lab values, S and S: determine whether they have Nephrotic Syndrome, Carnitine deficiency, Polycystic kidney disease, and Acute Glomerulonephritis
Polycystic Kidney Disease
Muscular weakness
Cardiac arrhythmias (irregular heart beat)
High plasma TG
Look at pt. lab values, S and S: determine whether they have Nephrotic Syndrome, Carnitine deficiency, Polycystic kidney disease, and Acute Glomerulonephritis
Carnitine Deficiency
Absorbed in the bloodstream and provides quick energy for body and not as likely to be stores as fat
Acts as a CHO not FAT and goes to liver to be used as an immediate energy source
MCT oil: how it’s absorbed and possible side effects
Side Effects:
Ketone build up in DM, cause severe problems in liver disease, and upset stomach
MCT oil: how it’s absorbed and possible side effects
Ulcerative Colitis (UC) – DON’T go on TPN
Crohn’s - may help pt. go into remission
Severe vomiting and Diarrhea
Any disease of the SI causing malabsorption
Look at pt.’s condition and determine whether they need to be on TPN or not
High output (over 500) fistula
Short bowel/ major surgical resection
Severe gastritis or bleeding ulcers
Look at pt.’s condition and determine whether they need to be on TPN or not
Acute bowel ischemia, severe total ileus, and severe acute pancreatitis
Complete mechanical bowel obstruction
Severe damage to a large part of the SI
Look at pt.’s condition and determine whether they need to be on TPN or not
Name of formula for Chron’s Disease pts.
MODULEN IBD by Nestle’s – contains TGF-B2 which inhibits IFN-g, lowering MHC Class II PRO
Low in Omega 6 and decreases inflammation of SI
Peptamen – Peptide-based elemental diet for GI-impaired children ages 1-10
Methotrexate: no folate supp. if for chemo and Dilatin: give minimum amt
{refer to #72}
Look at blood values, meds, S and S, and make dx of what is causing their anemia
Macrocytic Anemias
Effect B12:
Pernicious anemia, GI problems, and elderly
Meds: nitrous oxide, cholestyramine, INH, metformin, H2 receptor blockers, PPIs (prolisec and prevacid), Nexium, Dilantin
Look at blood values, meds, S and S, and make dx of what is causing their anemia
MACROCYTIC large RBC’s, high MCV NORMOCYTIC normal size RBC’s, normal MCV MICROCYTIC Small RBC’s, low MCV
CLASSES OF ANEMIA
COPD → chronic obstructive lung disease
Pt. w/ COPD taking Mylanta, Ldopa, Nardil and Warfarin: know side effects, nut. Interactions of these meds, know foods to restrict, or supplements to take
Mylanta – antacid (contains Mg)
Phosphate deficiency risk w/ chronic use – inc. risk w/ low phosphorus and PRO intake
Deficiency risk: vitamin A, folate, thiamin, fluoride, and iron
Pt. w/ COPD taking Mylanta, Ldopa, Nardil and Warfarin: know side effects, nut. Interactions of these meds, know foods to restrict, or supplements to take
not common in CRF pts., heart problems, respiratory problems
Hypophosphatemia
anorexia, hyperreflexia, high heart rate, bone problems, calcification of soft tissues if Ca is also high
Hyperphosphatemia
confusion, GI disturbances, weakness
Hyponatremia
Anticoagulant
Keep steady vit. K intake – large inc. in dose may decrease anticoagulant effects; abrupt decrease may increase effect and result in bleeding
Warfarin: side effects and nutrient interactions
Don’t take CoQ10 – may interact adversely
Don’t take iron, mg, or zinc within 2 hours as absorption may be decreased
Warfarin: side effects and nutrient interactions
CHO = 1.0
FAT = 0.71 (using fat for energy)
PRO = 0.83
RQ mixed diet = @ 0.85
Estimate RQ value of pt. and what is a good value
Ethanol = 0.67; 1.3 = invalid (error in calculation)
RQ of 0.85-0.95 is desirable for pt. on vent
Estimate RQ value of pt. and what is a good value
Jejunal and Ileal resection →Increased risk of hyperoxaluria** and Oxalate Kidney Stones
Make recommendations pt. w/ Short Bowel Syndrome to decrease risk of kidney stones
Avoid high oxalate foods and increase calcium and fluid intake
Avoid: beets, chocolate, coffee, cola, nuts, rhubarb, spinach, strawberries, tea, wheat bran
Make recommendations pt. w/ Short Bowel Syndrome to decrease risk of kidney stones