study guide exam 1 Flashcards
what are the 4 lobes of the brain
frontal, parietal, occipital, temporal
what are the 4 parts of the limbic system
hippocampus, amygdala, anterior thalamus, hypothalamus
describe the frontal lobe
executive function and personality
- maintains & focuses attention, organize thinking, speech & motor activities
- weights consequences , set goals, modulates emotions, integrates ideas, emotions & perceptions
describe the parietal lobe
body sensations, maintains focused attention
- motor activités - attention & perception of spatial relations
- processes sensory impulses from thalamus
describe the occipital lobe
vision and visual memory
- reading, language formation, reception of vestibular, acoustic and tactile stimulus (hearing)
describe the temporal lobe
processing of auditory stimuli, emotion, learning, and memory circuits
- gives emotional tone to memories. is involved in making moral judgements, registers acts of aggression
- “warm memory”
describe the limbic system (LOBE)
- paleomammalian brain
- response for emotions, behaviors, LTM, olfaction (smell)
function of hippocampus
LTM for recall, learning, sensory integration
function of amygdala
reward, fear, anxiety, anger, emotion, social behavior, impulsive gut responses
- ex: addiction (no processing)
function of anterior thalamus
relays sensory & motor signals to cerebral cortex along with regulating of consciousness, sleep, and alertness
- ex: insomnia, wake up throughout the night
function of hypothalamus
regulates homeostasis, hunger, thirst, temperature, body functions, corticosteroid production
5 neurotransmitters learned DANGS
dopamine
norepinephrine
GABA
acetylcholine
serotonin
describe acetylcholine
- derived from coenzyme A
- widely distributed in: cortex
- plays a role in: learning, memory, movement
- implication in nicotine dependence
- contributes to excessive arousal of thought with use of cocaine & amphetamines
- tip: feeds addiction
describe GABA (NT Gamma-Amino butyric acid)
- inhibitory NT widely distributed throughout: nervous system
- responsible for: slowing activity of nerve cell
- inhibitory effect involved in: anxiety, agitation, seizures
- involved in sedative effects of benzodiazepines, barbiturates, and ETOH (alcohol)
- helps with relaxation, sleep, slows body and brain down
- tip: calms anxiety
describe glutamate (NT GLU)
- derived from proteins in the diet
- excitatory NT found throughout the brain
- important in learning
- triggered w/ hallucinogens (PCP- acid, LSD, extra psychotic effects)
describe norepinephrine (NT NE)
- derived from tyrosine (amino acid)
- projects broadly throughout the brain
- responsible for arousal & response to stress
- most likely activated in ADHD & anxieties (too much NE)
- cocaine & amphetamines affect the transmission of NE & contribute to the stimulating & pleasurable effects of these drugs
- TIP: fight/flight, energy, appetite, BMR, socializing
describe serotonin (NT 5HT)
- derived from tryptophan (amino acid) (milk, turkey)
- initiates in midbrain & broadly projects throughout the cortex, hypothalamus and limbic system
- receptors found in brain, gut, platelets, and spinal cord
- path most likely involved in pain, movement, sleep, appetite, anxiety, depressive mood mental health disturbances
- tip: LSD & ecstasy have their primary effects in the serotonin pathways. Cocaine, amphetamines, ETOH & nicotine also affect serotonin transmission. SSRIs cause GI upset r/t receptors
- plays a role in sleep regulation, hunger, pain perception, aggression and sexual behavior
describe NT dopamine (DA)
- derived from tyrosine (amino acid)
- projects to amygdala, nucleus accumbens (deep midbrain), through limbic system * many paths
- involved in movement, learning, pleasure, motivation
- 4 pathways: mesolimbic, mesocoritcal, basal ganglia, pituitary, thalamus
- pleasure, socializing, food seeking, reward, addiction
describe mesolimbic path for DA
reward path activated by most drugs of abuse
- path most likely activated in mania, psychosis, schizophrenias (increase DA = flat affect, poverty though/emotion, triggered hallucinations)
- all antipsychotics work by decreasing DA in this path
describe mesocortical path
mediates cognitive and affective sx.
- path is considered one of executive function
- most likely to be activated in depression, catatonia, decreased attention, concentration, mania, schizophrenia
- decreased DA = negative sx.
- antagonist antipsychotics work by decreasing dopamine
describe basal ganglia path
extrapyrimidal system
- path is prominent for motor control
- most likely path activated in Parkinson’s, EPS, movement disorders, coreas
- antagonist antipsychotics work by decreasing DA (but path is also saturated w/ ACH)
- when DA drops = ACH increase which can cause EPS (akathisia, dystonia, TD or peudoparkinsonism)
describe pituitary path
projects from hypothalamus to anterior pituitary
- path considered sexual dysfunction, weight gain, hyperprolactinemia (increase lactation/ breast enlargement in men)
- all antagonist antipsychotics work by decreasing DA
- when DA drops = release of prolactin -> breast enlargement, galatorhea (breast milk secretion) or amenorrhea
NT DA and mental health correlation
- increase DA = schizophrenia, mania, psychosis, + sx.
- decrease DA = depression, Parkinson’s disease
- responsible for: pleasure, socializing, food seeking, reward, addiction
NT NE and mental health correlation
- increase NE: arousal, mania, anxiety states, schizophrenia
- decrease NE: depression
- responsible for: fight/flight, energy, appetite, BMR, socializing