Study Guide Chapter 33 Coronary Artery Disease and Acute Coronary Syndrome Flashcards
Which patient is most likely to be in the fibrous stage of development of coronary artery disease (CAD)?
a. Age 40, thrombus adhered to the coronary artery wall
b. Age 50, rapid onset of disease with hypercholesterolemia
c. Age 32, thickened coronary arterial walls with narrowed vessel lumen
d. Age 19, elevated low-density lipoprotein (LDL) cholesterol, lipid-filled smooth muscle cells
c. Age 32, thickened coronary arterial walls with narrowed vessel lumen
Rational: The fibrous plaque stage has progressive changes that can be seen by age 30. Collagen covers the fatty streak and forms a fibrous plaque in the artery. The thrombus adheres to the arterial wall in the complicated lesion stage. Rapid onset of coronary artery disease (CAD) with hypercholesterolemia may be related to familial hypercholesterolemia, not a stage of CAD development. The fatty streak stage is the earliest stage of atherosclerosis and can be seen by age 20.
What accurately describes the pathophysiology of CAD?
a. Partial or total occlusion of the coronary artery occurs during the stage of raised fibrous plaque
b. Endothelial alteration may be caused by chemical irritants such as hyperlipidemia or by tobacco use
c. Collateral circulation in the coronary circulation is more likely to be present in the young patient with CAD
d. The leading theory of atherogenesis proposes that infection and fatty dietary intake are the basic underlying causes of atherosclerosis
b. Endothelial alteration may be caused by chemical irritants such as hyperlipidemia or by tobacco use
Rational: The etiology of CAD includes atherosclerosis as the major cause. The pathophysiology of atherosclerosis development and resulting atheromas is related to endothelial injury and inflammation, which can be the result of tobacco use, hyperlipidemia, hypertension, toxins, diabetes mellitus, hyperhomocysteinemia, and infection causing a local inflammatory response in the inner lining of the vessel walls. Partial or total occlusion occurs in the complicated lesion stage. Extra collateral circulation occurs in the presence of chronic ischemia. Therefore it is more likely to occur in an older patient
While obtaining patient histories, which patient does the nurse identify as having the highest risk for CAD?
a. A white man, age 54, who is a smoker and has a stressful lifestyle
b. A white woman, age 75, with a BP of 172/100 mm Hg and who is physically inactive
c. An Asian woman, age 45, with a cholesterol level of 240 mg/dL and a BP of 130/74 mm Hg
d. An obese Hispanic man, age 65, with a cholesterol level of 195 mg/dL and a BP of 128/76 mm Hg
b. A white woman, age 75, with a BP of 172/100 mm Hg and who is physically inactive
Rational: This white woman has one unmodifiable risk factor (age) and two major modifiable risk factors (hypertension and physical inactivity). Her gender risk is as high as a man’s because she is over 65 years of age. The white man has one unmodifiable risk factor (gender), one major modifiable risk factor (smoking), and one minor modifiable risk factor (stressful lifestyle). The Asian woman has only one major modifiable risk factor (hyperlipidemia) and Asians in the United States have fewer myocardial infarctions (MIs) than do whites. The Hispanic man has an unmodifiable risk factor related to age and one major modifiable risk factor (obesity). Hispanics have slightly lower rates of CAD than non-Hispanics whites or African Americans
While teaching women about the risks and incidence of CAD, what should the nurse emphasize?
a. Smoking is not as significant a risk factor for CAD in women as it is in men.
b. Women seek treatment sooner than men when they have symptoms of CAD.
c. Estrogen replacement therapy in postmenopausal women decreases the risk for CAD.
d. CAD is the leading cause of death in women, with a higher mortality rate after MI than in men.
d. CAD is the leading cause of death in women, with a higher mortality rate after MI than in men.
Rational: CAD is the number-one killer of American women and women have a much higher mortality rate within 1 year following MI than do men. Smoking carries specific problems for women because smoking has been linked to a decrease in estrogen levels and to early menopause and it has been identified as the most powerful contributor to CAD in women under the age of 50. Fewer women than men present with classic manifestations and women delay seeking care longer than men. Recent research indicates that estrogen replacement does not reduce the risk for CAD, even though estrogen lowers low-density lipoprotein (LDL) and raises high-density lipoprotein (HDL) cholesterol.
Which characteristics are associated with LDLs (select all that apply)
a. Increases with exercise
b. Contains the most cholesterol
c. Has an affinity for arterial walls
d. Carries lipids away from arteries to liver
e. High levels correlate most closely with CAD
f. The higher the level, the lower the risk for CAD
b. Contains the most cholesterol
c. Has an affinity for arterial walls
e. High levels correlate most closely with CAD
Rational: LDLs contain more cholesterol than the other lipoproteins, have an attraction for arterial walls, and correlate most closely with increased incidence of atherosclerosis and CAD. HDLs increase with exercise and carry lipids away from arteries to the liver for metabolism. A high HDL level is associated with a lower risk of CAD.
Which serum lipid elevation, along with elevated LDL, is strongly associated with CAD?
a. Apolipoproteins
b. Fasting triglycerides
c. Total serum cholesterol
d. High-density lipoprotein (HDL)
b. Fasting triglycerides
Rational: Elevated fasting triglyceride levels are associated with cardiovascular disease and diabetes. Apolipoproteins are found in varying amounts on the HDLs and activate enzyme or receptor sites that promote removal of fat from plasma, which is protective. The apolipoprotein A and apolipropotein B ratio must be done to predict CAD. Elevated HDLs are associated with a lower risk of CAD. Elevated total serum cholesterol must be calculated with HDL for a ratio over time to determine an increased risk of CAD
The laboratory tests for four patients show the following results. Which patient should the nurse teach first about preventing CAD because the patient is at the greatest risk for CAD even without other risk factors?
a. Total cholesterol: 152 mg/dL, triglycerides: 148 mg/dL, LDL: 148 mg/dL, HDL: 52 mg/dL
b. Total cholesterol: 160 mg/dL, triglycerides: 102 mg/dL, LDL: 138 mg/dL, HDL: 56 mg/dL
c. Total cholesterol: 200 mg/dL, triglycerides: 150 mg/dL, LDL: 160 mg/dL, HDL: 48 mg/dL
d. Total cholesterol: 250 mg/dL, triglycerides: 164 mg/dL, LDL: 172 mg/dL, HDL: 32 mg/dL
d. Total cholesterol: 250 mg/dL, triglycerides: 164 mg/dL, LDL: 172 mg/dL, HDL: 32 mg/dL
Rational: All of this patient’s results are abnormal. The patient in option c is close to being at risk, as all of that patient’s results are at or near the cutoff for being acceptable. If this patient is a woman, the HDL is too low. The other patients’ results are at acceptable levels.
The nurse is encouraging a sedentary patient with major risks for CAD to perform physical exercise on a regular basis. In addition to decreasing the risk factor of physical inactivity, the nurse tells the patient that exercise will also directly contribute to reducing which risk factors?
a. Hyperlipidemia and obesity
b. Diabetes mellitus and hypertension
c. Elevated serum lipids and stressful lifestyle
d. Hypertension and elevated serum homocysteine
a. Hyperlipidemia and obesity
Rational: Increased exercise without an increase in caloric intake will result in weight loss, reducing the risk associated with obesity. Exercise increases lipid metabolism and increases HDL, thus reducing CAD risk. Exercise may also indirectly reduce the risk of CAD by controlling hypertension, promoting glucose metabolism in diabetes, and reducing stress. Although research is needed to determine whether a decline in homocysteine can reduce the risk of heart disease, it appears that dietary modifications are indicated for risk reduction.
During a routine health examination, a 48-yr-old patient is found to have a total cholesterol level of 224 mg/dL (5.8 mmol/L) and an LDL level of 140 mg/dL (3.6 mmol/L). What does the nurse teach the patient based on the Therapeutic Lifestyle Changes diet (select all that apply)?
a. Use fat-free milk
b. Abstain from alcohol use
c. Reduce red meat in the diet
d. Eliminate intake of simple sugars
e. Avoid egg yolks and foods prepared with whole eggs
a, c, e.
Therapeutic Lifestyle Changes diet recommendations emphasize reduction in saturated fat and cholesterol intake. Red meats, whole milk products, and eggs as well as butter, stick margarine, lard, and solid shortening should be reduced or eliminated from diets. If triglyceride levels are high, alcohol and simple sugars should be reduced
To which patients should the nurse teach the Therapeutic Lifestyle Changes diet to reduce the risk of coronary artery disease (CAD)?
a. All patients to reduce CAD risk
b. Patients who have experienced an MI
c. Individuals with two or more risk factors for CAD
d. Individuals with a cholesterol level >200 mg/dL (5.2 mmol/L)
a.
The Therapeutic Lifestyle Changes diet includes recommendations for all people, not just those with risk factors, to decrease the risk for CAD
A 62-year-old woman has prehypertension (BP 138/88 mm Hg) and smokes a pack of cigarettes per day. She has no symptoms of CAD but a recent LDL level was 154 mg/dL (3.98 mmol/L). Based on these findings, the nurse would expect that which treatment plan would be used first for this patient?
a. Diet and drug therapy
b. Exercise instruction only
c. Diet therapy and smoking cessation
d. Drug therapy and smoking cessation
c.
Without the total serum cholesterol and HDL results, diet therapy and smoking cessation are indicated for a patient without CAD who has prehypertension and an LDL level ≥130 mg/dL. When the patient’s LDL level is 75 to 189 mg/dL with a 10 yr risk for CVD of 7.5% or above, drug therapy would be added to diet therapy. Because tobacco use is related to increased BP and LDL level, the benefit of smoking cessation is almost immediate. Exercise is indicated to reduce risk factors throughout treatment.
What are manifestations of acute coronary syndrome (ACS) (select all that apply)?
a. Dysrhythmia
b. Stable angina
c. Unstable angina
d. ST-segment-elevation myocardial infarction (STEMI)
e. Non-ST-segment-elevation myocardial infarction (NSTEMI)
c, d, e.
Unstable angina, ST-segment-elevation myocardial infarction (STEMI), and non-ST-segment-elevation myocardial infarction (NSTEMI) are conditions that are manifestations of acute coronary syndrome (ACS). The other options are not manifestations of ACS.
Myocardial ischemia occurs as a result of increased oxygen demand and decreased oxygen supply. What factors and disorders result in increased oxygen demand (select all that apply)?
a. Hypovolemia or anemia
b. Increased cardiac workload with aortic stenosis
c. Narrowed coronary arteries from atherosclerosis
d. Angina in the patient with atherosclerotic coronary arteries
e. Left ventricular hypertrophy caused by chronic hypertension
f. Sympathetic nervous system stimulation by drugs, emotions, or exertion
b, d, e, f.
Increased oxygen demand is caused by increasing the workload of the heart, including left ventricular hypertrophy with hypertension, sympathetic nervous stimulation, and anything precipitating angina. Hypovolemia, anemia, and narrowed coronary arteries contribute to decreased oxygen supplY
What causes the pain that occurs with myocardial ischemia?
a. Death of myocardial tissue
b. Dysrhythmias caused by cellular irritability
c. Lactic acid accumulation during anaerobic metabolism
d. Elevated pressure in the ventricles and pulmonary vessels
c.
When the coronary arteries are occluded, contractility ceases after several minutes, depriving the myocardial cells of glucose and oxygen for aerobic metabolism. Anaerobic metabolism begins and lactic acid accumulates, irritating myocardial nerve fibers that then transmit a pain message to the cardiac nerves and upper thoracic posterior roots. The other factors may occur during vessel occlusion but are not the source of pain.
What types of angina can occur in the absence of CAD (select all that apply)?
a. Silent ischemia
b. Nocturnal angina
c. Prinzmetal’s angina
d. Microvascular angina
e. Chronic stable angina
c, d.
Prinzmetal’s angina and microvascular angina may occur in the absence of CAD but with arterial spasm in Prinzmetal’s angina or abnormalities of the coronary microcirculation. Silent ischemia is prevalent in persons with diabetes mellitus and contributes to asymptomatic myocardial ischemia. Nocturnal angina occurs only at night. Chronic stable angina refers to chest pain that occurs with the same pattern of onset, duration, and intensity intermittently over a long period of time
Which characteristics describe unstable angina (select all that apply)?
a. Usually precipitated by exertion
b. New-onset angina with minimal exertion
c. Occurs only when the person is recumbent
d. Characterized by increased duration or severity
e. Usually occurs in response to coronary artery spasm
b, d
Unstable angina is new-onset angina occurring at rest or with minimal exertion and increases in frequency, duration, or severity. Chronic stable angina is usually precipitated by exertion. Angina decubitus occurs when the person is recumbent. Prinzmetal’s angina is
frequently caused by a coronary artery spasm.
Tachycardia that is a response of the sympathetic nervous system to the pain of ischemia is detrimental because it increases oxygen demand and
a. increases cardiac output.
b. causes reflex hypotension.
c. may lead to atrial dysrhythmias.
d. impairs perfusion of the coronary arteries.
d.
An increased heart rate (HR) decreases the time the heart spends in diastole, which is the time of greatest coronary blood flow. Unlike other arteries, coronary arteries are perfused when the myocardium relaxes and blood backflows from the aorta into the sinuses of Valsalva, which have openings to the right and left coronary arteries. Thus the heart has a decreased oxygen supply at a time when there is an increased oxygen demand. Tachycardia may also lead to ventricular dysrhythmia.
The other options are incorrect
Which effects contribute to making nitrates the first-line therapy for the treatment of angina (select all that apply)?
a. Decrease preload
b. Decrease afterload
c. Dilate coronary arteries
d. Decrease HR
e. Prevent thrombosis of plaques
f. Decrease myocardial contractility
a, b, c
Nitrates decrease preload and afterload to decrease the coronary workload and dilate coronary arteries to increase coronary blood supply. The other options are not attributed to nitrates.
The patient has used sublingual nitroglycerin and various long-acting nitrates but now has an ejection fraction of 38% and is considered at a high risk for a cardiac event. Which medication would first be added for vasodilation and to reduce ventricular remodeling?
a. Captopril
b. Clopidogrel (Plavix)
c. Diltiazem (Cardizem)
d. Metoprolol (Lopressor)
a.
Captopril (Capoten) would be added. It is an angiotensin- converting enzyme (ACE) inhibitor that vasodilates and decreases endothelial dysfunction and may prevent ventricular remodeling. Clopidogrel (Plavix) is an antiplatelet agent used as an alternative for a patient unable to use aspirin. Diltiazem (Cardizem), a calcium channel blocker, may be used to decrease vasospasm but is not known to prevent ventricular remodeling. Metoprolol (Lopressor) is a β-adrenergic blocker that inhibits sympathetic nervous stimulation of the heart.