PAD Flashcards
PAD what is it?
Thickening of the artery walls. This results in a progressive narrowing of the arteries of the upper and lower extremities. PAD is strongly related to other types of cardiovascular disease CVD and their risk factors. PAD prevalence increases with age
PAD Pathophysiology
- Leading cause is atherosclerosis, a gradual thickening of the intima (innermost layer of the arterial wall) and media (middle layer of arterial wall)
- This results from deposits of cholesterol and lipids within the vessel walls and leads to progressive narrowing of the artery
- inflammation and endothelial injury play a major role
- atherosclerosis more commonly affects certain segments of the arterial tree. These include: coronary, carotid, and lower extremity arteries. Clinical symptoms occur when vessels are 60-75& blocked
Risk factors for PAD
- Tobacco use (most significant)
- Chronic kidney disease
- Diabetes
- HTN
- Hypercholesterolemia
PAD: Lower extremities
- lower extremity PAD may affect the?
Iliac, femoral, popliteal, tibial, or peroneal arteries. The femoral-popliteal area is the most common site in nondiabetic patients. Patients with diabetes tend to develop PAD in the arteries below the knee
Clinical manifestations of PAD
- Intermittent claudication
- asymptomatic or atypical leg symptoms (burning, hardness, heaviness, knotting, pressure, soreness, tightness, weakness) in atypical locations (ankle, foot, hamstring, hip, knee, shin)
- Paresthesia (numbness/tingling in toes/feet
- Pallor of feet noted in response to leg elevation
- Reactive hyperemia (redness) develops when limb hangs in dependent position (dependent rubor). Skin is shiny and taut with hair loss on lower legs. Pedal, popliteal, or femoral pulses are diminished or absent
- PAD progression involves continuous pain at rest mostly in forefoot or toes and aggravated by limb elevation
Define intermittent Claudication
Ischemic muscle pain that is caused by exercise, resolves within 10 minutes or less with resting, and re reproducable
Most serious complication of PAD
Nonhealing arterial ulcers and gangrene, and may require amputation
PAD Diagnostic Studies
- Doppler US & duplex imaging assess blood flow
- Segmental BPs obtained (using Doppler US & a sphygmomanometer) at the thigh, below the knee, and at ankle level while patient is supine. A drop in segmental BP of >30 mm Hg suggests PAD
- Angiography or magnetic resonance angiography (MRA) delineates location and extent of PAD
PAD Interprofessional Care
The first Tx goal is to reduce cardiovascular risk factors. Tobacco cessation is essential. Aggressive lipid management is essential for all patients with PAD. Both dietary interventions and drug therapy are needed
1) Statins & fibric acid derivative lower LDL and triglyceride levels. HTN and diabetes mellitus also need to be controlled
2) Antiplatelet agents are critical for reducing risk of CVD events and death in patients with PAD. Oral antiplatelet therapy should include 75-235 mg/day of aspirin. Aspirin intolerant patients may take 75 mg of clopidogrel (Plavix) daily
Treatment of intermittent claudication
- Two drugs: cilostazol (Pletal) and pentoxifylline. Cilostazol, a phosphodiesterase inhibitor, inhibits platelet aggregation and increases vasodilation. Pentoxifylline, a xanthine derivative, improves deformability of RBCs and WBCs and decreases fibrinogen concentration, platelet adhesiveness, and blood viscosity
- Supervised exercise program: 30-45 min/day, @least 3x/week for minimum 3 months. Can be walking or cycling
- Adjust caloric intake so ideal body weight achieved/maintained
- Diet: high in fruits, vegetables, and whole grains. Low in cholesterol, saturated fats, and salt
Patients taking antiplatelet agents, NSAIDs, or anticoagulants (warfarin) should consult HCP before taking?
Any dietary or herbal supplements, because of potential interactions and bleeding risks
Critical limb ischemia
- Chronic ischemic rest pain lasting more than 2 weeks, arterial leg ulcers or gangrene of the leg as a result of PAD
- Management goals: protecting extremity from trauma, decreasing ischemic pain, preventing/controlling infection, maximizing perfusion. Inspect, cleanse, and lubricate both feet to prevent cracking of the skin and infection
PAD: Interventional radiology catheter-based procedures are alternatives to open surgical approaches for Tx of lower extremity PAD
1) Percutaneous transluminal angiogplasty: catheter w/cylindric balloon at tip. End of catheter advanced to stenotic (narrowing) area of artery. Balloon is inflated, compressing atherosclerotic intimal linging
2) Stents: expandable metallic devices that keep artery open after balloon angioplasty. May be covered w/Dacron or a drug-eluting agent to reduce restenosis by limiting amount of new tissue growth into stent
3) Atherectomy: removes obstructing plaque. Directional atherectomy device uses high-speed cutting disk that cuts long strips atheroma. Laser atherectomy uses UV energy to break apart atheroma
4) Peripheral arterial bypass operation w/autogenous (native) vein or synthetic graft material to bypass or carry blood around the lesion
5) Endarterectomy (opening artery and removing obstructing plaque) and patch graft angioplasty (opening artery, removing plaque, and sewing a patch to the opening to widen the lumen)
6) Amputation required if tissue necrosis is extensive, gangrene or osteomyelitis, or other major arteries are occluded, precluding possibility of successful surgery
PAD Goals
-Patient w/lower extremity PAD will have adequate tissue perfusion, relief of pain, increased exercise tolerance, and intact, healthy skin on extremities
PAD Nursing interventions:
After surgical or radiologic intervention what should the nurse do?
Check the operative extremity every 15 minutes initially then hourly for color, temp. cap refill time, presence of peripheral pulses or a change in the doppler sound over a pulse. Immediately contact HCP