Study Guide Flashcards
Main SE of magnesium antacids
Diarrhea
What med class stimulates receptors on osteoblasts - can lead to bone breakdown?
SERMS- Tamoxifen, Raloxifene (Evista) , and Clomiphene (clomid)
What formulation of OCP has no androgenic activity?
Possible AE?
Drospirenone
- monitor for hyperkalemia
Retain water to increase intraluminal pressure
Magnesium preps, NaPhos, lactulose, glycerin, sorbitol
osmotics
Symptomatic treatment of hyperthyroidism
Blocks hyperadrenergic effects of thyroid excess
Blocks peripheral conversion of T4 to T3
β-blockers
Tx for IBS
MOA: stimulates intestinal fluid secretion and transit
Linaclotide (Linzess)
Main SE od calcium antacids
constipation
GLP-1 receptor antagonist
avoid use in pts with medullary thyroid cancer
Liraglutide
why can NSAIDS penetrate gastric cells
inhibit cox enzymes -> decrease in PGE2 -> increased gastric acid -> decreased bicarb, blood flow & mucus production
TX of vasomotor sxs of menopause, SIgnificant 1st pass metabolism-> increased binding of globulins, TGs, HDL, clotting factors
Oral Estrogen
Proposed uses of uterotonics
To empty Uterus- labor/ terminate pregnancy
Stop Bleeding- Immediately Postpartum/ late postpartum hemorrhage
Subinvolution- reduction of uterus to its normal size after childbirth
Important teaching info for pt on a G-CSF like Filgrastim (Neupogen)
will reduce risk of infection but they can have significant bone pain (bone marrow is trying to make new cells)
Phosphate binding to Ca
decreased GI absorption and plasma Ca level, increased PTH synthesis/ secretion is caused by what and then leads to what?
Hyperphosphatemia
… Hyperparathyroidism
When renal function is compromised either experimentally or by disease, there is a compensatory enlargement of the remaining nephrons and an increased rate of filtration per nephron. To remain in balance, the phosphate excretion per nephron must also increase.
As renal function progressively declines, increasingly higher levels of PTH are needed to maintain phosphate homeostasis
H2 Antagonists - prevents activation of proton pump by inhibiting activation of H2 receptors in gut= suppression of gastric secretions
Cimetidine, Nizatidine, Ranidatinie, Famotidine
Topical injury from NSAID use
Iron trapping- un-ionized goes to facilitation of transport across membrane in acid stomach lumen…
w/ in the cells ionized NSAIDs trap molecules = cellular damage (cant get out)
Preferred in practice for hyperthyroidism
Longer ½ life, once daily dosing
More potent than PTU - less frequent serious AEs
Methimazole (Tapazole)
Type of therapy that Targets a specific gene or protein on a cancerous cell
Targeted Therapy
Tx for IBS.
MOA: locally active Cl- channel activator that enhances Cl- rich intestinal fluid secretion
Lubiprostone (amitiza)
Why are hormone drug levels are less variable with the patch and vaginal ring?
more continuous absorption
Docusate
Retains water to soften stools
For hypothyroidism … Why not give T3 (Cytomel)?
Better to have a reservoir of T4 (prodrug) to normalize metabolism over a wide range of conditions.
Half-life of T3 is shorter (1 day).
Potential benefits of Oral contraceptives
Potential benefits of Oral contraceptives
used for colonoscopy preps
(osmotics) and saline laxatives
How do Dilantin, Griseofulvin, and Rifampin interact with OCPs?
induce metabolism of OCP- need backup!
Oral Phosphate Binder:
Binds to dietary phosphate, inhibiting its absorption
Not absorbed
Sevelamer (Renagel, Renvela)
What happens when SERMS activate receptors on osteoblasts ?
leads to bone anabolism
what’s the goal range of Hgb for a pt on erythropoietin?
Don’t try and get them in a normal range
- try for 10-12 -
if you push to high there is a greater risk of CV events
why can there be compliance issues with Sucracate
Large tablets and frequent administration
Oral Phosphate Binder: Binds to dietary phosphate, inhibiting its absorption
Dose with meals
Calcium carbonate/calcium Acetate
Contraindicated in Pregnancy - for prevention of NSAID induced ulcers
Misoprostol
This drug class can help to prevent and/or treat neutropenia associated with chemotherapy
Granulocyte-colony stimulating factors (G-CSF) ex. Filgrastim (Neupogen)
How do OCPs interact with corticosteroids?
OCPs potentiate corticosteroids - may need lower dose
Counseling pts for pts with GERD
avoid caffeine (increases acid secretion) avoid alcohol (can have direct toxic effect on the mucosa) stop smoking (decreased production of duodenal bicarb and decreased blood flow decrease ulcer healing) avoid NSAIDs
What to counsel pts taking topical testosterone gel/ patch?
caution w/ transfer to children or pets - kids can develop premature pubic hair, increased libido, aggressive behavior
Opium derivatives
ex. Paregoric/ tincture of opium
Inhibits peristalsis and diarrhea
Loperamide (imodium) AE/ CI
AE: abdominal pain, n/v, bloating, QT prolongation
CI: less than 2 years old-> fetal paralytic ileus, fever, ecoli, salmonella, campylobacter infections
Drugs That Alter Thyroid Status
Amiodarone
Lithium
Metoclopramide (Reglan)
AEs of Cimetidine (Tagamet) - H2 antagonists
potential for diarrhea, headache, muscle pain, constipation, fatigue, confusion
2nd most effective. inhibit CYP enzymes a
decrease elimination of some drugs
H2 Antagonists
Cimetidine, Nizatidine, Ranidatinie, Famotidine
SERM, Inhibits growth of estrogen dependent (ER+) breast tumors, agonist activity in bones can delay or prevent osteoporosis, does not stimulate endometrium
Raloxifene (Evista)
Not caused by H. Pylori, esophageal mucosa damaged by reflux of low PH material into lower esophagus
GERD
Uterotonic - Induces labor by promoting contractions, administered IV*, use w/ caution in cardiac/ renal disease, PIH
Oxytocin (pitocin)
why give colloidal bismuth to pt with H.Pylori and PUD?
coating agent used in PUD - inhibits growth of H. Pylori
increases release of norepi and dopamine from nerve terminals in addition to inhibiting their reuptake
avoid using with MAOIs
avoid abrupt withdrawal
Phentermine
Continue this drug for 1-2 weeks for GI to determine effectiveness
Esomeprazole (Nexium)
Lightheadedness, dizziness, sedation, nausea/ vomiting, euphoria, constipation,pruritus
drug dependence if used consistently
Side effects of tincture of opium
*Potential drug interactions via binding to drugs
AE: constipation
Sucralfate
How does Plan B work? AEs?
interferes with ovulation, fertilization, egg transport, and/ or implantation
ineffective after implantation
Nausea and vomiting
what is usually the culprit to acne?
Progestin
Androgen Receptor Antagonist (2)
Flutamide, Bicalutamide
non-competitive irreversible antagonist. shuts down acid activity by working on potassium hydrogen ATPase pump
Omeprazole (prilosec)
TX of vasomotor sxs of menopause, caution w/ transfer to children/ pets
Topical Estrogen
Goal of chemo treatment
want to give the highest dose of chemo you can with least amount of side effects
Impedes growth of H. pylori,
AE: constipation
Colloidal Bismuth
Treatment goals of PUD
decrease gastric acidity,
enhance mucosal defenses, eliminate H. Pylori,
Advise pt to quit smoking*
Who could benefit from progestin only contraceptives?
anyone who would benefit from avoiding estrogen- lupus sickle cell, cardiovascular disease, migraines, breastfeeding, VTE