Cancer

Question 1

Targets rapidly dividing cells

Dose limiting toxicities related to cell damage (ex. Bone marrow suppression)

Answer 1

Cytotoxic Therapy

Question 2

Targets a specific gene or protein on a cancerous cell

Toxicities assc. w/ the specific target of the drug

Answer 2

Targeted Therapy

Question 3

Activates immune system to treat cancer

Immune-mediated toxicities

Answer 3

Immunotherapy

Question 4

Non-specific forms of cytotoxic chemo

Answer 4

Radiation & Nitrosoureas

Question 5

non-specific: Carmustine, Lomustine, Semustine

Answer 5

Nitrosoureas

Question 6

DNA Intercalators and Cross Linkers - Alkylating Agents:

Answer 6

nitrogen mustards, cisplatin, carboplatin

Question 7

DNA Intercalators and Cross Linkers - Antitumor Antibiotics

Answer 7

Anthracyclines, dactinomycin

Question 8

Targeted therapy: target protein on outside of the cell

Answer 8

Monoclonal Antibodies

Question 9

Targeted therapy- intracellular target to shut down some cellular pathway

Answer 9

Tyrosine Kinase Inhibitors (TKIs)