Study as I go Flashcards

1
Q

Penton fibers?

A

Adenoviridae

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2
Q

Penton fibers cause what?

A

Hemagglutination of RBCs

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3
Q

How are adenoviruses released inside the host?

A

Cell lysis

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4
Q

Infectious Canine Hepatitis?

A

Canine Adenovirus 1

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5
Q

Why is Infectious Canine Hepatitis so infectious?

A

Shed in urine for 6 months

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6
Q

Pathognomonic characteristic of early Infectious Canine Hepatitis?

A

Corneal Edema/Blue eye

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7
Q

Kennel Cough/Infectious Tracheobronchitis

A

CAV-2

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8
Q

What breed is most susceptible to Equine Adenovirus?

A

Arabian Foals

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9
Q

Outcome of Equine adenovirus?

A

Bronchitis and Pneumonia

Death before 3m

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10
Q

How does retroviridae spread in the host?

A

Type 3

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11
Q

Bovine Leukemia

A

Deltaretrovirus

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12
Q

What cell does bovine leukemia target?

A

B lymphocytes

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13
Q

Important proteins for Bovine Leukemia?

A

gp51

p24 (Major Core)

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14
Q

Number one cause of carcass condemnation in cattle?

A

Bovine Leukemia

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15
Q

FeLV?

A

Gammaretrovirus

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16
Q

Important protein in FeLV

A

p27

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17
Q

Target cells of FeLV?

A

T and B

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18
Q

Horizontally transmitted FeLV?

A

FeLV-A

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19
Q

Cats with that FeLV have a higher risk of tumors?

A

A and B

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20
Q

How do cats get FeLV-C?

A

mutation

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21
Q

How soon after having an FeLV + cat can a new one be introduced to the home?

A

3-4w

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22
Q

Antigen present on all membranes of cells transformed by FeLV and FeSV?

A

FOCMA

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23
Q

Recombination of FeLVA and host proto-oncogenes?

A

FeSV

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24
Q

Cause of fibrosarcomas in cats?

A

FeSV

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25
Q

Avian leukosis

A

Alpharetrovirus

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26
Q

What birds are affected by avian leukosis?

A

Chickens only

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27
Q

Target cell of avian leukosis?

A

B

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28
Q

Thick leg in birds?

A

Osteoporosis from avian leukosis

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29
Q

How can you differentiate Avian Leukosis from Marek’s Dz?

A

No nerve or ocular involvement in AL

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30
Q

FIV?

A

Feline lentivirus

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31
Q

How is FIV transmitted?

A

Bites, Milk, TP

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32
Q

What cell does FIV target?

A

CD4

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33
Q

Important antigen in FIV?

A

p24

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34
Q

Retrovirus with no cross protection between serotypes?

A

FIV

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35
Q

Equine Infectious Anemia/Swamp Fever

A

Equine lentivirus

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36
Q

Reportable retrovirus?

A

Equine lentivirus

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37
Q

Vector of Equine lentivirus?

A

Tabanids (mechanical)

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38
Q

Test of Equine lentivirus?

A

Coggins test

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39
Q

Coggins test is for what protein?

A

p26

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40
Q

Caprine Arthritis Encephalomyelitis

A

Caprine lentivirus

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41
Q

Most important goat disease in the US?

A

Caprine lentivirus

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42
Q

Big knee?

A

Caprine lentivirus

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43
Q

Hard bag?

A

Mastitis from caprine lentivirus and ovine lentivirus

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44
Q

Can colostrum be used from CAEV+ goats?

A

Yes, pasturize

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45
Q

Maedi-visna

A

Ovine lentivirus

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46
Q

Maedi?

A

Lungs

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47
Q

Visna?

A

Brain

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48
Q

Incubation period for ovine lentivirus?

A

up to 9 years!!

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49
Q

Symptom of Maedi?

A

Pneumonia

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50
Q

Symptom of Visna?

A

CNS, knuckling of fetlock

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51
Q

Bullet shaped virus?

A

Rhabdo

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52
Q

Rabies?

A

lyssavirus

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53
Q

vesicular stomatitits

A

vesiculovirus

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54
Q

defecting interfering particles are found in what virus?

A

rhabdo

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55
Q

most lethal infectious disease?

A

rabies

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56
Q

which rabies genotype is the classic one?

A

Genotype 1

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57
Q

What species perpetuates cattle rabies?

A

Skunks

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58
Q

What species perpetuates human and non-cattle rabies?

A

Vampire Bats

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59
Q

How does Rabies reach the brain?

A

Centripetal progress

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60
Q

Furious form of rabies replication?

A

Limbic system

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61
Q

Dumb form of rabies replication?

A

Neocortex

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62
Q

How does rabies reach the salivary glands?

A

Centrifugal progress

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63
Q

Why do animals die from rabies?

A

Respiratory failure

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64
Q

Which species has viremia and a carrier state for vesicular stomatitis?

A

Pigs

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65
Q

What disease looks just like vesicular stomatitis?

A

Foot and mouth

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66
Q

Characteristic clinical feature of vesicular stomatitis?

A

Profuse salivation

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67
Q

Immunity for vesicular stomatitis?

A

Short lived

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68
Q

3 day sickness?

A

Bovine ephemerovirus

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69
Q

Vector of bovine ephemerovirus?

A

Mosquitos

Culicoides

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70
Q

Foot and mouth disease?

A

Apthovirus

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71
Q

Avian encephalomyelitis

A

Avian tremovirus

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72
Q

Encephalomyocarditis

A

Cardiovirus

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73
Q

What species are affected by foot and mouth disease?

A

All cloven hoofed animals

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74
Q

How long are cattle carriers for foot and mouth?

A

2yr

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75
Q

How long are sheep carriers for foot and mouth?

A

6m

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76
Q

What animal is not a carrier for foot and mouth?

A

Pigs

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77
Q

When does shedding of foot and mouth begin?

A

24hr before clinical signs

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78
Q

Amplifying host for foot and mouth?

A

Swine

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79
Q

Tiger heart?

A

foot and mouth

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80
Q

How does foot and mouth cause abortion?

A

Fever! Doesn’t cross placenta

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81
Q

Key clinical sign for foot and mouth?

A

profuse salivation

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82
Q

How is foot and mouth transmitted?

A

Aerosol

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83
Q

What species are affected by encephalomyocarditis?

A

Piglets

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84
Q

Reservoir for encephalomyocarditis?

A

Rodents

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85
Q

Clinical feature of encephalomyocarditis?

A

SMEDI

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86
Q

Pathognomonic for encephalomyocarditis?

A

Myocardial infarcts and necrosis

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87
Q

Is vesicular stomatitis more often transmitted by mechanical or biological?

A

Mechanical

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88
Q

Reportable Rhabdoviridaes?

A

Rabies, Vesicular Stomatitis, Bovine Ephemeral Fever (so ALL!)

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89
Q

Why are horse owners cautioned about vaccinated for vesicular stomatitis?

A

Can’t differentiate vaccine from natural exposure

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90
Q

Zoonotic Rhabdos?

A

Rabies and Vesicular Stomatitis

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91
Q

Which rhabdo does not have cross protection?

A

Vesicular Stomatitis

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92
Q

What rhabdo is not in NA?

A

Bovine ephemeral fever

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93
Q

Are picornas stable?

A

In mucus, feces

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94
Q

Where is Foot and Mouth disease not found?

A

NA, CA, Oceania, Carib

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95
Q

What species is genetically resistant to FMD?

A

Horses

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96
Q

Can animals be reinfected with FMD?

A

Yes, no cross protection

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97
Q

Is FMD stable?

A

Very! 2-3 weeks! (not in carcass though, disinfectants work)

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98
Q

Transmission of FMD?

A

Inhalation, Uncooked meat

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99
Q

Why is FMD so worrisome for transportation?

A

Asymptomatic carriers

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100
Q

Reportable Picorna viruses?

A

FMD

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101
Q

What birds are most often affected by avian encephalomyelitis?

A

Chicks

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102
Q

What protein in Paramyxo neutralizes antibodies?

A

H

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103
Q

What protein in Paramyxo destroys mucin inhibitors?

A

N

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104
Q

What protein in Paramyxo helps with Type 3 spread?

A

F

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105
Q

Most important avian disease?

A

Newcastle

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106
Q

Which paramyxos have H and N proteins?

A

BPI-3, Newcastle

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107
Q

Which protein does canine distemper not have?

A

N

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108
Q

Inclusion bodies in Paramyxo?

A

Red, IN/IC

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109
Q

Shipping fever associated paramyxo viruses?

A

Bovine Parainfluenza

Bovine Respiratory Syncytial Disease

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110
Q

Newcastle Disease?

A

Avian paramyxovirus 1

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111
Q

Avirulent strain of newcastle disease?

A

lentogenic

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112
Q

What enzyme does the lentogenic newcastle use?

A

Trypsin

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113
Q

Virulent strains of ND use what enzyme?

A

endoprotease

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114
Q

Moderately virulent ND strain?

A

Mesogenic

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115
Q

Highly virulent ND strain?

A

Velogenic

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116
Q

When is ND shed?

A

before during and after symptoms!

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117
Q

What form of ND affects the intestines rather than the respiratory tract?

A

Viscerotropic Velogenic ND

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118
Q

Which forms of ND have high mortality?

A

Viscerotropic and Neurotropic Velogenic

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119
Q

Kennel cough paramyxo?

A

Canine Parainfluenza Virus 5

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120
Q

Canine distemper?

A

Canine morbillibirus

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121
Q

What tissue does canine distemper target?

A

Neurotropic

122
Q

The human and canine morbillivirus vaccine share what protein antigen?

A

F

123
Q

Peste des Petits

A

Caprine morbillivirus

124
Q

Symptoms of Peste des petits

A

mouth erosions, stomatitis, diarrhea, pneumonia

125
Q

When is Peste des Petits shed?

A

1-2 days before

126
Q

Reportable paramyxo?

A

Peste des Petits, Newcastle

127
Q

Zoonotic paramyxo?

A

Canine Parainfluenza, Newcastle

128
Q

Bovine respiratory syncytial disease?

A

bovine pneumovirus

129
Q

Short lived immunity paramyxo?

A

bovine respiratory syncytial disease

130
Q

Pathogenesis of bovine respiratory syncytial disease

A

loss of ciliated epithelium

131
Q

Which paramyxo can cause abortion?

A

Peste de Petits

132
Q

The hemagglutinin protein in Orthomyxo has what function?

A

Binds sialic acid receptors for attacment

133
Q

The neuraminidase protein in Orthomyxo has what function?

A

Cleave sialic acid to release virions

134
Q

What is unique about Orthomyxo’s replication process?

A

Cap snatching

135
Q

What is cap snatching?

A

cleave 5’ methyl-g from RNA to get transcription primer

136
Q

Equine influenza etiology?

A

A/H3N8

137
Q

Canine influenza etiologic agent?

A

A/H3N8

138
Q

How are equine influenza and canine influenza related?

A

Canine is a mutation of Equine

139
Q

When is canine influenza shed?

A

During IP and 1 week after

140
Q

What does canine influenza present like?

A

Kennel Cough

141
Q

What is unique about the Canine Influenza vaccine?

A

Doesn’t prevent- reduces severity

142
Q

Which influenza does not have a carrier sate?

A

Equine

143
Q

Swine Influenza etiologic agent?

A

A/H1N1-3 (1 most common)

144
Q

Pigs are predisposed to swine flu due to what infection?

A

Ascaris suum

145
Q

How do you prevent swine flu?

A

Avoid carrier pigs

146
Q

Which strain of avian influenza infects chickens most?

A

H5N1

147
Q

Which strain of avian influenza infects turkeys?

A

H5N9

148
Q

Avian influenza common name?

A

Fowl plague

149
Q

Which bird is most often affected by fowl plague?

A

Turkeys

150
Q

What orthomyxo can affect the GIT?

A

Avian

151
Q

What orthomyxo can affect the CNS?

A

Avian

152
Q

What orthomyxo can cause abortion due to fever?

A

Equine

153
Q

How do you prevent avian flu?

A

Sentinel birds

154
Q

African horse sickness

A

Orbivirus

155
Q

Bluetongue virus

A

Orbivirus

156
Q

Avian reovirus

A

orthoreovirus

157
Q

Most common cause of diarrhea in young animals?

A

Rotavirus

158
Q

What species does blue tongue affect?

A

sheep, deer

159
Q

Reportable Reoviruses?

A

Blue Tongue

African Horse Sickness

160
Q

Vector of blue tongue?

A

Culicoides

  • variipnnsis
  • SE insignis
161
Q

Other than arthropod vector, how can blue tongue be spread?

A

TP, Venereal

162
Q

Which serotype of blue tongue affects the southeast?

A

2

163
Q

What serotypes of blue tongue are in the US?

A

10, 11, 13, 17, (2)

164
Q

Vector of african horse sickness?

A

culicoides

165
Q

Symptoms of african horse sickness?

A

frothing, pulmonary edema, hydropericardium, facial edema, petechiae

166
Q

Acute pulmonary horse sickness?

A

Dunkop

167
Q

Subacute cardiac horse sickness?

A

Dikkop

168
Q

Rotavirus outer capsid proteins?

A

VP7, VP4

169
Q

VP7 classifies what for Rotavirus?

A

G Genotypes

170
Q

VP4 classifies what for Rotavirus?

A

P Genotypes, P Serotypes

171
Q

How stable is rotavirus in the environment?

A

Very-30d

172
Q

Where does Rotavirus replicate within the host

A

mature enterocytes of SI villi

173
Q

What species have a Rotavirus vaccine?

A

Equine, Bovine

174
Q

Viral arthritis and tenozynovitis in chickens

A

Avian reovirus

175
Q

Important capsid protein for corona?

A

Spike

176
Q

Transmissible Gastroenteritis in Pigs?

A

Porcine Coronavirus

177
Q

Which form of TGE occurs more often in winter?

A

Epidemic

178
Q

Which form of TGE affects susceptible herds rather than partially immune?

A

Epidemic

179
Q

Which form of TGE affects partially immune herds?

A

Endemic

180
Q

Which form of TGE is more severe?

A

Epidemic

181
Q

Major cause of mortality in the pigs in the US?

A

TGE

182
Q

What does TGE do to villi?

A

Atrophy-> malabsorption

183
Q

Who do you vaccinate for TGE?

A

Pregnant Sows

Neonates

184
Q

Porcine Epidemic Diarrhea?

A

Coronavirus

185
Q

Where is PED problematic?

A

Asia

186
Q

How are PED and TGE related?

A

They aren’t!
PED- Group 1b
TGE- Group 1a

187
Q

Vomiting and Wasting disease in pigs?

A

Porcine Hemagglutinating Encephalomyelitis

188
Q

Porcine Hemagglutinating Encephalomyelitis?

A

Coronavirus

189
Q

How is Porcine Hemagglutinating Encephalomyelitis transmitted?

A

Aerosol, Contact with secretions

190
Q

Why is Porcine Hemagglutinating Encephalomyelitis called wasting disease?

A

Encephalomyelitis leads to vomiting and malnutrition

191
Q

Bovine coronavirus occurs at what time of year?

A

Winter

192
Q

Where does bovine coronavirus replicate?

A

SI and LI

193
Q

How does bovine corona affect villi?

A

Atrophy-> malabsorption

194
Q

Other than diarrhea, what else can bovine corona cause?

A

Respiratory issues

195
Q

When do you vaccinate cows for bovine corona?

A

Before each calving

196
Q

Winter dysentery in cows?

A

coronavirus

197
Q

What age group is affected by winter dysentery?

A

Adult cows

198
Q

Other than diarrhea, what else can winter dysentery cause?

A

hemorrhage, hyperemia of colon

199
Q

FIP?

A

feline coronavirus

200
Q

How is FIP transmitted?

A

fecal oral, inhalation, TP

201
Q

What percent of cats infected with FCoV get FIP?

A

1-3%

202
Q

What percent of cats infected with FCoV are resistant?

A

5-10%

203
Q

What percent of cats infected with FCoV get diarrhea?

A

70%

204
Q

What percent of cats infected with FCoV are persistent carriers?

A

5-10%

205
Q

A strong CMI response will have what effect on FIP?

A

Prevent FIP

206
Q

A weak CMI response and strong humoral response will have what effect on FIP?

A

Effusive/Wet Form

207
Q

An intermediate immune response will have what effect on FIP?

A

Non-effusive/Dry Form

208
Q

Clinical signs of effusive FIP?

A

distension, peritonitis, ascites, pyogranulomas

209
Q

Clinical signs of non-effusive FIP?

A

uveitis, granulomatous inflamation, pyogranulomas, meningoencephalitis

210
Q

What test is used for FIP?

A

Rivalta test

211
Q

Is there a vaccine for FIP?

A

Yes, but not recommended

212
Q

Avian Infectious Bronchitis?

A

coronairus

213
Q

Specific cross protection in avian infectious bronchitis?

A

Protectotypes

214
Q

Respiratory strain of avian infectious bronchitis?

A

Mass, Conn, Ark, Ga

215
Q

Nephrotropic strain of avian infectious bronchitis?

A

T, Gray, Holte

216
Q

Vaccine used for meat type chickens for avian infectious bronchitis?

A

Live

217
Q

Vaccine used for layers and breeders for avian infectious bronchitis?

A

Inactivated

218
Q

Breda virus?

A

Bovine torovirus

219
Q

What organ does bovine torovirus affect?

A

SI: lower half of villi, crypts

220
Q

Most fatal togavirus?

A

EEEV

221
Q

Vector of WEEV?

A

Culex tarsalis

222
Q

Vector of EEEV?

A

Culiseta melanura

223
Q

Vector of enzootic VEEV?

A

Culex

224
Q

What seasons does EEEV occur?

A

Late summer/early fall

225
Q

What weather benefits EEEV?

A

Heavy rainfall

226
Q

Dead end host of EEEV?

A

horses and humans

227
Q

How is WEEV related to EEEV?

A

recombination of EEEV

228
Q

Dead end host of WEEV?

A

horses, humans

229
Q

Epizootic strains of VEEV?

A

1-A/B/C

230
Q

Enzootic strains of VEEV?

A

1-D/E/F, 2-6

231
Q

Highly virulent strain of VEEV?

A

epizootic

232
Q

Non virulent strain of VEEV?

A

Enzootic

233
Q

Primary vector of Enzootic VEEV?

A

Culex

234
Q

Dead end host of enzootic VEEV?

A

horse, human

235
Q

Dead end host of epizootic VEEV?

A

humans

236
Q

Amplifying host of epizootic VEEV?

A

Horse

237
Q

Horse vaccines for EEV?

A

EEEV, WEEV-inactivated

VEEV- tissue culture attenuated

238
Q

Human vaccines for EEV?

A

VEEV-workers only, not licensed

239
Q

Flaviviridae with veterinary importance?

A

Pestivirus

240
Q

Difference between ncp and cp forms of BVD?

A

Cleavage of NS2-3

241
Q

Mucosal form of BVD?

A

cp

242
Q

Bovine Viral Diarrhea?

A

Pestivirus

243
Q

What protein is inserted between the NS2-3 sequence in BVD?

A

Ubiquitin

244
Q

Which type of BVD is more common?

A

Type 1

245
Q

Relationship between BVD 1/2?

A

Antigenically distinct

246
Q

Relationship between cp and noncp BVD?

A

Antigenically related

247
Q

Pregnant cows infected with BVD at 2-4 months give birth to what?

A

PI calves

248
Q

Pregnant cows infected with BVD at 1 month give birth to what?

A

They don’t! embryo death

249
Q

Pregnant cows infected with BVD at 5-9 months give birth to what?

A

Normal, deformed, or dead calves

250
Q

Why do PI calves not have antibody response?

A

BVD inhibits IFN Type 1

251
Q

Source of BVD infection?

A

Fluids

252
Q

Non-pregnant cows get what form of BVD?

A

Thrombocytopenia and Hemorrhagic syndrome, diarrhea in calves too

253
Q

Do calves with BVD antibodies mean they are PI?

A

Possibly, test for antigen

254
Q

Do calves with BVD with antigen mean they are PI?

A

Possibly, could just be active infection!

255
Q

How do you test for BVD?

A

Ear punch

256
Q

How are African Swine Fever and Classical Swine Fever distinguished?

A

They aren’t!

257
Q

Primary site of CSF invasion?

A

Tonsil

258
Q

Symptoms of CSF?

A

huddling, hyperemia, cyanosis of ears, diarrhea

259
Q

Pathognomonic for CSF?

A

Turkey Egg Kidneys

260
Q

Why should you use the DIVA CSF vaccine?

A

Can distinguish from active infection

261
Q

What type of host are horses for West Nile?

A

Incidental host

262
Q

How is Louping Ill spread?

A

Ticks-ixodes ricinus

263
Q

Species affected by louping ill?

A

turkeys, sheep

264
Q

Viruses caused by pestivirus?

A

BVD
CSF
West Nile
Louping Ill

265
Q

Cup shaped depression virus?

A

Caliciviridae

266
Q

Important genus of Caliciviridae in vet med?

A

Vesivirus

267
Q

Vesicular exanthema of pigs?

A

Porcine calicivirus

268
Q

Most common symptoms of calicivirus in cats?

A

oral and respiratory issues

269
Q

Calicivirus with carrier state?

A

Cats

270
Q

How is calicivirus transmitted?

A

Conjunctiva
Inhalation
Ingestion

271
Q

Where does calicivirus replicate within the host?

A

Oral and Respiratory tissues

272
Q

Most common lesion from calicivirus?

A

Ulcers

273
Q

Limping syndrome in cats?

A

Feline calicivirus

274
Q

Cats vaccinated for calicivirus can still get this form?

A

FCV-VSD (virulent systemic disease)

275
Q

Symptoms of FCV-VSD other than normal FCV symptoms?

A
Facial Edema
Foot Pad Sloughing
Pneumonia
Liver, Spleen, Pancreatic Necrosis
Vascular Injury
276
Q

Immunity with FCV?

A

Not lifelong, vaccinate recovered animals!

277
Q

Vesicular Exanthema of Swine can be confused with what other diseases?

A

Foot and Mouth
Vesicular Stomatitis
Swine Vesicular Disease

278
Q

Is vesicular exanthema of swine in the US?

A

Not anymore!

279
Q

How is vesicular exanthema of swine transmitted?

A

Direct Contact

Pork Scraps

280
Q

San Miguel Sea Lion Virus?

A

Calicivirus (unspecified)

281
Q

Important birnaviridae we studied?

A

Avibirnavirus

282
Q

Infectious Bursal Disease?

A

Avibirnavirus

283
Q

Gumbo disease?

A

Avibirnavirus

284
Q

What cells are affected by avibirnavirus?

A

B cells

285
Q

Which serotype of infectious burial disease is pathogenic?

A

IBDV-1

286
Q

What species is affected by IBVD?

A

Young chickens

287
Q

How resistant is IBDV?

A

Very! up to 52 days in environment!

288
Q

Initial site of replication of IBDV?

A

Gut macrophages and lymph

289
Q

How does IBDV reach the BF?

A

Viremia

290
Q

Does IBDV spread beyond the BF?

A

Yes! Secondary viremia to other lymph tissues

291
Q

Why is IBDV often fatal?

A

Cytokine storm

292
Q

Symptoms of IBDV?

A

ruffled
diarrhea
swollen BF

293
Q

Which vaccine can be given to chicks for IBDV before the maternal ABs wear away?

A

Hot Vaccine

Intermediate Vaccine

294
Q

Vaccination for IBDV in the egg?

A

Live recombinant vaccine

295
Q

Viruses on this test that replicate in the cytoplasm?

A

Reoviridae

Orthomyxo (both)

296
Q

Double Stranded viruses on this test?

A

Adenoviridae
Reoviridae
Birnaviridae

297
Q

Segmented viruses on this test?

A

Reo
Birna
Ortho

298
Q

Helical viruses on this test?

A

Ortho
Corona
Rhabdo
Paramyxo

299
Q

Viruses with inclusion bodies on this test?

A

Adeno (N)
Rhabdo (Negri)
Paramyxo (N/C)

300
Q

Enveloped viruses on this test?

A

Calici
Reo
Birna

301
Q

Tumor causing viruses on this test?

A

Retro

Adeno