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Clinical Chemistry: Hematology > Study Aid Test Questions > Flashcards

Study Aid Test Questions Flashcards

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1
Q

Sites of hemopoiesis (conception-adult)

A

0-2 months: blood cells formed in the yolk sac;
2-7 months: liver and spleen
5-9 months: bone marrow
Infant-childhood: ~50% marrow
Adult: Skull, vertebral column (ribs and sternum), sacrum, pelvis, proximal femurs

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2
Q

Cytoskeleton composed of what in erythrocyte?

A

Alpha and Beta spectrin

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3
Q

Pokiliocytes: mean, reflect, suggest what is taking place?

A

Suggest Hemopoiesis

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4
Q

Normal RBC count

A

Overall: 3.6-5.4

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5
Q

Cause for primary erythrocytosis?

A

Polycythemia vera: hyperplasia within marrow, but don’t know why

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6
Q

Explain what increase in RBC count suggests?

A

Primary: Polycythemia vera

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7
Q

Cause for relative erythrocytosis

A

Dehydration, overuse of diuretics

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8
Q

Abnormal erythrocyte sites: term used that cells have abnormal sizes

A

Anisocytosis: RBC is of unequal size; suggests anemia

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9
Q

Most logical/ reasonable explanation for erythropenia?

A

Anemia: especially patients with RH

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10
Q

Given reticulocyte count of 5% suggests what?

A

Hemolytic anemia

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11
Q

Normal reticulocyte index

A

1

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12
Q

Normal hematocrit

A

Overall: 36-52

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13
Q

Packed cell volume of 30%

A

Low for both M/F –> anemia, leukemia cirrhosis, hyperthyroidism

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14
Q

Increased Hct reflects what?

A

increase in altitude, polycythemia, SEVERE DEHYDRATION, shock

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15
Q

Know normal range of Hb and difference between male and female

A

OVERALL: 12-17.4
Male: 14-17.4 gm%
Female: 12-16 gm%

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16
Q

Lab tests evaluate degree of anisocytosis (not the same size)

A

RDW Tests

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17
Q

Mean corpuscular volume (MCV) level means?

A

100-160: macrocytic anemias, large volume (B12, or folic acid deficiency)

18
Q

What may affect HbA level

A

Nothing, glucose levels?

19
Q

HbH1c levels suggest diabetic patient in different volumes of control?

A 
7% = good controls
10% = fair
13-20% = poor
20
Q

Glycolcilia Hb levels decrease 4%

A

Chronic renal failure since kidney can no longer produce erythropoietin

21
Q

Cause of microcytic normochromic anemia?

A

Renal disease: not producing erythropoietin

22
Q

Features of Plummer-Vinson Syndrome?

A

Koilonychia: spoon shaped nails

23
Q

Labs in early stages of IDA?

A

Increase # of platelets

24
Q

Which anemia has golf ball cells in stain?

A

Alpha-thalacemia (with cresol stain)

25
Q

What are labs for patient with alpha-thalacemia?

A

Microcytic hypochromic

26
Q

Physical and lab features of patient with severe Cooley’s anemia?

A

(PAS doesn’t indicate???) Life threatening, growth failure and growth deformities

27
Q

Causes of alpha-thalacemia?

A

HbH Affinity to O2

28
Q

Anemia that produces hypoplasia or absence of thumbs?

A

Fanconi’s anemia

29
Q

What are labs of patient with severe B12 deficiency?

A

a. Anicytosis, pequiliocytosis
b. Macrocytic and normochromic
c. If B12 serum levels are

30
Q

What are labs of patient with severe folic acid deficient anemia?

A

Macrocytic, normochromic (like B12)

31
Q

Lab tests that screen HbS?

A

Sickledex Solubility prep

32
Q

Abnormal RBC suggest hypospleenism

A

Target cells and giant bodies: spleen cannot handle these morphologies

33
Q

Labs for patient with sickle cell disease?

A

HbS

34
Q

Presence of >3% stab cell in leukocytosis suggests?

A

Shift to the left (neutrophilia)

35
Q

Downey cells

A

Lymphocytes of infections

36
Q

Cause for lymphopenia?

A

Post chemo or radiation therapy or an immunosuppressant

37
Q

What leukemia’s most common for adults?

A

CLL: Chronic Lymphocytic Leukemia (over 50)

38
Q

Leukomoid reaction

A

is not progressive/ permanent

39
Q

ESRs using tubes: if reads 20 mm in 1 hour: suggests?

A

No alteration of plasma proteins

40
Q

Normal value for C-reactive protein?

A

0.7 is the answer on exam

Clinical Chemistry: Hematology (23 decks)

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