Structural, inflammatory cardiac disorders Flashcards
What is infective endocarditis?
And how is it treated?
Infection of endocardial surface of the heart that affects the cardiac valves.
treated with penicillin
Name and describe the two forms of infective endocarditis:
And what are most common bacteria’s that cause it?
1-Subacute form: which affects those with pre-existing valve disease
2- acute form: affects those with healthy valves
Most common bacterial causes: Staphylococcus aureus and streptococcus viridans
What are risk factors for getting infective endocarditis?
Principal risk factors are prior endocarditis, prosthetic valves, acquired valvular disease and cardiac lesions
What are symptoms of infective endocarditis?
Clinical findings can include low-grade fever, chills, fatigue,anorexia.
arthralgias, back pain, abdominal discomfort, headache, petechiae,
Osler’s nodes on the fingertips or toes. Janeways lesion on palms and soles.
Roths spots.
a new murmur or heart failure
Osler’s nodes
Osler’s nodes are painful, red, raised lesions found on the hands and feet.
They are associated with a number of conditions, including infective endocarditis, and are caused by immune complex deposition.
Janeway’s lesions
Janeway lesions are rare, non-tender, small erythematous or haemorrhagic macular, papular or nodular lesions on the palms or soles only a few millimeters in diameter that are associated with infective endocarditis and often indistinguishable from Osler’s nodes.
Roth’s spots
Roth Spots are defined as a white centered retinal hemorrhage and are associated with multiple systemic illnesses, most commonly bacterial endocarditis. …
Though roth spots are usually thought of as pathognomonic for bacterial endocarditis, they can occur in a number of conditions
Pericarditis
What is it and what can cause it?
Inflammation of pericardial sac a.k.a. the pericardium.
Is usually idiopathic but can be caused by various infectIons, MI, tuberculosis, neoplasm or trauma
What are the symptoms of acute pericarditis?
Progressive, severe chest pain that is sharp and pleuritic in nature and worse with deep inspiration and when lying supine.
The pain is relieved by sitting. Pain can be referred to the trapezius muscle.
Hallmark finding is pericardial friction rub.
What are some complications of pericarditis?
and what are some treatments?
Complications include pericardial effusion and cardiac tamponade.
Treatment includes antibiotics, corticosteroids or NSAIDs.
Colchicine may be used for recurrent pericarditis.
Pericardiocentesis is performed for pericardial effusion.
Chronic constrictive pericarditis.What is it?
Results from scarring with consequent loss of elasticity of the pericardial sac.
Begins with initial episode of acute pericarditis followed by fibrous scarring, thickening of the pericardium from calcium deposit and eventual obliteration of the pericardial space.
All of this interferes with the ability of the atria and ventricles to stretch adequately during diastole
What are symptoms of chronic constrictive pericarditis?
And what is treatment?
Symptoms mimic heart failure and cor pulmonale include DOE, peripheral Edema, ascites, fatigue, anorexia, weight loss.
jugular venous distention.
Pericardial knock which is a loud, early diastolic sound.
Treatment is pericardectomy which involves complete resection of the pericardium through median sternotomy with the use of cardio pulmonary bypass.
What is myocarditis and what are some causes?
Focal or diffuse inflammation of the myocardium caused by viruses, bacteria, fungi, radiation therapy, pharmacologic and chemical factors.
Frequently associated with acute pericarditis. Myocarditis result in cardiac dysfunction and has been linked to development of dilated cardiomyopathy.
What are clinical manifestations of myocarditis?
Fever, fatigue, myalgias, pharyngitis, dyspnea, lip and then apathy, nausea and vomiting.
Early cardiac manifestations appear 7 to 10 days after viral infection and include pleuritic chest pain and pericardial friction rub and effusion.
Late cardiac signs relate to heart failure: crackles, jugular venous distention, syncope, peripheral edema and angina.
What are treatments for myocarditis?
Digoxin, diuretics, nitropress, anticoagulation, immunosuppressives.
Oxygen, bed rest, restricted activity.
Intraaortic balloon pump therapy
Complications of myocarditis
Most recover spontaneously.
Some may develop dilated cardiomyopathy. If severe heart failure occurs, may require heart transplant.
Rheumatic Fever
Inflammation of heart involving all layers.
Causes rheumatic heart disease
Rheumatic fever is an inflammatory disease that affects the skin, joints, heart, and central nervous system.
Aschoff bodies
nodules found in the hearts of individuals with rheumatic fever. They result from inflammation in the heart muscle and are characteristic of rheumatic heart disease.
What is rheumatic heart disease
Rheumatic heart disease is when permanent damage is done to the heart valves from rheumatic fever. It results in mitral stenosis or aortic stenosis which is narrowing of those heart valves.
Difference between valvular stenosis and valvular regurgitation
Stenosis is when the valve opening becomes narrow and restricts blood flow.
Prolapse is when a valve slips out of place or the valve flaps (leaflets) do not close properly.
Regurgitation is when blood leaks backward through a valve, sometimes due to prolapse.
What causes mitral valve stenosis?
And what are symptoms?
Caused by rheumatic heart disease, congenital, rheumatoid arthritis or lupus.
Symptoms: DOE, fatigue, palpitations,
loud first heart sound and low rumbling diastolic murmur. Crackles and wheezes from pulmonary edema.