Strongyles 2 Flashcards
You find strongyle-type eggs in a foal less than 6 weeks old. What do you suspect?
The foal probably swallowed ingested mare feces, and the eggs are just passing through the GI tract.
You find strongyle-type eggs in a foal >6wks but <6mo old. What do you suspect?
Likely a small strongyle infection.
Recall that the minimum pre-patent period for large strongyles is 6 months.
You find strongyle-type eggs in a foal older than 6 months. What type of infection do you suspect?
Probably a mixture of large and small strongyles.
Impossible to differentiate between large and small strongyle eggs grossly. To distinguish the two, you can allow the larvae to hatch or run a PCR.
What is the scientific term for a small strongyle infection?
Cyathostomiasis
Which are more susceptible to anthelmintics: large strongyles or small strongyles?
Large strongyles.
Resistance to anthelmintics is an increasing problem in small stronglyes.
Name 3 common genera of small strongyles.
- Cyathostomum*
- Cylicocyclus*
- Cylicostephanus*
Which small strongyle life stage is infective? Describe this stage.
L3
This stage is free-living on vegetation and retains the sheath from the previous molt.
What happens to the L3 cyathostome larva once it is swallowed by the equine host?
Sheds its sheath, burrows into the mucosa, molts to L4 larva.
What factors can contribute to clinical disease in a horse with a small strongyle infection?
Crowding, poor nutrition, poor worming program, etc.
For example, if a horse has bad teeth and is not able to obtain proper nutrition, it is more likely to show signs of disease when infected with small strongyles.
What are the clinical signs associated with a small strongyle infection in horses?
Weight loss or decreased weight of gain
Generalized debility/poor doer
Retention of winter hair coat
May have diarrhea, but not necessarily
How would you diagnose a small strongyle infection
Age
Clinical signs
Large numbers of strongyle-type eggs in the feces
What is larval cyathostomiasis?
Clinical syndrome caused by mass emergence of larvae from their mucosal cysts. Causes a massive insult to the gut wall.
Often seen in spring when large numbers of hypobiotic larvae emerge.
Not seen in every small strongyle infection.
What is a potential concern of quickly killing adult cyathostomes in an equine gut with anthelmintics?
Rapid decline in adult numbers may cause a mass emergence of hypobiotic larvae, resulting in larval cyathostomiasis.
Usually occurs within 2 weeks of treatment.
What are the clinical symptoms associated with larval cyathostomiasis?
Acute onset of fever
Persistent diarrhea (may contain blood and mucus)
Hypoalbuminemia, neutrophilia, hyperglobulinemia
Severe weight loss
Potentially fatal
A horse is showing signs of larval cyathostomiasis. How do you diagnose it?
Unfortunately, this is usually done at necropsy.
Because the disease results from LARVAL emergence, you usually cannot detect eggs in the feces.
How do you treat larval cyathostomiasis?
Anthelmintic:
Moxidectin
Supportive care:
anti-diarrheal drugs
corticosteroids to decrease inflammation
You detect cyathostomes in your horse herd. DEWORM. DEWORM EVERYTHING.
Right?
Chill out, bro.
Strategic deworming should be planned on a farm-by-farm basis.
Take into account which horses are showing signs, sanitation, and husbandry practices.
What are the main goals of SELECTIVE THERAPY in strongyle control?
- Control populations in order to avoid clinical signs (i.e. reduce eggs on the pasture).
- Control/slow the development of resistance.
What husbandry measures can you implement to help control equine strongyles?
Remove vegetation growing in paddocks
Feed dry feed only
Keep horses on a sound nutritional program
Which two major observations is the concept of selective therapy reliant on?
Parasites are unevenly distrubeted (overdispursed)
Stroyngyle egg shedding adult horses is consistent over time
True or False:
If a horse infected with strongyles is a high egg-shedder, it will remain a high egg-shedder over time.
TRUE
Egg shedding over time tends to remain consistent in adult horses.
What are refugia in parasite populations?
Hosts that have been left untreated in order to maintain parasite genes that remain susceptible to anthelmintics.
What happens if you treat an entire population with anthelmintics? Why are refugia important?
Treating an entire population will allow only resistant parasites to survive. Leaving some animals untreated leaves resistance genes in the population.
What is cross-resistance?
Parasites resistant to one drug in an anthelmintic class are usually resistant to all drugs in that class.