Stromal Environment Flashcards
1
Q
Define:
- connective tissue:
- extracellular matrix:
A
- connective tissue: any supporting tissue that lies between other tissues and consists of cells embedded in a relatively large amount of ECM, includes bone cartilage, and loose connective tissue
- extracellular matrix: complex network of polysaccharides and proteins secreted by cells, serves as a structural element in the tissues and also influences their development and physiology
2
Q
What is the function of ECM?
A
- support for cells
- pattern of ECM regulates: polarity, cell division, adhesion, motility
- development: migration, differentiation
- growth factors
- not inert scaffold, active and complex role in regulating cell behaviour
- influences: cell survival, development, migration, proliferation, shae and function
3
Q
What are the cells of the normal stroma?
What are the two ways a tumour can metastasise?
A
Normal stromal cells:
- fibroblasts
- endothelial cells
- inflammatory cells
Tumours can metastasise by blood vessels, or lymph nodes
