Strokes Flashcards
Ddx for Stroke
Intracranial Abscess/Neoplasm
Bell Palsy
Botulism
Encephalitis
Hyperglycemia/Hypoglycemia
Hypertensive urgency/emergency
Psychiatric disorders/conversion disorder
Seizure
Spinal injury
Uremia
Ingestions (eg, ethanol)
What is the most important modifiable risk factor for stroke?
HTN
What are some other modifiable risk factors for a stroke?
Diabetes mellitus
Cardiac disease - Atrial fibrillation, valvular disease, mitral stenosis, and structural anomalies allowing right to left shunting, such as a patent foramen ovale and atrial and ventricular enlargement
Hypercholesterolemia
Transient ischemic attacks (TIAs)
Carotid stenosis
Hyperhomocystinemia
What is an irreversible infarct?
Sustained CBF below 10-12 ml/100g/min leads to rapid (less than 30 min) tissue necrosis
What are the most common etiolgoies of strokes?
What are the most common sources of cardioembolic strokes?
MCA distribution
When will a patient qualify for BOHT IV TPA and mechanical embolectomy
IF the stroke the is a large vessel occlusion (LVO) (i.e. carotid, M1/M2 MCA occlusions, or vertebrobasilar occlusions)
How is mechanical embolectomy accomplished?
Mechanical embolectomy in acute ischemic stroke employs the use of novel endovascular devices to revascularize occluded intracerebral arteries. Devices like the Merci Retiever and other endovascular snares, laser thrombectomy and rheolytic/obliterative microcatheters, intracranial balloon angioplasty and stenting, and intra-arterial and transcranial ultrasound-enhanced chemical thrombolysis are intended to improve tissue rescue and diminish reperfusion hemorrhage while broadening the population eligible for therapy. Patient selection with MRI- and CT-based stroke protocols can detect tissue at risk and may obviate the classic limitations of the stroke therapeutic time window. These devices are being developed and modified at a rapid pace, requiring mounting endovascular expertise, and are being used successfully alone or in conjunction with chemical thrombolysis with relative safety.
What is the timeframe for IV TPA?
4.5 hrs
What is the timeframe for IV mechanical embolectomy?
Up to 8 hrs, preferrably on the angio table 6 hours after the onset.
NOTE: If there is a contraindication to IV TPA in a patient with LVO, they may qualify for embolectomy alone.
Do not forgo the IV TPA in a patient who will have embolectomy unless there is a relative or absolute contraindication to IV TPA, but not mechanical embolectomy
In LVO, IV TPA ( without mechanical embolectomy) is successful in recanalizing the vessel in 10—15% of cases
If you give IV TPA within 3 hours from the time of onset, you need to mention in your dictation that you discussed the possible complications, you do not necessarily need to have then sign a consent
When you give IV TPA in the 3—4&1/2 hours, it a standard of care, you should not forgo it in eligible candidates, however you need to have a signed consent, unless the patinet is unaccompanied & cannot consent
T or F. Patients must be 18+ years old to receive TPA
T.
Newer embolectomy devices-
Stent retrievers
Trevo
Solitaire
What is the the fastest and most effective way of making the initial evaluation of acute stroke patients?
non contrast CT scan of the brain
What is the most sensitive imaging modality for ischemia?
Diffusion weighted imaging probably the most sensitive measure of ischemia.