Stroke imaging and its usefulness in stroke prognosis Flashcards

1
Q

Why is studying stroke recovery important?

A
  1. One of the biggest health problems we have in neurological science
  2. There is a stroke every 5 minutes in the UK
  3. About 1 in 5 people in the UK will have stroke
  4. 4th leading cause of death in the UK
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2
Q

What is the most common neurological cause of disability worldwide?

A

Stroke

1.2 million stroke survivors in the UK

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3
Q

How many people are living with the consequence of acquired brain injury in the UK?

A

3 million people

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4
Q

What is the economic burden in the UK for stroke?

A

Estimated at £26 Billion/year

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5
Q

What is one of the problem across the world for stroke?

A

It is considered as a single incident disease e.g. have stroke and do recovery at home

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6
Q

What is stroke?

A

Long term and chronic progressive disease like Alzheimer’s, Parkinson’s disease

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7
Q

What is the benefit of rehabilitation?

A

Providing patients with tools to maintain their recovery

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8
Q

What is FM-UL score?

A

A measure of motion impairments

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9
Q

What are you looking for in a FM-UL scores?

A

Minimum clinically important differences of about 6 points

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10
Q

What is stroke?

A

Quite heterogenous

Both in terms of location and damage

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11
Q

Why doesn’t the arm work in people that have stroke?

A
  1. Profound scapula instability
  2. Flaccid paralysis [profound weakness]
  3. Sensory loss or neglect of that side of space
  4. Apraxia
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12
Q

What are the new approach for promoting recovery after stroke?

A
  1. Want behavioural changes e.g. arm to move, to be able to speak, memory to be better
  2. Achieve this through a behavioural input
  3. Input will drive the output
  4. The output is behavioural
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13
Q

What are examples of behavioural input?

A
  1. Physiotherapy
  2. Occupational therapy
  3. Neuropsychology
  4. Speech language
  5. Motor training
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14
Q

What are the number of components for the behavioural input?

A
  1. Strength training

2. Training dexterity

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15
Q

What are the number of components for the behavioural output?

A
  1. Impairment
  2. Activity
  3. Participation
  4. Quality of life
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16
Q

What are the input and output relationships going to be modulated by?

A

Brain states e.g. anatomy of damage or plasticity

17
Q

What does the modulation of the input and output relationship lead to?

A

Predictions
Outcome response to therapy

  • Input is therapy
  • Output is the response
  • State is the modulator
18
Q

What do you need to understand about the new approach for promoting recovery?

A
  1. Clinical phenotype

2. Brain scans and tracts

19
Q

What are some examples of drugs that are modulators of brain state?

A
  1. Fluoroooxtine

2. Prozac

20
Q

What can Fluoroxotin do?

A

Open periods of plasticity in the adult brain

- Enhance the effects of the training