CNS Lupus Flashcards
What is history of Lupus divided into?
- Classical
- Neoclassical
- Modern
What is Lupus described as?
Erosive facial lesions that were reminiscent of a wolf’s bite
What is the shape of Lupus?
Discoid lupus
What is Systemic Lupus Erythematosus?
A clinical syndrome, cause known, characterised by inflammation and multisystem involvement
Mainly a disease of women aged 15-50 (reproductive ears)
What is systemic Lupus Erythematosus a member of and give examples?
A member of the family of autoimmune rheumatic diseases:
- Rheumatoid’s syndrome
- Sherbone’s syndrome
- Polymyositis
- They coexist
What do 5% of Lupus patients have?
Erosive kind of arthritis
called Rufus
What do 15% of Lupus patients have?
Sherborne syndrome which cause profound dryness of the eyes and dryness of the mouth
What do 4% of Lupus patients have?
Muscle disease or myelitis
Where is Systemic Lupus Erythematosus common among?
Black (and probably Chinese) women than Caucasian women
What is matched by serological diversity?
Clinical diversity of Systemic Lupus Erythematosus
Why should SLE patients seen regularly?
This disease can affect any organ or system
What is the active and inactive disease of Lupus disease?
- Active disease: see every 1-3 months
2. Inactive disease: see 6-12 months
What is an example of drug that should be monitored carefully and what is it retreated by?
Hydroxychloroquine [treatment of malaria]
Retreated with non-steroidal, anti-inflammatory drugs
What does the drug Hydroxtchloroquine have?
Profound effect intracellularly
Affects the cellular PH
What is given to every Lupus patients?
Hydroxychloroquine
What is the consequence of taking too much of Hydroxychloroquine?
Take eye test as it causes balls-eye appearance at the back of ey e
What is given to treat more aggressive forms of Lupus?
Immunosuppressive drug
Steroids
How should Immunosuppressive drugs be monitored closely?
- Check their blood count
2. Their kidney and liver test
What is the number one test to do for the diagnosis of Lupus?
Anti-nuclear, antibody test (98%)
What does the nucleus house?
Nearly 2-3000 antigens
What is Ro/Lo?
- Combination of RNA and proteins
- Associated with photosensitivity
- Factor of 50
What can the antibodies of Ro/L0 do?
Cross the placenta and bind to the conducting tissue of heart
Heart beats in a disordered function [ heart block]
Heart block treated with a pacemaker
What are the 2 problems that Antiphospholipids are associated with?
- Clotting - Deep veins of the legs
2. Increasing Miscarriage
What is Increase in dsDNA associated with?
Renal disease
What are the co-morbidities for Lupus?
- Atherosclerosis
- Osteoporosis/ avascular necrosis
- Infection
- Cancer
What is strongly linked to the process of steroids?
Osteoporosis/avascular necrosis
What is Infection linked to?
Steroids and immunosuppressive drugs
What is decreased in Lupus patients?
Breast cancer
Endometrial cancer
Ovarian cancer
What is found in a 1/4 of the Lupus patients?
Hair loss
What are some examples of clinical characteristic in Lupus Clinic?
- Rash - 61%
- Photosensitivity - 35%
- Alopecia - 23%
- Oral ulcers - 26%
- Arthritis - 92%
- Serositis - 39%
- Renal - 30%
- CNS - 20%