stroke drugs Flashcards by Ellie Fox | Brainscape

Q

what is a transient ischaemic attack?

A

mini stroke

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Q

what is a ischaemic stroke?

A

blood clot

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Q

what is a haemorrhagic stroke?

A

bleed on the brain

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Q

what is the role of plasmin?

A

degrades fibrin in the clot

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Q

what activates plasmin?

A

rTPA’s, altepase

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Q

what is the action of warfarin?

A

inhibits Vit k reductase to thin the blood

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Q

what is the role of heparin?

A

activates antithrombin III

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Q

name 4 antiplatelet drugs?

A

abciximab, clopidogrel, aspirin, dyridamole

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Q

what is the action of dyridamole?

A

prevents thromboxane formation

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Q

what is the role of abciximab?

A

prevents GPIIa/IIb receptor interaction

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Q

what is the role of clopidogrel?

A

prevents GPIIa/IIb receptor interaction

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Q

what is the role of aspirin?

A

inhibits COX1 preventing thromboxane formation

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Q

name an example of a nitrovasodilator?

A

glyceryl trinitrate

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Q

is glyceryl trinitrate rapidly broken down by the liver?

A

yes

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Q

what is the action of glyceryl trinitrate?

A

produces nitric oxide that decreases cGMP= vasodilation

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Q

what are the side effects of glyceryl trinitrate?

A

throbbing headache due to cerebral vasodilation

Q

what are the roles of statins?

A

HMG-COA reductase inhibitors

Q

what are the side effects of statins?

A

GI upset, abnormal liver test, muscle problems