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pharmacology applied > arthritis > Flashcards

arthritis Flashcards

1
Q

what 3 processes cause the degradation in cartilage?

A

increase in metaloproteineases, IL-1B collagen synthesis of hyaline cartilage, cathespin B cleaves aggregan

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2
Q

what is the role of COX2?

A

protects GI mucousa, control of renal blood flow, initiation of labour

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3
Q

what are the roles of histamine and bradykinin?

A

increase permeability of venules, increased sensititivity of c fibres

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4
Q

name 5 examples of NSAIDS?

A

aspirin, ibuprofen, diclofenac, meloxicam, indomethacin

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5
Q

what is the role of aspirin?

A

inhibits NFKb expression

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6
Q

what is the role of ibuprofen and diclofenac?

A

decreases IL6 and TNFa in synovial fluid

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7
Q

what is would show in the blood tests of someone who has rheumatoid?

A

FBC, RF, ACPA

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8
Q

what are the problems with NSAIDS?

A

risk of gastric ulcer, impaired coagulation, amgiodema, urticaria, rhinitis

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9
Q

name 5 glucocorticoids?

A

cortisone, hydrocortisone, prednisolone, dexamethasone

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10
Q

what are the roles of glucocorticoids?

A

decrease transcription of IL2, decrease circulating lymphocytes, inhibit phospholipase A2 decreasing arachidonic acid

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11
Q

what are the side effects of glucocorticoids?

A

bufalo hump, moon face, increase abdo fat, increased muscle wasting, hypertension, increased risk of infection

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12
Q

name 3 examples of COX 2 inhibitors?

A

celecoxib, etoricoxib, etodolac

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13
Q

what are the side effects associated with COX 2 inhibitors?

A

headache, dizziness, rashes, peripheral oedema

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14
Q

name 3 DMARDS

A

methotrexate, sulfasalazine, penicillamire

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15
Q

what is the action of methotrexate?

A

folic acid antagonist

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16
Q

what are the side effects associated with methotrexate?

A

blood discaryhosis, liver cirhosis

17
Q

what is the action of sulfasalazine?

A

scavenges free radicals produced by neutrophils?

18
Q

what are the side effects associated with sulfasalazine?

A

GI upset, headache, skin reactions, leukopenia

19
Q

name 4 biologic agents?

A

adalimumab, entercept, infliximab, certolizumab

20
Q

what are the actions of biologic agents?

A

inhibit TNF

21
Q

name an example of an anti malarial?

A

chloroquine

22
Q

what are the actions of chloroquine?

A

apoptosis in t lymphocytes

23
Q

what are the side effects of chloroquine?

A

N+V, dizziness, blurred vision

24
Q

name an example of 4 immunosuppressants?

A

ciclosporin, cyclophosphamide, leflunomide, azathioprine

25
Q

what are the side effects associated with immunosuppresant drugs?

A

nephrotoxicity, hepatoxicity, hypertension

pharmacology applied (7 decks)

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