Stroke Flashcards
What is a stroke?
Collection of rapidly developing symptoms that are indicative of focal (sometimes global) brain damage with a vascular origin
Is stroke a diagnosis?
No - it leads to a diagnosis i.e. the underlying cause of it
What are the 3 main things you must note in a stroke history?
Time of onset
Symptoms
Progression
Why is it important to note time, symptoms and progression?
Various conditions can mimic a stroke
Name some conditions that can mimic a stroke
Seizures (Todd’s paresis causes unilateral weakness)
Sepsis (in patients with cerebral scar tissue from previous stroke)
Metabolic/toxic disorders
Hypoglycaemia
Dementia
Delirium/confusion
Space occupying lesions e.g. brain tumours
What is the main screening tool for assessing the likelihood of a stroke?
ROSIER Score
<0 = less likely
>0 - 1 = more likely
What are the types of stroke?
Haemorrhagic
Subarachnoid haemorrhage
Infarct
Name causes of haemorrhagic stroke
Structural abnormalities Extreme hypertension (causes vascular damage increasing risk of bleeding) Amyloid angiopathy (deposition of amyloid protein makes vessels more friable and prone to bleed)
Name causes of subarachnoid haemorrhage stroke
Head injury
Ruptured aneurysm
Name causes of infarct stroke
Structural abnormalities AF causing cardioembolic stroke Atherosclerosis causing Atheroembolic stroke Thrombophilia Small vessel disease
Can you clinically differentiate between each stroke type?
No, only through imaging
What is the first line imaging for stroke?
CT Scan
UNLESS:
- Patient presents >1 week late
- Stroke is minor (MRI more sensitive)
- Stroke is posterior (increased bone presence causes interference on CT)
How does blood show on a CT?
Bright white, due to iron presence
What must be remembered regarding haemorrhage and CT?
Blood is reabsorbed within 3 weeks of haemorrhage leaving an empty space and scar tissue so may not always be obvious on CT
Conduct MRI if patient presents >1 week late
What must be remembered with infarcts and CT?
CT MAY BE CLEAR
For infarcts to show on a CT, necrosis and oedema must occur, which takes time. If CT is conducted prior to this stage, it will be clear.
What imaging modality is good for infarct stroke?
MRI
Look for unilateral areas of corresponding black and white (ischaemic tissue impairs iron and water flow, resulting in these black and white areas)
List symptoms of stroke
Facial weakness and droopiness
Arm weakness
Slurred speech
What is the name given to salvageable brain tissue?
Penumbra
Stroke is a dynamic process, meaning brain is initially salvageable
What exam must always be done in ALL stroke patients?
Neurological exam
How is haemorrhagic stroke managed?
Control BP
- If patient presents in <6 hours and BP >150mmHg, give IV GTN
- If >6 hours, give Amlodipine
Reverse anticoagulants if patient is on any
How is infarct stroke managed?
Thrombolysis/Thrombectomy Swallowing Assessment Hydration and Nutrition Antiplatelets Stroke unit care DVT prophylaxis
What antiplatelets are given in stroke?
300mg Aspirin OR Aspirin with Clopidogrel (better in minor strokes or TIA)
What is thrombolysis?
Giving IV TPA to break down clots
What must be remembered about thrombolysis?
Cut off is 4.5 hours
May not work on large or proximal clots
Age does not matter
Bleeding is a side effect (check for previous stroke, hypertension and diabetes)
What is endovascular therapy?
Putting a wire through the clot and opening a stent around it to pull it out.
Done for large or proximal clots
What are consequences of stroke?
Aspiration pneumonia due to loss of coordination of swallowing muscles
DVT due to immobility (intermittent compressions stockings for prophylaxis)
What is a TIA?
Mini stroke and first aspect of the stroke spectrum which acts as a warning sign for future, more serious strokes
Are TIAs benign?
NO
Sign of an underlying vascular issue that needs to be managed
What are investigations for a TIA?
History
Blood tests
Carotid imaging for stenosis in the carotid arch, vessels and cerebral vessels
ECG
What screening tool is used to assess the likelihood of TIA and recurrent TIAs?
ABCD2
Checks age, BP, clinical features and diabetes
How is a TIA managed?
Immediate therapy starting from the GP office
Statin to reduce risk
300mg Aspirin or Aspirin with Clopidogrel
Carotid Endarterectomy for carotid stenosis